个人简介

Gerald Muench started work at the University of Würzburg, Germany in 1995 and was then appointed Lecturer in the Department of Child and Adolescent Psychiatry in 1999. In 2000, he joined the Interdisciplinary Center for Clinical Research at the University of Leipzig. He left in 2004 to take up a position as Senior Lecturer at James Cook University in Townsville. In May 2008 Gerald was appointed as Associate Professor of Pharmacology in the School of Medicine at the University of Western Sydney, and he was promoted to Professor with effect from 1 January 2012. His major project focus is on Alzheimer's disease with a special emphasis on carbonyl stress in age-related and neurodegenerative processes, and also looking at brain inflammation as a major progression factor in Alzheimer's disease, now widely accepted. He is also looking to discover and identify novel anti-inflammatory and neuroprotective compounds from marine macroorganisms and tropical rainforest plants, a project started through James Cook University's "Enhancing life in the tropics". Gerald has served on the editorial boards of six international scientific journals and has been a consultant with Aventis, Roche Diagnostics, Merz, ASTA Medica/Degussa and Blackmores. His teaching philosophy is to show students how much fun the learning experience can be and define precisely what they need to know and understand when the standards are high.

研究领域

Pharmacology

Biochemistry Biotechnology Cell Biology Molecular Biology Molecular Genetics Pharmacology

近期论文

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Denzer, I., Muench, G., Pischetsrieder, M. and Friedland, K. (2016), 'S-allyl-l-cysteine and isoliquiritigenin improve mitochondrial function in cellular models of oxidative and nitrosative stress', Food Chemistry, vol 194 , pp 843 - 848. Denzer, I., Muench, G. and Friedland, K. (2016), 'Modulation of mitochondrial dysfunction in neurodegenerative diseases via activation of nuclear factor erythroid-2-related factor 2 by food-derived compounds', Pharmacological Research, vol 103 , pp 80 - 94. Johnson, A., Veljanoski, F., O'Doherty, P., Zaman, M., Petersingham, G., Bailey, T., Muench, G., Kersaitis, C. and Wu, M. (2016), 'Molecular insight into arsenic toxicity via the genome-wide deletion mutant screening of Saccharomces cerevisiae', Metallomics, vol 8, no 2 , pp 228 - 235. Steiner, N., Balez, R., Karunaweera, N., Lind, J., Muench, G. and Ooi, L. (2016), 'Neuroprotection of Neuro2a cells and the cytokine suppressive and anti-inflammatory mode of action of resveratrol in activated RAW264.7 macrophages and C8-B4 microglia', Neurochemistry International, vol 95 , pp 46 - 54. Jayne, T., Newman, M., Verdile, G., Sutherland, G., Muench, G., Musgrave, I., Moussavi Nik, S. and Lardelli, M. (2016), 'Evidence for and against a pathogenic role of reduced Y-secretase activity in familial Alzheimer's disease', Journal of Alzheimer's Disease, vol 52, no 3 , pp 781 - 799. Johnson, A., Veljanoski, F., O'Doherty, P., Zaman, M., Petersingham, G., Bailey, T., Muench, G., Kersaitis, C. and Wu, M. (2016), 'Revelation of molecular basis for chromium toxicity by phenotypes of Saccharomyces cerevisiae gene deletion mutants', Metallomics, vol 8, no 5 , pp 542 - 550. Moran, C., Tapp, R., Hughes, A., Magnussen, C., Blizzard, L., Phan, T., Beare, R., Witt, N., Muench, G. and [and three others], .. (2016), 'The association of Type 2 Diabetes Mellitus with cerebral gray matter volume is independent of retinal vascular architecture and retinopathy', Journal of Diabetes Research, vol 2016 . Gunawardena, D., Karunaweera, N., Lee, S., van der Kooy, F., Harman, D., Raju, R., Bennett, L., Gyengesi, E., Sucher, N. and Muench, G. (2015), 'Anti-inflammatory activity of cinnamon (C. zeylanicum and C. cassia) extracts - identification of e-cinnamaldehyde and o-methoxy cinnamaldehyde as the most potent bioactive compounds', Food & Function, vol 6, no 3 , pp 910 - 919. Low, M., Khoo, C., Muench, G., Govindaraghavan, S. and Sucher, N. (2015), 'An in vitro study of anti-inflammatory activity of standardised Andrographis paniculata extracts and pure andrographolide', BMC Complementary and Alternative Medicine, vol 15 . Moran, C., Muench, G., Forbes, J., Beare, R., Blizzard, L., Venn, A., Phan, T., Chen, J. and Srikanth, V. (2015), 'Type 2 diabetes, skin autofluorescence, and brain atrophy', Diabetes, vol 64, no 1 , pp 279 - 283. Kuhla, A., Ludwig, S., Kuhla, B., Muench, G. and Vollmar, B. (2015), 'Advanced glycation end products are mitogenic signals and trigger cell cycle reentry of neurons in Alzheimer's disease brain', Neurobiology of Aging, vol 36, no 2 , pp 753 - 761. Karunaweera, N., Raju, R., Gyengesi, E. and Muench, G. (2015), 'Plant polyphenols as inhibitors of NF-KB induced cytokine production : a potential anti-inflammatory treatment for Alzheimer's disease?', Frontiers in Molecular Neuroscience, vol 8 .