Martin Smith is a University Lecturer in Organic Chemistry at the University of Oxford, and the Old Members' Helen Martin Fellow at University College, Oxford. He is also co-director of the CDT in Synthesis for Biology & Medicine.
He came up to the University of Oxford from Middlesbrough in 1991 for his undergraduate studies, then worked with Professor George W. J. Fleet on the chemistry of carbohydrate amino acids, gaining his DPhil in 1999/2000. He then moved to Pembroke College, University of Cambridge as the Drapers Company Research Fellow, to work with Professor Steven V. Ley CBE FRS. In 2002 he began his tenure as a Royal Society University Research Fellow in the Department of Chemistry, University of Cambridge and Bristol Myers Squibb Fellow in Organic Chemistry at Pembroke College. The group moved to the University of Oxford in October 2008.
We are a synthetic organic chemistry group with wide-ranging interests in
synthesis, structure and asymmetric catalysis.
Our interests can be grouped into three main areas of research:
From Structure to Conformation (to Catalysis).
Total Synthesis of Complex Natural Products
Catalytic Enantioselective Synthesis of Atropisomeric Biaryls by a Cation-Directed O-Alkylation, J. D. Jolliffe, R. J. Armstrong & M. D. Smith, Nature Chem. 2017, in press: http://rdcu.be/oJDr
A Cascade Strategy Enables a Total Synthesis of Morphine, S. Chu, N. Münster, T. Balan & M. D. Smith, Angew. Chem. Int. Ed. 2016, 55, 14306-14309.
Enantioselective Synthesis of 4- and 6-Azaindolines by a Cation-Directed Cyclization, A. D. Lamb, P. D. Davey, R. W. Driver, A. L. Thompson & M. D. Smith, Org. Lett. 2016, 18, 5372-5375.
A Counterion-Directed Approach to the Diels-Alder Paradigm: Cascade Synthesis of Tricyclic Fused Cyclopropanes, E. Kiss, C. D. Campbell, R. W. Driver, J. D. Jolliffe, R. Lang, T. Sergieiva, S, Okovytyy, R. S. Paton & M. D. Smith. Angew. Chem. Int. Ed. 2016, 55, 13813-13817.
Catalytic Enantioselective synthesis of C1 and C2-symmetric spirobiindanones through counterion-directed enolate C-acylation, B. F. Rahemtulla, H. F. Clark & M. D.Smith, Angew. Chem. Int. Ed. 2016, 55, 13180-13183.
Torsional and Electronic factors control the C-H•••O interaction, R. W. Driver, T. D. W. Claridge, S. Scheiner & M. D. Smith, Chem. Eur. J. 2016, 22, 16513-16521
N-Benzyl quininium chloride, K. Badiola & M. D. Smith, Enyclopedia of Organic Reagents, 2016, Eds. P. L. Fuchs, J. W. Bode, A. B. Charette & T. Rovis, John Wiley & Sons, London.
Cation-Directed Enantioselective N-Functionalization of Pyrroles, R. J. Armstrong, M. D’Ascenzio, M. D. Smith, Synlett (S. V. Ley 70th Birthday Special Edition) 2016, 27, 6-10 6.
Cation-controlled enantio- and diastereoselective synthesis of indolines:
an autoinductive phase–transfer initiated 5-endo-trig process, K. Sharma, J. R. Wolstenhulme, P. P. Painter, D. Yeo, F. Grande-Carmona, C. P. Johnston, D. J. Tantillo & M. D. Smith, J. Am. Chem. Soc. 2015, 137, 13414-13424.
Catalytic Enantioselective Synthesis of Indanes by a Cation-Directed 5-Endo-Trig Cyclization, C. P. Johnston, A. Kothari, T. Sergeieva, S. I. Okovytyy, K. E. Jackson, R. S. Paton & M. D. Smith, Nature. Chem. 2015, 7, 171-176.
Bifunctional Crosslinking Ligands for Transthyretin, P. P. Mangione, S. Deroo, S. Ellmerich, V. Belotti, S. Kolstoe, S. P. Wood, C. V. Robinson, M. D. Smith, G. A. Tennant, R. L. Broadbridge, C. E. Council, J. R. Thurston, V. A. Steadman, A. K. Vong, C. J. Swain. M. B. Pepys & G. W, Taylor, Open Biology 2015, 5, 150105.
A Cascade Strategy Enables a Total Synthesis of Gephyrotoxin, S. Chu, S. Wallace & M. D. Smith, Angew. Chem. Int. Ed. 2014, 53, 13826-13829.
Catalytic Enantioselective Synthesis of Atropisomeric Biaryls: A Cation-Directed Nucleophilic Aromatic Substitution Reaction
R. J. Armstrong & M. D Smith, Angew. Chem. Int. Ed. 2014, 53, 12822-12825.
Enantioselective one-pot synthesis of dihydroquinolones via BINOL-derived Lewis acid catalysis, P. C. Knipe & M. D. Smith, Org. Biomol. Chem. 2014, 12, 5094-5097
Remote stereocontrol transmitted through helicity, C. P. Johnston & M. D. Smith, Angew. Chem. Int. Ed. 2014, 53, 3315-3317.
A cation-directed two-component cascade approach to enantioenriched pyrroloindolines. J. R. Wolstenhulme, A. Cavell, M. Gedicak, R. W. Driver & M. D. Smith, Chem. Commun. 2014, 50, 13585-13588.
Phase Transfer Catalysed Synthesis of Pyrroloindolines and Pyridoindolines by a Hydrogen Bond Assisted Isocyanide Cyclization Cascade, P. C. Knipe, M. Gredicak, A. Cernijenko, R. S. Paton & M. D. Smith, Chem. Eur. J., 2014, in press.