个人简介

Roland Riek has been Full Professor of Physical Chemistry at ETH Zurich since May 2007. His group conducts research in the field of Biological NMR. Roland Riek was born in Bern in 1969. He studied Physics at ETH Zurich. After earning his diploma, he remained at ETH to do his PhD with Prof. Kurt Wüthrich at the Institute for Molecular Biology and Biophysics. He finished his PhD thesis about the NMR structure of the Mouse Prion Protein in 1998. After a few years as postdoc at the Institute for Molecular Biology and Biophysics at ETH, he joined the structural biology laboratory of the Salk Institute for Biological Studies in La Jolla, California, first, in 2001, as assistant professor, then in 2006 as associate professor, and director of the NMR facility.

研究领域

Biological NMR Spectroscopy

Research interests include the study of 3D structures of membrane proteins and misfolded protein aggregates associated with illnesses as well as the study of the dynamics of proteins and their interactions with other proteins.

近期论文

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Bibow, S., Carneiro, M., Sabo, T.M., Schwiegk, C., Becker, S., Riek, R., Lee, D. (2014) Measuring membrane protein bond orientations in nanodiscs via residual dipolar couplings. Protein Sci. 23, 851—856. Campioni, S., Carret, G., Jordens, S., Nicoud, L., Mezzenga, R.,; Riek, R. (2014) The Presence of an Air-Water Interface Affects Formation and Elongation of A-Synuclein Fibrils. J. Am. Chem. Soc. 136, 2866−2875. Daskalov, A.Y., Gantner, M., Wälti, M., Schmidlin, T., Chi, C., Wasmer, C., Schütz, A., Ceschin, J., Clavé, C., Cescau, S., Meier, B., Riek, R., Saupe, S. (2014) Contribution of Specific Residues of the beta-Solenoid Fold to HET-s Prion Function, Amyloid Structure and Stability. PLOS Pathogens 10, e1004158 Eichmann, C., Tzitzilonis, C., Bordignon, E., Maslennikov, I., Choe, S., Riek, R. (2014) Solution NMR Structure and Functional Analysis of the Integral Membrane Protein YgaP from Escherichia coli. J BIOL CHEM 289, 23482–23503. Jappelli, R., Perrin, M.H., Lewis, K.A., Vaughan, J.M., Tzitzilonis, C., Rivier, J.E., Vale, W.W. Riek, R. (2014) Expression and Functional Characterization of Membrane-Integrated Mammalian Corticotropin Releasing Factor Receptors 1 and 2 in Escherichia coli. PLOS ONE 9, e84013. Nespovitaya, N., Barylyuk, K., Eichmann, C., Zenobi, R., Riek, R. (2014) The production of recombinant 15N, 13C-labelled somatostatin 14 for NMR spectroscopy. Protein Expres Purif. 99, 78–86. artcle; Olsson, S., Vögeli, B., Cavalli, A., Boomsma, W., Ferkinghoff-Borg, J., Lindorff-Larsen, K., Hamelryck, T. (2014) Probabilistic Determination of Native State Ensembles of Proteins. J. Chem. Theory Comput. 2014, 10, 3484−3491. Riek, Roland. (2014) A Derivation of a Microscopic Entropy and Time Irreversibility From the Discreteness of Time. Entropy 16, 3149-3172. Rockenstein, E., Nuber, S., Overk, C. R., Ubhi, K., Mante, M., Patrick, C., Adame, A., Trejo-Morales, M., Gerez, J., Picotti, P., Jensen, P. H., Campioni, S., Riek, R., Winkler, J., Gage, F. H., Winner, B., Masliah, E. (2014) Accumulation of oligomer-prone alpha-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain 137, 1496-1513. Sgourakis, N.G., Natarajan, K., Ying, J., Vögeli, B.- Boyd, L.F., Margulies, D.H., Bax, A. (2014) The Structure of Mouse Cytomegalovirus m04 Protein Obtained from Sparse NMR Data Reveals a Conserved Fold of the m02-m06 Viral Immune Modulator Family. Structure 22, 1263-1273. Vilar, M., Sung, T., Chen, Z., Garcia-Carpio, I., Fernandez, E.M., Xu, J., Riek, R., Lee, K. (2014) Heterodimerization of p45-p75 Modulates p75 Signaling. Structural Basis and Mechanism of Action. PLOS Biol. 12, 45-75. Villinger, S., Giller, K., Bayrhuber, M., Lange, A., Griesinger, C., Becker, S., Zweckstetter, M. (2014) Nucleotide interactions of the human voltage-dependent anion channel. J Biol Chem. . 289, 13397–13406. Vögeli, Beat. (2014) The nuclear Overhauser effect from a quantitative perspective. Prog Nucl Mag Res Sp. 78, 1-46. Vögeli, B., Orts, J., Strotz, D., Chi, C., Minges, M., Wälti, M. A., Güntert, P., Riek, R. (2014) Towards a true protein movie. A perspective onthe potential impact of the ensemble-based structure determination using exact NOEs. J. Magn. Reson., 241, 53-59. Eichmann, C., Orts, J., Tzitzilonis, C., Vögeli, B., Smrt, S., Lorieau, J., Riek, R. (2014) Intermolecular Detergent-Membrane Protein NOEs for the Characterization of the Dynamics of Membrane Protein-Detergent Complexes. J Phys Chem B. 118, 14288-14301. Eichmann, C., Sobol, A., Pervushin, K., Riek, R. (2013) Polychromatic frequency encoding in indirect dimensions in NMR spectroscopy. Mol. Cel. Phys. 111, 765-770. Prots, I., Veber, V., Brey, S., Campioni, S., Buder, K., Riek, R., Böhm, K.J., Winner, B. (2013) {alpha}-Synuclein oligomers impair neuronal microtubule-kinesin interplay. J Biol Chem. 288, 21742-21754. Sonati, T., Reimann, R.R., Falsig, J., Baral, P.K., O’Connor, T., Hornemann, S., Yaganoglu, S., Li, B., Herrmann, U.S., Wieland, B., Swayampakula, M., Rahman, M.H., Das, D., Kav, N., Riek, R., Liberski, P.P., James, M.N., Aguzzi, A. (2013) The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature 501, 102-106. Sung, T.C., Chen, Z., Thuret, S., Vilar, M., Gage, F.H., Riek, R., Lee, K.F. (2013) P45 forms a complex with FADD an promotes neuronal cell survival following spinal cord injury. PLoS One. Epub 2013 June 23. Orts, J., Vögeli, B., Riek, R., Güntert, P., (2013) Stereospecific assignements in proteins using exact NOEs. J Biomol NMR, 57, 211-218. Vögeli, B., Güntert, P., Riek, R. (2013) Multiple-state Ensemble Structure Determination from eNOE Spectroscopy. Mol. Phys., 111, 437-454.