个人简介

Professor Altmann was born in 1957 in Hochheim/Main, Germany. He studied chemistry at the Johannes-Gutenberg University in Mainz, from where he graduated with a diploma in 1983. His subsequent Ph. D. work in the area of peptide chemistry was performed at the University of Basel from 1984-1986. Karl-Heinz Altman then spent two and a half years as a post-doctoral associate at Cornell University, Ithaca, NY, which was followed by a one year stay as a master assistant at the University of Lausanne. In Sept. 1990 Karl-Heinz Altmann joined Ciba-Geigy-s Central Research Laboratories in Basel, where he worked on the design and synthesis of modified nucleosides as potential building blocks for antisense therapeutics until 1996. In 1997 he moved to Oncology Research within Novartis Pharma AG, which had been formed through the merger between Sandoz and Ciba-Geigy. After four years as a project leader in Oncology Research Karl-Heinz Altmann was appointed the Novartis Senior Chemistry Expert in 2000. From Jan. 2003 until his move to the ETH, he was the acting Global Head of Chemistry of the Novartis Institutes for BioMedical Research. In 1998 Karl-Heinz Altmann received the "Novartis Leading Scientist Award", an important internal science award of Novartis Pharma AG.

研究领域

Pharmaceutical Biology

Prof. Altmann-s research interests are at the interface between chemistry and biology, with a particular focus on the chemical synthesis and the biological and pharmacological profiling of biologically active natural products and their synthetic and semi-synthetic analogs. This research on one hand aims at the understanding of the mechanism of action of such molecules and the elucidation of the structural requirements for biological activity. On the other hand, it tries to assess the therapeutic potential of such compounds with the ultimate goal to discover new therapeutics for clinical applications.

近期论文

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Synthesis and Antimicrobial Activity of 2,1'-Dihydropyridomycins Horlacher, O.P.; Hartkoorn, R. C.; Cole, S. T.; Altmann, K.-H. ACS Medicinal Chemistry Letters, Ahead of Print. Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents. Prota AE, Bargsten K, Zurwerra D, Field JJ, Díaz JF, Altmann KH, Steinmetz MO. Science. 2013 Jan 3. [Epub ahead of print] Total Synthesis of (-)-Zampanolide and Structure-Activity Relationship Studies on (-)-Dactylolide Derivatives Zurwerra, D.; Glaus, F.; Betschart, L.; Schuster, J.; Gertsch, J.; Ganci, W.; Altmann, K.-H. Chemistry, 2012, 18(52), 16868-16883. Towards a new Tuberculosis Drug: Pyridomycin - Nature's Isoniazid Hartkoorn, R. C.; Sala, C.; Neres, J.; Pojer, F.; Magnet, S.; Mukherjee, R.; Uplekar, S.; Boy-Roettger, S.; Altmann, K.-H.; Cole, S. T. EMBO Molecular Medicine (2012), 4(10), 1032-1042. Zampanolide, a Potent New Microtubule-Stabilizing Agent, Covalently Reacts with the Taxane Luminal Site in Tubulin α,β-Heterodimers and Microtubules Field, J. J.; Pera, B.; Calvo, E.; Canales, A.; Zurwerra, D.; Trigili, C.; Rodriguez-Salarichs, J.; Matesanz, R.; Kanakkanthara, A.; Wakefield St. J.; Singh A. J.; Jimenez-Barbero, J.; Northcote, P.; Miller, J. H.; Lopez, J. A.; Hamel, E.; Barasoain, I.; Altmann, K.-H.; Diaz, J.F. Chemistry & Biology (Oxford, United Kingdom) (2012), 19(6), 686-698. Probing the Bioactivity-Relevant Chemical Space of Robust Reactions and Common Molecular Building Blocks Hartenfeller, M.; Eberle, M.; Meier, P.; Nieto-Oberhuber, C.; Altmann, K.-H.; Schneider, G.; Jacoby, E.; Renner, S. Journal of Chemical Information and Modeling (2012), 52(5), 1167-1178. Immunosuppressiv Small Molecule Discovered by Structure-Based Virtual Screening for Inhibitors of Protein-Protein Interactions Geppert, T.; Bauer, S.; Hiss, J. A.; Conrad, E.; Reutlinger, M.; Schneider, P.; Weisel, M.; Pfeiffer, B.; Altmann, K.-H.; Waibler, Z.; Schneider, G. Angewandte Chemie, International Edition, 2012, 51(1), 258-261. A Ring-Closing Metathesis-Based Approach to the Synthesis of (+)-Tetrabenazine Johannes M.; Altmann K.-H. Organic Letters, 2012, 14(14), 3752-3755. Total Synthesis of the bacterial RNA polymerase inhibitor ripostatin B. Glaus F.; Altmann K.-H. Angewandte Chemie (International ed. in English), 2012, 51(14), 3405-9. A Collection of Robust Organic Synthesis Reactions for In Silico Molecule Design Hartenfeller, M.; Eberle, M.; Meier, P.; Nieto-Oberhuber, C.; Altmann, K.-H.; Schneider, G.; Jacoby, E.; Renner, S. Journal of Chemical Information and Modeling, 2011, 51(12), 3093-3098. Ginger Phenylpropanoids Inhibut IL-1β and Prostanoid Secretion and Disrupt Arachidonate-PHospholipid Remodelling by Targeting Phospholipases A2 Nievergelt, A.; Marazzi, J.; Schoop, R.; Altmann, K.-H.; Gertsch, J. Journal of Immunology, 2011, 187(8), 4140-4150. Mechanisms of Osteoclastogenesis Inhibition by a Novel Class of Biphenyl-Type Cannabinoid CB2 Receptor Inverse Agonists Schuehly, W.; Paredes, J. M. V.; Kleyer, J.; Huefner, A.; Anavi-Goffer, S.; Raduner, S.; Altmann, K.-H.; Gertsch, J. Chemistry & Biology, 2011, 18(8), 1053-1064. Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives. Altmann, K.-H., Gaugaz, F. Z., Schiess, R. Mol.Divers. 2011, 15, 383-399. Stereoselective Synthesis of 12,13-Cyclopropyl-Epothilone B and Side-Chain-Modified Variants. R. Schiess, R., Gertsch, J., Schweizer, W. B., Altmann. K.-H. Org. Lett., 2011, 13, 1436-1439. Kinase Inhibition by Deoxy Analogs of the Resorcylic Lactone L-783277. Liniger, M., Neuhaus, C., Hofmann, T., Fransioli-Ignazio, L., Jordi, M., Drueckes, P., Trappe, J., Fabbro, D., Altmann, K.-H. ACSMed. Chem. Lett., 2011, 2, 22-27. A ring-closing metathesis (RCM)-based approach to mycolactones A/B. Gersbach P.; Jantsch A.; Feyen F.; Scherr N.; Dangy J.-P.; Pluschke G.; Altmann K.-H. Chemistry, 2011, 17(46), 13017-31. The Binding Mode of Side Chain- and C3-Modified Epothilones to Tubulin. Erdelyi, M., Navarro-Vazquez, A., Pfeiffer, B., Kuzniewski, C. N., Felser, A., Widmer, T., Gertsch, J., Pera, B., Diaz, J. F., Altmann, K.-H., T. Carlomagno, T., ChemMedChem, 2010, 5, 911-920. Identification of serotonin 5-HT1A receptor partial agonists in ginger. Nievergelt, A., Huonker, P., Schoop, R., Altmann, K.-H. Bioorg. Med. Chem., 2010, 18, 3345-3351. Highly Potent Modulation of GABAA Receptors by Valerenic Acid Derivatives. Kopp, S., Baur, R., Sigel, E., Moehler, H., Altmann, K.-H. ChemMedChem, 2010, 5, 678-681. Synthesis of (-)-Dactylolide and 13-Desmethylene-(-)-dactylolide and Their Effects on Tubulin. Zurwerra, D., Gertsch, J., Altmann, K.-H. Org. Lett., 2010, 12, 2302-2305.