Diederich, François - Eidgenössische Technische Hochschule Zürich - Department of Chemistry and Applied Biosciences

个人简介

Professor Diederich (b. 1952) received his diploma in 1977 and his doctoral degree (Dr. rer. nat.) in 1979 from the University of Heidelberg. Following postdoctoral studies at the University of California at Los Angeles (UCLA) from 1979 to 1981, he was a research associate at the Max-Planck-Institute for medical research in Heidelberg. After his habilitation in 1985, he joined the faculty of the Department of Chemistry and Biochemistry at UCLA as an associate professor (1985-1989) and as a full professor (1989-1992). Since April 1992, he is a professor of organic chemistry at ETH Zurich. He received the Otto Hahn Medal of the Max- Planck-Society (1979), the Dreyfus Teacher-Scholar Award (1987), the ACS Arthur C. Cope Scholar Award (1992), the Otto-Bayer-Preis für Chemie (1993), the Janssen Prize for Creativity in Organic Synthesis (2000) and the Havinga Medal (2000), the Humboldt Research Prize (2005), the Burkhard-Helferich Prize (2005), the August-Wilhelm-von-Hofmann-Denkmünze (GDCh, 2006), and the ACS Ronald Breslow Award for Achievements in Biomimetic Chemistry (2007). He is a member of the Deutsche Akademie der Naturforscher Leopoldina, the American Academy of the Arts and Sciences, the Berlin-Brandenburgische Akademie der Wissenschaften (BBAW), and the Real Academia Española de Ciencias. Since 2012, he is a foreign associate of the US National Academy of Sciences

研究领域

Organic Materials/Supramolecular Chemistry

近期论文

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R. K. Castellano, V. Gramlich, F. Diederich, Chem. Eur. J. 2002, 8, 118-129. Rebek imides and their adenine complexes: Preferences for Hoogsteen binding in the solid state and in solution. E. A. Meyer, R. K. Castellano, F. Diederich, Angew. Chem. Int. Ed. 2003, 42, 1210-1250. Interactions with aromatic rings in chemical and biological recognition. J. A. Olsen, D. W. Banner, P. Seiler, U. O. Sander, A. D'Arcy, M. Stihle, K. Müller, F. Diederich, Angew. Chem. Int. Ed. 2003, 42, 2507-2511. A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: Evidence for C-F...C=O interactions. R. Faraoni, M. Blanzat, S. Kubicek, C. Braun, W. B. Schweizer, V. Gramlich, F. Diederich, Org. Biomol. Chem. 2004, 2, 1962-1964. New Rebek imide-type receptors for adenine featuring acetylene-linked pi-stacking platforms. R. Faraoni, R. K. Castellano, V. Gramlich, F. Diederich, Chem. Commun. 2004, 370-371. H-bonded complexes of adenine with Rebek imide receptors are stabilised by cation-pi interactions and destabilised by stacking with perfluoroaromatics. F. Hof, D. M. Scofield, W. B. Schweizer, F. Diederich, Angew. Chem. Int. Ed. 2004, 43, 5056-5059. A weak attractive interaction between organic fluorine and an amide group. R. Paulini, K. Müller, F. Diederich, Angew. Chem. Int. Ed. 2005, 44, 1788-1805. Orthogonal multipolar interactions in structural chemistry and biology. K. Schärer, M. Morgenthaler, R. Paulini, U. Obst-Sander, D. W. Banner, D. Schlatter, J. Benz, M. Stihle, F. Diederich, Angew. Chem. Int. Ed. 2005, 44, 4400-4404. Quantification of cation-pi interactions in protein-ligand complexes: Crystal-structure analysis of factor Xa bound to a quaternary ammonium ion ligand. E. Schweizer, A. Hoffmann-Röder, J. A. Olsen, P. Seiler, U. Obst-Sander, B. Wagner, M. Kansy, D. W. Banner, F. Diederich, Org. Biomol. Chem. 2006, 4, 2364-2375. Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors. E. Schweizer, A. Hoffmann-Röder, K. Schärer, J. Olsen, C. Fäh, P. Seiler, U. Obst-Sander, B. Wagner, M. Kansy, F. Diederich, ChemMedChem 2006, 1, 611-621. A Fluorine scan at the catalytic center of thrombin: C–F, C–OH, and C–OMe Bioisosterism and Fluorine Effects on pKa and log D Values. A. K. H. Hirsch, F. R. Fischer, F. Diederich, Angew. Chem. Int. Ed. 2007, 46, 338-352. Phosphate recognition in structural biology. M. Morgenthaler, E. Schweizer, A. Hoffmann-Röder, F. Benini, R. E. Martin, G. Jaeschke, B. Wagner, H. Fischer, S. Bendels, D. Zimmerli, J. Schneider, F. Diederich, M. Kansy, K. Müller, Chemmedchem 2007, 2, 1100-1115. Predicting properties and tuning physicochemical in lead optimization: Amine basicities. K. Müller, C. Fäh, F. Diederich, Science 2007, 317, 1881-1886. Fluorine in pharmaceuticals: Looking beyond intuition. F. R. Fischer, W. B. Schweizer, F. Diederich, Angew. Chem. Int. Ed. 2007, 46, 8270-8273. Molecular torsion balances: Evidence for favorable orthogonal dipolar interactions between organic fluorine and amide groups. Zürcher, M.; Gottschalk, T.; Meyer, S.; Bur, D.; Diederich, F. "Exploring the Flap Pocket of the Antimalarial Target Plasmepsin II: The "55% Rule", ChemMedChem 2008, 3, 237-240. Morgenthaler, M.; Aebi, J. D.; Grüninger, F.; Mona, D.; Wagner, B,; Kansy, M.; Diederich, F. "A Fluorine Scan of Non-Peptidic Inhibitors of Neprilysin: Fluorophobic and Fluorophilic Regions in an Enzyme Active Site", J. Fluorine Chem. 2008, 129, 852-865. Zürcher, M.; Diederich, F. "Structure-Based Drug Design: Exploring the Proper Filling of Apolar Pockets at Enzyme Active Sites", J. Org. Chem. 2008, 73, 4345-4361. Fischer, F. R.; Wood, P. A.; Allen, F. H.; Diederich, F. "Orthogonal Dipolar Interactions Between Amide Carbonyl Groups", Proc. Natl. Acad. Sci. U.S.A., 2008, 105, 17290-17294. Fischer, F. R.; Schweizer W. B.; Diederich, F. "Substituent Effects on the Aromatic Edge-to-Face Interaction", Chem. Commun. 2008, 4031-4033. Salonen, L. M.; Bucher, C.; Banner, D. W.; Haap, W.; Mary, J.-L.; Benz, J.; Kuster, O.; Seiler, P.; Schweizer, W. B.; Diederich, F. "Cation- π Interactions at the Active Site of Factor Xa: Dramatic Enhancement Upon Stepwise N-Alkylation of Ammonium Ions", Angew. Chem. 2009, 121, 825 –828; Angew. Chem. Int. Ed. 2009, 48, 811-814.