个人简介
叶海辉（1970.10-），男，籍贯浙江，2001年于厦门大学获博士学位，现任职集美大学教授、水产学科领军人才。长期研究甲壳动物生理及养殖技术，先后主持国家自然科学基金7项，主持和参加其他科研项目20余项，在Journal of Endocrinology、Molecular and Cellular Endocrinology、Biology of Reproduction、 Frontiers in Immunology等期刊发表学术论文150余篇（SCI收录80余篇），授权国家专利17项（发明专利12项）。
教育经历
1996-2001年，厦门大学海洋生物学，博士学位
1989-1993年，浙江师范大学生物学，学士学位
工作经历
2020年至今，集美大学水产学院，教授、博士生导师
2011-2020年，厦门大学海洋与地球学院，教授、博士生导师
2004-2011年，厦门大学海洋与环境学院，副教授、硕士生导师
2002-2004年，厦门大学生命科学学院，博士后
2001-2004年，厦门大学海洋学系，讲师
1993-1996年，浙江省洞头区第一中学，教师
研究成果
1. 对青蟹内分泌作用及信号通路开展了全面系统的研究，发现其卵巢内部存在多种自分泌/旁分泌因子，开辟了甲壳动物生殖自分泌/旁分泌研究新领域。
2. 对青蟹神经内分泌-免疫系统（NEI）开展探索研究，阐明了多种短神经肽对青蟹的免疫调节机制，为新型免疫调节剂的研制与应用奠定基础。
3. 建立和完善了青蟹大规模人工育苗、苗种标粗、工厂化养殖以及家系选育等技术，推动了青蟹养殖产业的发展。
4. 深入解析了条纹鞭腕虾（雌雄同体）的性别分化、性腺发育及生殖内分泌机制，为观赏虾繁殖研究提供关键技术路线。
近年科研项目
1. 拟穴青蟹咽侧体抑制素（AST）内分泌调节机制研究（国家自然科学基金项目, 2020-2023年, 主持）
2. 拟穴青蟹短神经肽F（sNPF）生殖调控作用及机制（国家自然科学基金项目, 2018-2021年, 主持）
3. 拟穴青蟹促性腺激素释放激素（GnRH）生殖旁分泌作用及信号通路分析（国家自然科学基金项目, 2015-2018年，主持）
4. RPCH对拟穴青蟹卵巢发育的调控机制及应用基础研究（国家自然科学基金项目, 2013-2016年, 主持）
5. 蟹类工业化养殖设施的研制（福建省科技计划项目，2017-2020年，主持）
6. 海洋蟹类卵巢促熟剂的研发及应用（厦门市海洋经济发展专项，2014-2017年，主持）
7. 拟穴青蟹产业化技术体系创新与推广（中央引导地方科技发展专项，2020-2023年，参加）
8. 陆基集约化养殖青蟹技术研究与推广（福建省星火计划项目，2019-2022年，参加）
9. 拟穴青蟹工厂化养殖关键技术与示范（广东省科技计划项目，2017-2019年，参加）
10. 拟穴青蟹高产、抗逆（病）良种选育（浙江省科学技术厅“十三五”农业新品种选育重大专项，2016-2020年，参加）
11. 红膏蟹工厂化培育技术示范与推广（福建省星火计划项目, 2016-2018年, 参加）
12. 拟穴青蟹卵巢滤泡细胞旁分泌作用研究（国家自然科学基金项目, 2015-2018年，参加）
获批专利
1. 叶海辉. 海洋蟹类陆基工厂化养殖装置（实用新型, 专利号：201721859717.7 授权公告日：2018年06月28日）
2. 叶海辉. 一种青蟹陆基工厂化养殖装置. （实用新型, 专利号: 2015 2 0079291.8, 授权公告日：2015年07月01日）
3. 叶海辉, 黄辉洋, 王桂忠, 林琼武, 李少菁. 一种抑制青蟹自相残杀的方法 （发明, 专利号： 2012 1 0294674.8, 授权公告日：2014年06月11日）
4. 叶海辉, 王桂忠, 林琼武, 李少菁. 青蟹苗种分级培育及移苗方法 （发明, 专利号： 2009 1 0112400.0, 授权公告日：2013年03月27日）
5. 巩杰，杨六龙，刘学良，叶海辉. 池底吸污器（实用新型, 专利号：2012 2 0523917.6, 授权公告日：2013年03月20日）
6. 叶海辉, 王桂忠, 林琼武, 李少菁. 青蟹的阶段式群体选育方法 （发明, 专利号：ZL 2009 1 0112399.1, 授权公告日：2013年03月20日 ）
7. 叶海辉, 王桂忠, 黄辉洋, 李少菁. 软壳青蟹人工培育方法（发明, 专利号：ZL 2010 1 0502821.7, 授权公告日：2013年03月20日 ）
8. 叶海辉, 黄辉洋, 王桂忠, 李少菁. 一种促进青蟹卵巢成熟和抱卵的方法（发明, 专利号： ZL 2010 1 0116047.6, 授权公告日：2012年09月26日）
9. 叶海辉, 王桂忠, 林琼武, 李少菁. 青蟹家系的建立和良种选育方法 （发明, 专利号：ZL 2009 1 0112401.5，授权公告日：2011年06月08日）
10. 林琼武, 王桂忠, 叶海辉, 李少菁, 艾春香, 陈学雷. 青蟹膏蟹秋冬季的培育方法（发明, 专利号：ZL 2008 1 0071367.7， 授权公告日：2010.11.10）
11. 叶海辉, 王桂忠, 林琼武, 李少菁. 青蟹网箱育膏方法（发明, 专利号：ZL 2007 1 0009874.3, 授权公告日：2010年10月13日）
12. 叶海辉, 王桂忠, 林琼武, 李少菁. 青蟹笼养育肥方法（发明, 专利号：ZL 2007 1 0009873.9, 授权公告日：2010年10月08日）
13. 叶海辉, 王桂忠, 林琼武, 李少菁, 陈学雷, 艾春香. 青蟹仔蟹培育池及培育方法（发明, 专利号： ZL 2007 1 000 8829.6, 授权公告日：2010年2月24日）
14. 叶海辉, 林琼武. 一种促进日本对虾卵巢成熟和产卵的方法（发明, 专利号：ZL 2006 1 0005328.8?? 授权公告日：2008.07.09）
15. 叶海辉, 王桂忠, 林琼武, 李少菁. 海洋蟹类蟹苗运输箱（实用新型, 专利号：ZL 2005 2 0007918.5）
16. 叶海辉, 陈学雷, 林琼武, 王桂忠, 李少菁, 艾春香. 蟹苗变态网箱（实用新型, 专利号：ZL 2006 2 0002690.5）
17. 林琼武, 王桂忠, 李少菁, 陈学雷, 叶海辉. 青蟹蟹苗中间培育的养殖装置（实用新型, ZL 2008 2 0101398.8）
近期论文
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1. Lu B, Jiang QL, Liu A, Huang HY*, Ye HH*. Stimulatory roles of epidermal growth factor receptor (EGFR) in ovarian development of mud crab Scylla paramamosain. General and Comparative Endocrinology, 2020, 299: 113616.
2. Jiang QL, Lu B, Wang GZ, Ye HH*. Transcriptional inhibition of SpIAG by crustacean female sex hormone in the mud crab, Scylla paramamosain. International Journal of Molecular Sciences, 2020, 21:5300.
3. Xu ZN, Liu A, Li SK, Wang GZ, Ye HH*. Hepatopancreas immune response during molt cycle in the mud crab, Scylla paramamosain. Scientific Reports, 2020, 10: 13102.
4. Shi WY, Liu F, Liu A, Huang HY, Lin Q, Zeng CS*, Ye HH*. Roles of gonad-inhibiting hormone in the protandric simultaneous hermaphrodite peppermint shrimp. Biology of Reproduction, 2020,1-11; doi: 10.1093/biolre/ioaa111
5. Xu ZN, Wei YJ, Guo SL, Lin DD, Ye HH*. B-type allatostatin modulates immune response in hepatopancreas of mud crab Scylla paramamosain. Developmental and Comparative Immunology, 2020, 110: 103725.
6. Bao CC, Liu F, Yang YN, Lin Q, Ye HH*. Identification of peptides and their GPCRs in the peppermint shrimp Lysmata vittata, a protandric simultaneous hermaphrodite species. Frontiers in Endocrinology-Experimental Endocrinology, 2020, 11: 226.
7. Wei YJ, Lin DD, Xu ZN, Gao XM, Zeng CS, Ye HH*. A possible role of crustacean cardioactive peptide in regulating immune response in hepatopancreas of mud crab. Frontiers in Immunology-Comparative Immunology, 2020, 11:711.
8. Xu ZN, Wei YJ, Guo SL, Lin DD, Ye HH*. Short neuropeptide F (sNPF) enhances the immune response in the hepatopancreas of mud crab (Scylla paramamosain). Fish and Shellfish Immunology, 2020, 101:244-251.
9. Lin DD, Wei YJ, Ye HH*. Role of oxytocin/vasopressin-like peptide and its receptor in vitellogenesis of mud crab. International Journal of Molecular Sciences, 2020, 21: 2297.
10. Jiang QL, Lin DD, Huang YH, Wang GZ, Ye HH*. DNA methylation inhibits the expression of CFSH in mud crab. Frontiers in Endocrinology-Experimental Endocrinology, 2020, 11:163.
11. Jiang QL, Lu B, Lin DD, Chen XL, Huang HY*, Ye HH*. Role of crustacean female sex hormone (CFSH) in sex differentiation in early juvenile mud crabs, Scylla paramamosain. General and Comparative Endocrinology, 2020, 289:113383.
12. Zhang XX, Zhang M, Zheng HP, Ye HH, Zhang XS, Li SK. Source of hemolymph microbiota and their roles in the immune system of mud crab, Developmental and Comparative Immunology, 2020, 102: 103470.
13. Liu J, Liu A, Liu F, Huang HY*, Ye HH*. Role of neuroparsin 1 in vitellogenesis in the mud crab, Scylla paramamosain. General and Comparative Endocrinology, 2020, 285:113248.
14. Liu A, Liu F, Shi WY, Huang HY*, Wang GZ, Ye HH*. C-type allatostatin and its putative receptor from the mud crab serve an inhibitory role in ovarian development. Journal of Experimental Biology, 2019, 222: jeb207985.
15. Gong J, Shi WY, Zhang M, Wang TF, Yu K, Ye HH*. Characterization and expression analysis of E75 during ovarian development and juvenile growth of the mud crab, Scylla paramamosain Estampador,1950 (Brachyura: Portunidae), Crustaceana, 2019, 92(9):1063-1079.
16. Huang HY, Huang CC, Guo LM, Zeng CS*, Ye HH*. Profiles of calreticulin and Ca2+ concentration under low temperature and salinity stress in the mud crab, Scylla paramamosain. PLoS ONE, 2019, 14(7): e0220405.
17. Long XW, Wu XG, Zhu SC, Ye HH, Cheng YX, Zeng CS. Salinity can change the lipid composition of adult Chinese mitten crab after long-term salinity adaptation. PLoS ONE, 2019, 14(7): e0219260.
18. Yang YN, Lin DD, Bao CC, Huang HY, Ye HH*. Serotonergic mechanisms of oocyte germinal vesicle breakdown in the mud crab, Scylla paramamosain. Frontiers in Physiology-Invertebrate Endocrinology, 2019, 10:797.
19. Chen DM, Liu F, Zhu ZH, Lin Q*, Zeng CS, Ye HH*. Ontogenetic development of gonads and external sexual characters of the protandric simultaneous hermaphrodite peppermint shrimp, Lysmata vittata (Caridea: Hippolytidae). PLoS ONE, 2019, 14(4): e0215406.
20. Liu A, Liu J, Chen XL, Lu B, Zeng CS*, Ye HH*. A novel crustacean hyperglycemic hormone (CHH) from the mud crab Scylla paramamosain regulating carbohydrate metabolism. Comparative Biochemistry and Physiology-Part A: Molecular & Integrative Physiology, 2019, 231: 49-55.
21. Bao CC, Yang YN, Zeng CS, Huang HY, Ye HH*. Identifying neuropeptide GPCRs in the mud crab, Scylla paramamosain, by combinatorial bioinformatics analyses, General and Comparative Endocrinology, 2018, 269: 122-130.
22. Bao CC, Ye HH*, Yang YN, Huang HY. Voltage-dependent calcium channels in the neurosecretory cells of cerebral ganglia of the mud crab, Scylla paramamosain. NeuroReport, 2018, 29(13): 1068-1074.
23. Bao CC, Yang YN, Huang HY, Ye HH*. Inhibitory role of the mud crab short neuropeptide F in vitellogenesis and oocyte maturation via autocrine/paracrine signaling. Frontiers in Endocrinology-Experimental Endocrinology, 2018, 9: 390.
24. Liu A, Liu J, Liu F, Huang YY, Wang GZ, Ye HH*. Crustacean female sex hormone from the mud crab Scylla paramamosain is highly expressed in prepubertal males and inhibits the development of androgenic gland. Frontiers in Physiology-Aquatic Physiology, 2018, 9: 924.
25. Yang YN, Su L, Jiang QL, Huang HY*, Ye HH*. Does the bone morphogenetic protein 7 (BMP7) inhibit oocyte maturation by autocrine/paracrine in mud crab? General and Comparative Endocrinology, 2018,266:119-125.
26. Long XW, Wu XG, Zhao L, Ye HH, Cheng YX, Zeng CS. Physiological responses and ovarian development of female Chinese mitten crab Eriocheir sinensis subjected to different salinity conditions. Frontiers in Physiology-Aquatic Physiology, 2018, 8: 1072.
27. Jiang QL, Bao CC, Yang YN, Liu A, Liu F, Huang HY, Ye HH*. Transcriptome profiling of claw muscle of the mud crab (Scylla paramamosain) at different fattening stages. PLoS ONE, 2017, 12(11): e0188067.
28. Huang XS, Feng BY, Huang HY, Ye HH*. In vitro stimulation of vitellogenin expression by insulin in the mud crab, Scylla paramamosain, mediated through PI3K/Akt/TOR pathway. General and Comparative Endocrinology, 2017, 250:175-180.
29. Long XW, Wu XG, Zhao L, Ye HH, Cheng YX, Zeng CS. Effects of salinity on gonadal development, osmoregulation and metabolism of adult male Chinese mitten crab, Eriocheir sinensis. PLoS ONE, 2017, 12(6): e0179036.
30. Huang XS, Ye HH, Chung JS*. The presence of an insulin-like androgenic gland factor (IAG) and insulin-like peptide binding protein (ILPBP) in the ovary of the blue crab, Callinectes sapidus and their roles in ovarian development. General and Comparative Endocrinology, 2017, 249: 64-70.
31. Huang CC, Yu K, Huang HY, Ye HH*. Adenosine monophosphate-activated protein kinase (AMPK) from the mud crab, Scylla paramamosain: cDNA cloning and profiles under cold stress. Journal of Genetics, 2016, 95(4): 923-932.
32. Huang XS, Bae SH, Bachvaroff TR. Schott EJ, Ye HH*, Chung JS*. Does a blue crab putative insulin-like peptide binding protein (ILPBP) play a role in a virus infection? Fish and Shellfish Immunology, 2016, 58:340-348.
33. Yang YN, Zheng BQ, Bao CC, Huang HY, Ye HH*. Vitellogenin 2: spermatozoon specificity and immunoprotection in mud crabs. Reproduction, 2016, 152: 235-243.
34. Su L, Yang YN, Huang HY, Ye HH*. A bone morphogenetic protein ligand and receptors in the mud crab, Scylla paramamonsain: a potential role in the ovarian development. Molecular and Cellular Endocrinology, 2016, 434:99-107.
35. Gong J, Huang CC, Shu L, Huang HY, Ye HH*, Zeng CS*, Li SJ. The retinoid X receptor (RXR) from mud crab: new insight into its role in the ovarian development and related signaling pathway. Scientific Reports, 2016, 6:23654.
36. Fu CR, Huang XS, Gong J, Chen XL, Huang HY*, Ye HH*. Crustacean hyperglycemic hormone gene from the mud crab, Scylla paramamosain: cloning, distribution and expression profiles during the molting cycle and ovarian development. Aquaculture Research, 2016, 47(7): 2183-2194.
37. Zeng H, Bao CC, Huang HY, Ye HH*, Li SJ. The mechanism of regulation of ovarian maturation by red pigment concentrating hormone in the mud crab Scylla paramamosain. Animal Reproduction Science, 2016, 164: 152-161.
38. Bao CC, Yang YN, Huang YH, Ye HH*. Neuropeptides in the cerebral ganglia of the mud crab, Scylla paramamosain: transcriptomic analysis and expression profiles during vitellogenesis. Scientific Reports, 2015, 5:17055.
39. Huang XS, Ye HH*, Feng BY, Huang HY. Insights into insulin-like peptide system in invertebrates from studies on IGF binding domain-containing proteins in the mud crab, Scylla paramamosain. Molecular and Cellular Endocrinology, 2015, 416:36-45.
40. Yu K, Gong J, Huang CC, Huang HY, Ye HH*, Wang GZ, Zeng CS*. Characterization of CCTα and evaluating its expression in the mud crab Scylla paramamosain when challenged by low temperatures alone and in combination with high and low salinity. Cell Stress & Chaperones, 2015, 20(5): 853-864.
41. Huang XS, Ye HH*, Huang HY, Liu A, Feng BY. Implication for the regulation of catabolism drawn from the single insulin-like growth factor binding domain protein (SIBD) gene in the mud crab, Scylla paramamosain. General and Comparative Endocrinology, 2015, 216: 24-32.
42. Li WX, Huang HY*, Huang JR, Ye HH*. Evidence for cyclin A and cyclin B genes in the ovary of the horseshoe crab, Tachypleus tridentatus: molecular cloning and expression profiles. Marine and Freshwater Behaviour and Physiology, 2015, 48(3): 163-176.
43. Gong J, Ye HH*, Xie YJ, Yang YN, Huang HY, Li SJ, Zeng CS*. Ecdysone receptor in the mud crab Scylla paramamosain: a possible role in promoting ovarian development. Journal of Endocrinology, 2015, 224(3): 273-287.
44. Huang HY, Fu CR, Chen XL, Gong J, Huang XS, Ye HH*. Molt-inhibiting hormone (MIH) gene from the green mud crab Scylla paramamosain and its expression during the molting and ovarian cycle. Aquaculture Research, 2015, 46(11):2665-2675.
45. Gong J, Yu K, Shu L, Ye HH*, Li SJ, Zeng CS*. Evaluating effects of temperature, salinity, starvation and autotomy on molting success, molting interval and expression of ecdysone receptor in early juveniles of the mud crab, Scylla paramamosain. Journal of Experimental Marine Biology and Ecology. 2015, 464: 11-17.
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