王月华 - 中国医学科学院药物研究所 -

个人简介

教育背景 1991.9-1995.7 北京医科大学药物化学专业学士 2000.9-2003.7 中国协和医科大学药物所药理学专业硕士 2011.9-2014.7 北京大学药学院药理学专业博士工作经历 2003.7-至今在中国医学科学院药物研究所药物筛选中心工作。

研究领域

主要从事心脑血管及代谢性疾病药理学研究及新药研发。主要研究内容包括：（1）基于蛋白质非酶糖基化修饰的药物发现和评价。（2）基于线粒体功能障碍的药物发现和评价。（3）将现代提取分离技术、高通量筛选技术及现代药理学评价技术相结合，对中药复方进行系统研究。

近期论文

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1. Wang YH, Yu HT, Pu XP*, Du GH*. Protocatechualdehyde prevents methylglyoxal-induced mitochondrial dysfunction and AGEs-RAGE axis activation in Human lens epithelial cells. European Journal of Pharmacology, 2014, 738: 374-383. 2. Wang YH, Yu HT, Pu XP*, Du GH*. Myricitrin alleviates methylglyoxal-induced mitochondrial dysfunction and AGEs/RAGE/NFkB pathway activation in SH-SY5Y cells. J Mol Neurosci, 2014, 53: 562-572. 3. Zheng XY, Yang YF, Li W, Zhao X, Sun Y, Sun H, Wang YH, Pu XP*. Two xanthones from Swertia punicea with hepatoprotective activities in vitro and in vivo. Journal of Ethnopharmacology, 2014 Mar 29. pii: S0378-8741(14)00248-7. 4. Wang YH, Yu HT, Pu XP*, Du GH*. Baicalein prevents 6-Hydroxydopamine-induced mitochondrial Dysfunction in SH-SY5Y cells via inhibition of mitochondrial oxidation and up-regulation of DJ-1 protein expression. Molecules 2013, 18, 14726-14738. 5. Wang YH, Xuan ZH, Tian S, He GR, Du GH*, Myricitrin attenuates 6-hydroxydopamine-induced mitochondrial damage and apoptosis in PC12 cells via inhibition of mitochondrial oxidation. J Func Foods, 2013, 5: 337 –345. 6. Zhao X, Zhai S, An MS, Wang YH, Yang YF, Ge HQ, Liu JH, Pu XP*. Neuroprotective Effects of Protocatechuic Aldehyde against Neurotoxin-Induced Cellular and Animal Models of Parkinson’s Disease. PLoS One. 2013 Oct 18;8(10):e78220. 7. He XL, Wang YH, Bi MG*, Du GH*. Chrysin improves cognitive deficits and brain damage induced by chronic cerebral hypoperfusion in rats. Eur J Pharmacol, 2012, 680(1-3):41-48. 8. Gong LL, Fang LH, Wang HY, Peng JH, Si K, Zhu J, Han FF, Wang YH, Du GH*, Pei LX, Liu LH. Genetic risk factors for glucocorticoid-induced osteonecrosis: A meta-analysis. Steroids 78 (2013) 401–408. 9. Wang SB, Pang XB, Zhao Y, Wang YH, Zhang L, Yang XY, Fang LH, Du GH*. Salvianolic acid A protects rat brain from ischemic damage via soluble epoxide hydrolase inhibition. J Asian Natural Prod Res. 2012, 14(11): 1084-1092. 10. Zhang HA, Gao M, Zhang L, Zhao Y, Shi LL, Chen BN, Wang YH, Wang SB, Du GH*. Salvianolic acid A protects human SH-SY5Y neuroblastoma cells against H2O2-induced injury by increasing stress tolerance ability. Biochem Biophys Res Commun, 2012, 421(3): 479-483. 11. Gong LL, Peng JH, Han FF, Zhu J, Fang LH, Wang YH, Du GH*, Wang HY*, Liu LH*. Association of tissue plasminogen activator and plasminogen activator inhibitor polymorphism with myocardial infarction: A meta-analysis. Thromb Res, 2012, 130(3):e43-51. 12. Meng F, Liu R, Gao M, Wang Y, Yu X, Xuan Z, Sun J, Yang F, Wu C, Du G. Pinocembrin attenuates blood-brain barrier injury induced by global cerebral ischemia-reperfusion in rats. Brain Res, 2011, 1391: 93-101. 13. Yang B, Yu GL, Zhao X, Ren WN, Jiao GL, Fang LH, Wang YH, Du GH, Tiller C, Girouard G, Barrow CJ, Ewart H. S, Zhang JZ. Structural characterisation and bioactivities of hybrid carrageenan-like sulphated galactan from red alga Furcellaria lumbricalis. Food Chemistry. 2011, 124(1): 50-57. 14. Niu Y, Wang Y, Zou X, Yang X, Ma C, Lü Y, Zhou B, Yuan Y, Du G, Xu P*. Synthesis and preliminary evaluation of peptidomimetic inhibitors of human β-secretase. European Journal of Medicinal Chemistry, 2010, 45: 2089-2094. 15. Wang YH, Du GH. Ginsenoside Rg1 inhibits ß-secretase activity in vitro and protects against Aß-induced cytotoxicity in PC12 cells. Journal of Asian Natural Products Research, 2009, 11(7):604-612. 16. He XL, Wang YH, Gao M, Li XX, Zhan TT, Du GH. Baicalein protects rat brain mitochondria against chronic cerebral hypoperfusion-induced oxidative damage. Brain Research, 2009, 1249: 212-221. 17. Chao Ma, YueHua Wang, XiaoMing Yang, XiaoMin Zou , Yang Lü, GuanHua Du and Ping Xu*. Synthesis and activity of hydroxyethylene peptidomimetic inhibitors of human βsecretase. Journal of Chinese Pharmaceutical Sciences, 2008,17: 215. 18. 王月华，贺晓丽，杨海光，秦海林，杜冠华。小续命汤有效成分组对慢性脑缺血大鼠学习记忆能力及病理损伤的影响。中西医结合学报，2012，10(1)：91-99. 19. 王月华，贺晓丽，杨海光，秦海林，杜冠华。小续命汤有效成分组对局灶性脑缺血大鼠的作用。中国药学杂志，2012，47(3)：194-198。 20. 王月华,贺晓丽,李晓秀,秦海林,杜冠华*.小续命汤有效成分组对慢性脑缺血大鼠脑线粒体的保护作用. 中西医结合学报，2012，10(5)：569-576。