Hollmann, Frank - Delft University of Technology

研究领域

Our research interest focus around the application of oxidoreductases for organic synthesis. These enzymes have a lot to offer for the organic chemist in terms of selectivity and efficiency. In particular, we are interested in biocatalytic oxyfunctionalization reactions using monooxygenases and peroxygenases as well as reduction reactions using alcohol dehydrogenases and ene reductases. Specific research projects center around Simplified regeneration schemes: Direct, nicotinamide cofactor-independent reaction not only represent highly simplified reaction schemes but also offer some possibilities for biorthogonal and more selective reactions. More efficient use of electron donors: We aim at efficiently utilizing the stoichiometric reductant. For example, methanol is an attractive reductant if fully oxidized to CO2 and if all reducing equivalents are productively used to promote the biocatalytic reaction of interest. Eventually, we aim at using water as electron donor. Photobiocatalytic reactions: Illumination can significantly accelerate biochemical reactions such a flavin-dependent reactions. Furthermore, visible light can introduce thermodynamic driving force to make seemingly impossible reactions feasible (e.g. the catalytic oxidation of water). Biocatalytic redox chemistry in non-aqueous reaction media: Water may not always be the solvent of choice, especially if hydrophobic reagents are involved. We aim at developing reaction schemes that enable the efficient conversion of preparatively relevant reagent concentrations. (Chemo)enzymatic cascades: The combination of enzymes and ‘classical chemical’ catalysts represents an interesting concept combining the strengths of both worlds. Especially if combined in one-pot reactions, such cascades may be more than the sum of its parts. Environmentally acceptable chemistry: (Bio)catalysis is not environmentally benign or green per se. In all our efforts we try to keep a quantitative view on their environmental impact. For this, we particularly like to use Sheldon’s E-factor and further extensions of it.

近期论文

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A Minimized Chemoenzymatic Cascade for Bacterial Luciferase in Bioreporter Applications Phonbuppha, J., Tinikul, R., Wongnate, T., Intasian, P., Hollmann, F., Paul, C. E. & Chaiyen, P., 2020, In : ChemBioChem. 21, 14, p. 2073-2079 7 p. Biocatalytic axidation of alcohols Puetz, H., Puchľová, E., Vranková, K. & Hollmann, F., 2020, In : Catalysts. 10, 9, p. 1-30 952. Biocatalytic Reduction Reactions from a Chemist's Perspective Hollmann, F., Opperman, D. J. & Paul, C. E., 2020, In : Angewandte Chemie - International Edition. 59, p. 2-24 Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale Höfler, G. T., But, A., Younes, S. H. H., Wever, R., Paul, C. E., Arends, I. W. C. E. & Hollmann, F., 2020, In : ACS Sustainable Chemistry and Engineering. 8, 7, p. 2602-2607 Chemoenzymatic Halocyclization of γ,δ-Unsaturated Carboxylic Acids and Alcohols Younes, S. H. H., Tieves, F., Lan, D., Wang, Y., Süss, P., Brundiek, H., Wever, R. & Hollmann, F., 2020. 1 p. Enantioselective Sulfoxidation of Thioanisole by Cascading a Choline Oxidase and a Peroxygenase in the Presence of Natural Deep Eutectic Solvents Li, Y., Ma, Y., Li, P., Zhang, X., Ribitsch, D., Alcalde, M., Hollmann, F. & Wang, Y., 2020, In : ChemPlusChem. 85, 1, p. 254-257 Enzymatic Oxidation of Butane to 2-Butanol in a Bubble Column Perz, F., Bormann, S., Ulber, R., Alcalde, M., Bubenheim, P., Hollmann, F., Holtmann, D. & Liese, A., 2020, In : ChemCatChem. 12, 14, p. 3666-3669 4 p. Erratum: Correction: H2 as a fuel for flavin- and H2O2-dependent biocatalytic reactions (Chemical communications (Cambridge, England) (2020)) Al-Shameri, A., Willot, S. J. P., Paul, C. E., Hollmann, F. & Lauterbach, L., 2020, In : Chemical communications (Cambridge, England). 56, 66, p. 9570-9570 1 p. Evolved Peroxygenase-Aryl Alcohol Oxidase Fusions for Self-Sufficient Oxyfunctionalization Reactions Gomez De Santos, P., Lazaro, S., Viña-Gonzalez, J., Hoang, M. D., Sánchez-Moreno, I., Glieder, A., Hollmann, F. & Alcalde, M., 2020, In : ACS Catalysis. p. 13524-13534 11 p. Flavoenzyme-mediated Regioselective Aromatic Hydroxylation with Coenzyme Biomimetics Guarneri, A., Westphal, A. H., Leertouwer, J., Lunsonga, J., Franssen, M. C. R., Opperman, D. J., Hollmann, F., van Berkel, W. J. H. & Paul, C. E., 2020, In : ChemCatChem. 12, 5, p. 1368-1375 FOx News: Towards Methanol-driven Biocatalytic Oxyfunctionalisation Reactions Willot, S. J. P., Hoang, M. D., Paul, C. E., Alcalde, M., Arends, I. W. C. E., Bommarius, A. S., Bommarius, B. & Hollmann, F., 2020, In : ChemCatChem. 12, 10, p. 2713-2716 5 p. H2as a fuel for flavin- And H2O2-dependent biocatalytic reactions Al-Shameri, A., Willot, S. J. P., Paul, C. E., Hollmann, F. & Lauterbach, L., 2020, In : Chemical Communications. 56, 67, p. 9667-9670 Microscale Atmospheric Pressure Plasma Jet as a Source for Plasma-Driven Biocatalysis Yayci, A., Dirks, T., Kogelheide, F., Alcalde, M., Hollmann, F., Awakowicz, P. & Bandow, J. E., 2020, In : ChemCatChem. 12, 6 p. Natural deep eutectic solvents as performance additives for biocatalysis Erol, Ö. & Hollmann, F., 2020, (Accepted/In press) Advances in Botanical Research. Academic Press, (Advances in Botanical Research). Photobiocatalytic synthesis of chiral secondary fatty alcohols from renewable unsaturated fatty acids Zhang, W., Lee, J. H., Younes, S. H. H., Tonin, F., Hagedoorn, P. L., Pichler, H., Baeg, Y., Park, J-B., Hollmann, F. & Kourist, R., 2020, In : Nature Communications. 11, 1, 8 p., 2258. Photochemical regeneration of flavoenzymes – An Old Yellow Enzyme case-study Rauch, M. C. R., Huijbers, M. M. E., Pabst, M., Paul, C. E., Pešić, M., Arends, I. W. C. E. & Hollmann, F., 2020, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1868, 1, 140303. Photoenzymatic Production of Next Generation Biofuels from Natural Triglycerides Combining a Hydrolase and a Photodecarboxylase Ma, Y., Zhang, X., Zhang, W., Li, P., Li, Y., Hollmann, F. & Wang, Y., 2020, In : ChemPhotoChem. 4, 1, p. 39-44 Piezobiocatalysis: Ultrasound-Driven Enzymatic Oxyfunctionalization of C-H Bonds Yoon, J., Kim, J., Tieves, F., Zhang, W., Alcalde, M., Hollmann, F. & Park, C. B., 2020, In : ACS Catalysis. 10, 9, p. 5236-5242 Plasma-Driven in Situ Production of Hydrogen Peroxide for Biocatalysis Yayci, A., Baraibar, Á. G., Krewing, M., Fueyo, E. F., Hollmann, F., Alcalde, M., Kourist, R. & Bandow, J. E., 2020, In : ChemSusChem. 13, 8, p. 2072-2079 8 p. Production of fatty alcohols from non-edible oils by enzymatic cascade reactions Ma, Y., Zhang, X., Li, Y., Li, P., Hollmann, F. & Wang, Y., 2020, In : Sustainable Energy & Fuels. 4, 8, p. 4232-4237