研究领域

Organic Chemistry

I am Director of the Mass Spectrometry Research Facility in the Department of Chemistry, one of the UK’s leading mass spectrometry research facilities. I manage dedicated expertise and support staff who contribute to world class research across the department and the wider university. I am also a University Research Lecturer in Chemistry and Visiting Scholar at the Research Laboratory for Scientific Archaeology. My research group focuses on the development and application of novel analytical methods using chromatography coupled with mass spectrometry. We have a number of specific areas of interest centered around applications in chemical biology and metabolism. Projects currently include studies in cancer metabolism, animal and plant physiology, natural product analysis and isotopic applications in molecular and forensic archaeology. We collaborate with a wide range of researchers across Oxford, nationally and internationally. Internships, Part II and D.Phil. projects are also available. If you are interested in finding out more about the Mass Spectrometry Research Facility or research in the McCullagh group please contact James McCullagh.

近期论文

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Rachel Schiller1, Dr. Giuseppe Scozzafava2, Dr. Anthony Tumber2, Dr. James R. Wickens1, Jacob T. Bush1, Dr. Ganesha Rai3, Dr. Clarisse Lejeune1, Dr. Hwanho Choi1, Dr. Tzu-Lan Yeh1, Mun Chiang Chan1, Dr. Bryan T. Mott3, Dr. James S. O. McCullagh1, Dr. David J. Maloney3, Prof. Christopher J. Schofield1,* Dr. Akane Kawamura1,4,* A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1. ChemMedChem. DOI: 10.1002/cmdc.201300428 Tianshu Feng, Atsushi Yamamoto, Sarah E Wilkins, Elizaveta Sokolova, Luke A Yates, Martin Münzel, Pooja Singh, Richard J Hopkinson, Roman Fischer, Matthew E Cockman, Jake Shelley, David C Trudgian, Johannes Schödel, James S O McCullagh, Wei Ge, Benedikt M Kessler, Robert J Gilbert, Ludmila Y Frolova, Elena Alkalaeva, Peter J Ratcliffe, Christopher J Schofield, Mathew L Coleman. Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1.Molecular cell. Gong L, McCullagh JSO. Comparing ion-pairing reagents and sample dissolution solvents for ion-pairing reversed-phase liquid chromatography/electrospray ionization mass spectrometry analysis of oligonucleotides. Rapid Communications in Mass Spectrometry 28 (4):339-350 28 Feb 2014. Nalawade-Chavan S, McCullagh J, Hedges R. New hydroxyproline radiocarbon dates from sungir, Russia, confirm early mid upper palaeolithic burials in eurasia.. PLoS One 9 (1):e76896 2014. Larkin SJ, Near J, Kudari M, Khrapitchev A, Sibson N, Jezzard P, Pfeffer I, Al-Qahtani K, Schofield C, McCullagh J, et al.. Magnetic resonance spectroscopy for 2-hydroxyglutarate identifies IDH mutant gliomas. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. 39: 50-51. Mar 2013 (Conference) Author URL Nalawade-Chavan S, Hedges R, Ramsey CB, Higham T, McCullagh J, Bonsall C, Boroneanţ A. Compound-specific radiocarbon dating of essential and nonessential amino acids: Towards determination of dietary reservoir effects in humans. Radiocarbon 55(2-3):709-719 2013 Anat Marom, James S O McCullagh, Thomas F G Higham, Robert E M Hedges.Hydroxyproline dating: Experiments on the 14C analysis of contaminated and low collagen bones. RADIOCARBON, Vol 55, Nr 2–3, 2013, p 698–708 R.G. Webster, J. Cossins, D. Lashleya, S. Maxwell, W.W. Liu, J.R. Wickens, P. Martinez MartinezM, de Baets and D. Beeson. A mouse model of the slow channel myasthenic syndrome: Neuromuscular physiology and effects of ephedrine treatment. Experimental Neurology. Volume 248, October 2013, Pages 286–298 Yang M, Hardy AP, Chowdhury R, Loik ND, Scotti JS, McCullagh JS, Claridge TD, McDonough MA, Ge W, Schofield CJ.Substrate Selectivity Analyses of Factor Inhibiting Hypoxia-Inducible Factor.Angew Chem Int Ed Engl. 2013. Elena M Sanchez-Fernandez, Hanna Tarhonskaya, Khalid Al Qahtani, Richard J Hopkinson, James S.O. McCullagh, Christopher J Schofield, Emily Flashman. Investigations on the Oxygen Dependence of a 2-Oxoglutarate Histone Demethylase.Biochem J. 2013; 449, 491-6. Wei Ge, Alexander Wolf, Tianshu Feng, Chia-hua Ho, Rok Sekirnik, Adam Zayer, Nicolas Granatino, Matthew E. Cockman , Christoph Loenarz1 , Nikita D. Loik1 , Adam P. Hardy , Timothy D.W. Claridge , Refaat B. Hamed, Rasheduzzaman Chowdhury, Lingzhi Gong, David C. Trudgian, Miao Jiang, Mukram M. Mackeen, James S. Mccullagh, Yuliya Gordiyenko, Armin Thalhammer, Atsushi Yamamoto, Ming Yang, Yi Liu, Zhihong Zhang, Marion Schmidt-Zachmann, Benedikt M. Kessler, Peter J. Ratcliffe, Gail M. Preston, Mathew L. Coleman and Christopher J. Schofield. Oxygenase catalysed Ribosome Hydroxylation is conserved from Prokaryotes to Humans. Nature Chemical Biology. 2012; 8, 960-2. Marom A, McCullagh JSO, TFG Higham, Sinitsyn AA, REM Hedges. Single amino acid radiocarbon dating of Upper Palaeolithic modern humans. Proceedings of the National Academy of Sciences. 18th april 2012. Honch NV, McCullagh JS, Hedges REM. Variation of bone collagen amino acid δ13C values in archaeological humans and fauna with different dietary regimes: developing frameworks of dietary discrimination. Am. J. Phys. Anthropol. 2012; 148 (4): 495-511. Jean-Philippe Godin and James S. O. McCullagh. Current applications and challenges for liquid chromatography coupled to isotope ratio mass spectrometry (LC/IRMS). Rapid Communications in Mass Spectrometry. 2011, 25, 3019–3028 Anthony H. Lynch, James S. O. McCullagh, and Robert E. M. Hedges. Liquid chromatography/isotope ratio mass spectrometry measurement of δ13C of amino acids in plant proteins. Rapid Communications in Mass Spectrometry. 2011, 25, 2981–2988. Lingzhi Gong and James S.O. McCullagh. Analysis of oligonucleotides by hydrophilic interaction liquid chromatography coupled to negative ion electrospray ionization mass spectrometry. Journal of Chromatography A, 1218 (2011) 5480-5486. A.M. Pollard,* P. Ditchfield, J.S.O. McCullagh, T.G. Allen, M. Gibson, C. Boston, S. Clough, N. Marquez-Grant, and R.A. Nicholson. ‘‘These Boots Were Made For Walking’’: The Isotopic Analysis of a C4 Roman Inhumation From Gravesend, Kent, UK. Amercian Journal of Physical Anthropology. (2011): 146:446–456. Gaye-Siessegger, J., McCullagh J.S.O., Focken, U.The effect of dietary amino acid abundance and isotopic composition on the growth rate, metabolism and tissue d13C of rainbow trout. British Journal of Nutrition (2011), doi:10.1017/S0007114510005696 Monica Mantri, Nikita D. Loik, Refaat B. Hamed, Timothy D. W. Claridge, James S. O. McCullagh, Christopher J. Schofield. The 2-Oxoglutarate Dependent Oxygenase JMJD6 Catalyses Oxidation of Lysine Residues to give 5S-Hydroxylysine ResiduesChemBioChem, (2011), 12, 531-534.