Davies, Huw - Emory University - Department of Chemistry

个人简介

Huw M. L. Davies was born in Aberystwyth, Wales, UK. He received his B. Sc. degree from University College Cardiff, Wales and his Ph. D degree from the University of East Anglia. After a post-doctoral position at Princeton University, he joined the faculty at Wake Forest University. After being promoted to full professor he moved to the University at Buffalo, the State University of New York where he held the positions of UB Distinguished Professor and Larkin Professor of Organic Chemistry. In 2008 he moved to Emory University as the Asa Griggs Candler Professor of Organic Chemistry. Degrees PhD, Chemistry, University of East Anglia, UK, 1980 BSc, (Hon.) Class I, Chemistry, University College Cardiff, UK, 1977 Awards and Honors American Chemical Society Organic Division Chair (2005) Program Chair, Heterocycles Gordon Research Conference (2005) Member of the Editorial Board, Organic Syntheses (2008-present) Editorial Advisory Board, Chemical Society Reviews (2005-present) American Chemical Society Cope Scholar Award (2005) Fellow of the Royal Society of Chemistry (2007) Fellow of the American Chemical Society (2009) Fellow of the American Association for the Advancement of Science (2013) eEROS Reagent of the Year Award (2013) Fellow of the National Academy of Inventors (2015)

研究领域

Professor Davies’ research emphasizes the development of new enantioselective synthetic methods and their applications in total synthesis and drug discovery. His program covers design of chiral catalysts, carbenoid chemistry, development of new synthetic methodology, total synthesis of biologically active natural products, and development of chiral therapeutic agents. Many research groups have used his chiral dirhodium catalysts and several of them are commercially available. The impact of his carbenoid chemistry was recently recognized as he was chosen to be the recipient of the 2013 eEROS Reagent of the Year Award. A major current theme of his program is catalytic asymmetric C–H functionalization by means of rhodium-carbenoid induced C–H insertion. He is currently the Director of the NSF Phase II Center for Selective C-H Functionalization, which brings together 23 faculty members from 15 universities. Professor Davies is actively involved in the chemical community, having served as the Executive Officer of the 2003 National Organic Symposium, the 2005 Program Chair of the Gordon Conference on Heterocyclic Compounds, the 2005 Chair of the Organic Division of the American Chemical Society, and Co-Organizer of the ACS Organic Division yearly Assistant Professor Symposium at the Fall ACS meeting since 2006. Recent awards include the American Chemical Society Cope Scholar Award (2005), Fellow of the Royal Society of Chemistry (2007), Fellow of the American Chemical Society (2009), and Fellow of the American Association for the Advancement of Science (2012).

近期论文

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Rhodium-Catalyzed Intermolecular C–H Functionalization as a Key Step in the Synthesis of Complex Stereodefined β-Arylpyrrolidines June 21, 2018 Publications Authors: Robert W. Kubiak, II and Huw M. L. Davies Synthesis of [3a,7a]-Dihydroindoles by a Tandem Arene Cyclopropanation/3,5-Sigmatropic Rearrangement Reaction June 11, 2018 Publications Authors: Sidney M. Wilkerson-Hill, Brandon E. Haines, Djamaladdin G. Musaev, and Huw M. L. Davies J. Org. Chem., Article ASAP; DOI: 10.1021/acs.joc.8b00812 Blue light-promoted photolysis of aryldiazoacetates May 22, 2018 Publications Authors: Igor D. Jurberg and Huw M. L. Davies Chem. Sci., 2018, 9, 5112-5118; DOI:10.1039/C8SC01165F Formation of Tertiary Alcohols from the Rhodium-Catalyzed Reactions of Donor/Acceptor Carbenes with Esters April 11, 2018 Publications Liangbing Fu, Kevin Hoang, Cecilia Tortoreto, Wenbin Liu, and Huw M. L. Davies Org. Lett., 2018, 20 (8), pp 2399–2402; DOI: 10.1021/acs.orglett.8b00739 Harnessing the β-Silicon Effect for Regioselective and Stereoselective Rhodium(II)-Catalyzed C–H Functionalization by Donor/Acceptor Carbenes Derived from 1-Sulfonyl-1,2,3-triazoles April 11, 2018 Publications Authors: Zachary J. Garlets and Huw M. L. Davies Org. Lett., 2018, 20 (8), pp 2168–2171; DOI: 10.1021/acs.orglett.8b00427 Site-Selective Carbene-Induced C–H Functionalization Catalyzed by Dirhodium Tetrakis(triarylcyclopropanecarboxylate) Complexes December 18, 2017 Publications Author: Kuangbiao Liao, Wenbin Liu, Zachary L. Niemeyer, Zhi Ren, John Bacsa, Djamaladdin G. Musaev, Matthew S. Sigman, and Huw M. L. Davies ACS Catal. 2018, 8, 678–682 Site-selective and stereoselective functionalization of non-activated tertiary C–H bonds November 30, 2017 Publications Author: Kuangbiao Liao, Thomas C. Pickel, Vyacheslav Boyarskikh, John Bacsa, Djamaladdin G. Musaev & Huw M. L. Davies Nature 2017, 551, 609-613 CEN HIGHLIGHT: Catalyst activates tertiary C–H bonds Press Release: New catalyst controls activation of a carbon-hydrogen bond Collective Approach to Advancing C–H Functionalization September 11, 2017 Publications Author: Huw M. L. Davies and Daniel Morton ACS Cent. Sci. 2017, 3, 936–943 Rhodium- and Non-Metal-Catalyzed Approaches for the Conversion of Isoxazol-5-ones to 2,3-Dihydro-6H-1,3-oxazin-6-ones September 11, 2017 Publications Author: Igor D. Jurberg and Huw M. L. Davies Org. Lett. 2017, 19, 5158–5161. Rh(II)-Catalyzed Cyclopropanation of Furans and Its Application to the Total Synthesis of Natural Product Derivatives August 28, 2017 Publications Author: Verena Lehner, Huw M. L. Davies, and Oliver Reiser Org. Lett. 2017, 19, 4722–4725 Synthesis of Donor/Acceptor-Substituted Diazo Compounds in Flow and Their Application in Enantioselective Dirhodium-Catalyzed Cyclopropanation and C–H Functionalization June 5, 2017 Publications Author: Daniel Rackl, Chun-Jae Yoo, Christopher W. Jones, and Huw M. L. Davies Org. Lett. 2017, 19, 3055–3058 Scope of the Reactions of Indolyl- and Pyrrolyl-Tethered N-Sulfonyl-1,2,3-triazoles: Rhodium(II)-Catalyzed Synthesis of Indole- and Pyrrole-Fused Polycyclic Compounds March 30, 2017 Publications Author: Liangbing Fu, Huw M. L. Davies Org. Lett. 2017, 19, 1504–1507 Synthesis of 2,2,2,-Trichloroethyl Aryl- and Vinyldiazoacetates by Palladium-Catalyzed Cross-Coupling February 15, 2017 Publications Author: Liangbing Fu, Jeffrey D. Mighion, Eric A. Voight, Huw M. L. Davies Chem. Eur. J. 2017, 23,1–5 Metal-Free C–H Functionalization of Alkanes by Aryldiazoacetates February 7, 2017 Publications Author: Cecilia Tortoreto, Daniel Rackl, and Huw M. L. Davies Org. Lett. 2017, 19 (4), pp 770–773 Enantioselective Intermolecular C–H Functionalization of Allylic and Benzylic sp3 C–H Bonds Using N-Sulfonyl-1,2,3-triazoles June 22, 2016 Publications Author: Robert W. Kubiak II, Jeffrey D. Mighion, Sidney M. Wilkerson-Hill, Joshua S. Alford, Tetsushi Yoshidomi, and Huw M. L. Davies Org. Lett. 2016, 18 (13), 3118 Rapid Construction of a Benzo-Fused Indoxamycin Core Enabled by Site-Selective C−H Functionalizations May 20, 2016 Publications Authors: T. Aaron Bedell, Graham A. B. Hone, Damien Valette, Jin-Quan Yu, Huw M. L. Davies, Erik J. Sorensen Angew .Chem. Int. Ed. 2016, 55, 8270 Site-selective and stereoselective functionalization of unactivated C–H bonds May 12, 2016 Publications Authors: Kuangbiao Liao, Solymar Negretti, Djamaladdin G. Musaev, John Bacsa & Huw M. L. Davies Nature 2016, 533, 230–234 Rhodium(II)-Catalyzed C–H Functionalization of Electron-Deficient Methyl Groups April 11, 2016 Publications Authors: Liangbing Fu, David M. Guptill, and Huw M. L. Davies J. Am. Chem. Soc. 2016, 138 (18), pp 5761–5764 Recent Advances in C–H Functionalization January 15, 2016 Publications Authors: Huw M. L. Davies and Daniel Morton J. Org. Chem. 2016, 81 (2), pp 343–350 Rhodium-Catalyzed [4+3] Cycloaddition to Furans: Direct Access to Functionalized Bicyclo[5.3.0]decane Derivatives November 13, 2015 Publications Authors: Tanja Krainz, Sharon Chow, Natasa Korica, Paul V. Bernhardt, Glen M. Boyle, Peter G. Parsons, Huw M. L. Davies, and Craig M. Williams Eur. J. Org. Chem. 2016, 41–44