个人简介

Angela Russell gained an MChem degree from Oxford University in 2000, which included a Part II project on the synthesis and evaluation of ion channel mimics under the supervision of Paul Beer. She gained her DPhil from Oxford in 2004 under the joint supervision of Steve Davies and Tim Perera from Yamanouchi plc (now Astellas Pharma Inc.). The main focus of her work was using a pharmacophore modelling approach for the development of novel phosphatase inhibitors but also encompassed the development of novel asymmetric methodologies and the synthesis of molecules of biological importance. In March 2006 she became a Departmental Research Lecturer in Organic Chemistry and in August 2007 was awarded an RCUK Fellowship in Medicinal Chemistry jointly between the Departments of Chemistry and Pharmacology in Oxford.

研究领域

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Organic Chemistry

There are huge opportunities for chemistry to impact on biology and medicine. Progress can only occur through collaborations with the life sciences, where my group has already established highly successful projects in such areas as arylamine N-acetyltransferase inhibitors (for the treatment of tuberculosis and cancer; with Edith Sim) and protein tyrosine phosphatases (for the treatment of cancer, diabetes and inflammatory disorders). In addition we have recently begun a number of collaborations involving more fundamental approaches to chemical genetics, including the study of developmental signalling pathways such as Hedgehog and Wnt (with James Briscoe, Jean-Paul Vincent and Nobue Itasaki) and Bone Morphogenetic Protein (with Roger Patient).