Saliba, Kevin - The Australian National University

个人简介

Kevin Saliba obtained a BSc (Chemistry) and a PhD (Pharmacology) from the University of Cape Town, South Africa. He was a post-doctoral fellow in the laboratory of Professor Kiaran Kirk at The Australian National University between 1997 and 2004. Late in 2004 he took up a lectureship at The Australian National University Medical School. He was promoted to senior lecturer in 2008.

研究领域

Medical Parasitology Clinical Pharmacology And Therapeutics Receptors And Membrane Biology Cell Metabolism Infectious Agents Basic Pharmacology Enzymes

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van Schalkwyk, D.A., Chan X.W.A., Misiano, P., Gagliardi, S., Farina, C. and Saliba, K.J. (2010) Inhibition of the Plasmodium falciparum V-type H+-ATPase by small molecule indole derivatives results in rapid parasite death. Biochemical Pharmacology 79:1291-1299 Spry, C. and Saliba, K.J. (2009) The human malaria parasite Plasmodium falciparum is not dependent on host coenzyme A biosynthesis. Journal of Biological Chemistry 284:24904-24913. Lehane, A.M., Marchetti, R.V., Spry, C., van Schalkwyk, D.A., Teng, R., Kirk K. and Saliba, K.J. (2007) Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite. Journal of Biological Chemistry 282:25395-25405 Saliba, K.J., Martin, R.E., Br?er, A., Henry, R.I., McCarthy, C.S., Downie, M.J., Allen, R.J.W., Mullin, K.A., McFadden, G.I., Br?er, S. and Kirk, K. (2006) Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite. Nature 433:582-585 Saliba, K.J., Allen, R.J.W., Zissis, S., Bray, P.G., Ward, S.A. and Kirk, K. (2003) Acidification of the malaria parasite’s digestive vacuole by a H+–ATPase and a H+–pyrophosphatase. Journal of Biological Chemistry 278:5605–5612 Saliba, K.J. and Kirk, K. (2001) H+–coupled pantothenate transport in the intracellular malaria parasite. Journal of Biological Chemistry 276:18115–18121 Reed, M.B., Saliba, K.J., Caruana, S.R., Kirk, K. and Cowman, A.F. (2000) Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 403:906–909 Saliba, K.J. and Kirk, K. (1999) pH regulation in the intracellular malaria parasite, Plasmodium falciparum: H+ extrusion via a V–type H+–ATPase. Journal of Biological Chemistry 274:33213–33219 Saliba, K.J., Horner, H.A. and Kirk, K. (1998) Transport and metabolism of the essential vitamin pantothenic acid in human erythrocytes infected with the malaria parasite Plasmodium falciparum. Journal of Biological Chemistry 273:10190–10195 Saliba, K.J., Folb, P.I. and Smith, P.J. (1998) Role for the Plasmodium falciparum digestive vacuole in chloroquine resistance. Biochemical Pharmacology 56:313–320.