个人简介

PhD, The City University of New York, 1974 BA, Queens College, 1970 Postdoctoral Fellowship Postdoctoral Research Fellow, Ohio State University, 1974-1976 ACS Smissman Award (2015) Licensing Deal of the Year, Emory Office of Tech Transfer (2014) Fellow, Australian Academy of Technological Sciences and Engineering (2014) SEBio Shark Tank Winner (2014) Emory University Senate Lecture Series Panel (2013) Fellow, National Academy of Inventors (2013) Distinguished Alumni Award, The Ohio State University (2013) Uncommon Courage Award, Queens College (2012) Honorary Doctorate, Queens College (2012) Honorary Doctorate, University of Queensland, Australia (2012) Intellectual Property Legends Award, GA State University College of Law/J. Mack Robinson College of Business (2012) Emory 175 History Makers (2012) "Significant Event of 2011" Award, Emory University Office of Technology Transfer (2012) Thomas Jefferson Award, Emory University (2011) Fellow, American Chemical Society (2010-present) ACS Medicinal Chemistry Hall of Fame (2010) Herty Award (2005) Biomedical Industry Growth Award from the Georgia Biomedical Partnership (2003) Fellow of the American Association for the Advancement of Science (2002-present)

研究领域

Medicinal/Bioorganic/Synthetic Organic/Computational

CHEM 221: Organic Chemistry I CHEM 523: Advanced Organic Chemistry III (grad)

近期论文

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Baldwin, P.; Reeves, A.; Powell, K.; Napier, R.; Swimm, A.; Sun, A.; Giesler, K.; Bommarius, B.; Shinnick, T.; Snyder, J.; Liotta, D.; Kalman, D. Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis. Eur. J. of Med. Chem., 2015, 92: 693-699. Khatri, A.; Burger, P.; Swanger, S.; Hansen, K.; Zimmerman, S.; Karakas, E.; Liotta, D.; Furukawa, H.; Snyder, J.; Traynelis, S. Structural Determinants and Mechanism of Action of GluN2C-selective NMDA Receptor Positive Allosteric Modulator. Mol. Pharmacol., 2014, 86:548–560. Zhu, S.; Kisiel, W.; Lu, Y.; Petersen, L.; Ndungu, J.; Moore, T.; Parker, E.; Sun, A.; Liotta, D.; El-Rayes, B.; Brat, D.; Snyder, J.; Shoji, M. Tumor Angieogenesis Therapy Using Targeted Delivery of Pacclitaxel to the Vasculature of Breast Cancer Metastases. J. Drug Deliv., 2014 Zhu, S.; Kisiel, W.; Lu, Y.; Petersen, L.; Ndungu, J.; Moore, T.; Parker, E.; Sun, A.; Sarkaria, J.; Snyder, J.; Liotta, D.; Brat, D.; El-Rayes, B.; Shoji, M. Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody. J. Drug Target. 2014, 16:1-9. Strong, K.; Jing, Y.; Prosser, A.; Traynelis, S.; Liotta, D. NMDA receptor modulators: an updated patent review (2013-2014). Expert Opin. Ther. Patents., 2014, 24(12), 1349-1366. Zhou, T.; Ye, L.; Bai, Y.; Sun, A.; Cox, B.; Liu, D.; Li, Y.; Liotta, D.; Snyder, J.; Fu, H. Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: A novel curcumin analog. PLoS One., 2014, 9 (9), e107876 DiRaddo, J.; Miller, E.; Hathaway, H.; Grajkowska, E.; Wroblewska, B.; Wolfe, B.; Liotta, D.; Wroblewski, J. A Real-Time Method for Measuring cAMP Production Modulated by Gαi/o-Coupled Metabotropic Glutamate Receptors. J. Pharmacol.Exp. Ther., 2014, 349(3), 373–382. Hu, H.; Mao, S.; Bugrysheva, J.; Pruett, S.; Liotta, D.; Scott, J.; Snyder, J. Group A streptococcus inhibitors by high-throughput virtual screening. Eur. J. of Med. Chem., 2014, 82, 120-126. Cox, B.; Prosser, A.; Katzman, B.; Alcaraz, A.; Liotta, D.; Wilson, L.; Snyder, J. Anti-HIV Small Molecule Binding in the Peptide Subpocket of the CXCR4:CVX15 Crystal Structure. Chem. BioChem. 2014, 15(11), 1614-1620. Krumm S. A.; Yan, D.; Hovingh, E.; Evers, T. J.; Enkirch, T.; Prabhakar R.; Sun, A.; Manohar T.; Arrendale, R.; Painter, G.; Liotta, D..; Natchus, M.; von Messling, V.; Plemper, R. An Orally Available, Small-Molecule Polymerase Inhibitor Shows Efficacy Against a Lethal Morbillivirus Infection in a Large Animal Model. Sci. Transl. Med. 2014, 6(232), p. 232ra52. Zimmerman, S.; Khatri, A.; Garnier-Amblard, E.; Mullasseril, P.; Kurtkaya, N.; Gyoneva, S.; Hansen, K.; Traynelis, S.; Liotta, D. Design, Synthesis, and Structure–Activity Relationship of a Novel Series of GluN2C-Selective Potentiators. J. Med. Chem. 2014, 57 (6), 2334-2356. Prosser, A.; Liotta, D. One-pot transformation of esters to analytically pure ketones: methodology and application in process development. Tet. Lett. 2014. Article in Press. Truax, V.; Zhao, H.; Katzman, B.; Prosser, A.; Alcaraz, A..; Saindane, Manohar T.; Howard, R.; Culver, D.; Arrendale, R.; Gruddanti, P., Taylor J.E., Natchus, M.; Snyder, J.; Liotta, D.; Wilson, L. Discovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists. ACS Med. Chem. Lett. 2013, 4(11), 1025- 1030. Acker,T.; Khatri, A.; Vance, K.; Slabber, C.; Bacsa, J.; Snyder, J.; Traynelis, S.; Liotta, D. Structure-Activity Relationships and Pharmacophore Model of a Noncompetitive Pyrazoline Page 39 Class of GluN2C/GluN2D Selective Antagonists. J. Med. Chem. 2013, 56(16), 6434-6456. Moore, T.; Sana, K.; Yan, D.; Krumm, S.; Thepchatri,P.; Snyder, J.; Marengo, J.; Arrendale, R.; Prussia, A.; Natchus, M.; Liotta, D. Synthesis and Metabolic Studies of Host-Directed Inhibitors for Antiviral Therapy. ACS Med. Chem. Lett. 2013, 4(8), 762-767. Santangelo Freel, R.; Ogden, K..; Strong, K..; Khatri, A.; Chepiga, K..; Jensen, H.; Traynelis, S.; Liotta, D. Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-D-aspartate Receptors. J. Med. Chem. 2013, 56(13), 5351-5381. Brown, A.; Shi, Q.; Moore, T.; Yoon, Y.; Prussia, A.; Maddox, C.; Liotta, D.; Shim, H.; Snyder, J. Monocarbonyl Curcumin Analogues: Heterocyclic Pleiotropic Kinase Inhibitors That Mediate Anticancer Properties. J. Med. Chem. 2013, 56(9), 3456-3466. Moore, T.; Sana, K.; Yan, D.;Thepchatri, P.;Ndungu, J.;Sandaine, M.; Lockwood, M.; Natchus, M.; Liotta, D.;Plemper, R.; Snyder, J.; Sun, A. Asymmetric synthesis of host-directed inhibitors of myxovirus. Bellstein J. Org. Chem. 2013, 9(23), 197-203. Shi, Q.; Moore, T.; Yoon, Y.; Prussia, A.; Maddox, C.; Liotta, D.; Shim, H.; Brown, A.; Snyder, J. Monocarbonyl Curcumin Analogs: Heterocyclic Pleiotropic Kinase Inhibitors that Mediate Anti-Cancer Properties. J. Med. Chem. 2013, 56 (9), 3456-3466. Kim, J.; Wang, L.; Li, Y.; Becnel, K.; Frey, K.; Garforth, S.; Prasad, V.; Schinazi, R.; Liotta, D.; Anderson, K. Pre-steady State Kinetic Analysis of Cyclobutyl derivatives of 2’-deoxyadenosine 5’-triphosphate as inhibitors of HIC-1 transcriptase. Bioorg. Med. Chem. Lett. 2012, 22(12), 4064-4067.