Kirk, Kiaran - The Australian National University

个人简介

Kiaran Kirk carried out his PhD in the Department of Biochemistry at the University of Sydney (1985-1988). In 1989 he went to the Oxford University Laboratory of Physiology where he held an Oxford Nuffield Medical Fellowship, the Staines Medical Research Fellowship (Exeter College) and a Lister Institute Senior Research Fellowship. He returned to Australia in 1996 to head the Department of Biochemistry and Molecular Biology in the ANU Faculty of Science, holding this post until June 2009 when he took up the position of Director of the newly-created ANU Research School of Biology. In April 2014 Kiaran stepped down from this role to take up the position of Dean of the ANU College of Medicine, Biology and Environment.

研究领域

The physiology and biochemistry of the malaria parasite Mechanisms of drug action and drug resistance in the malaria parasite.

近期论文

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Kirk, K. (2015) Ion regulation in the malaria parasite. Annu. Rev. Microbiol. 69, 341–59 Spillman, N.J. and Kirk, K. (2015) The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs. Int.J. Parasitol.: Drugs and Drug Resistance. 5, 149-162 Marchetti, R.V., Lehane, A.M., Shafik, S.H., Winterberg, M., Martin, R.E. and Kirk, K. (2015) A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum. Nature Comm. 6, 6721 Jiménez-Díaz, M.B., Ebert, D., Salinas, Y., Pradhan, A., Lehane, A.M., Myrand-Lapierre, M., O’Loughlin, K.G., Shackleford, D.M., de Almeida, M.J.L., Carillo, A., Clark, J., Dennis, A.S.M., Diep, J., Deng, X., Duffy, S., Endsley, A.N., Guiguemde, G.F.A., Gomez-Lorenzo, M.G., Holbrook, G., Horst, J., Kim, C., Liu, J., Lee, M.C.S., Matheny, A., Martínez, M.S., Miller, G., Rodriguez-Alejandre, A., Sanz, L., Sigal, M., Spillman, N.J., Stein, P.D., Wang, Z., Zhu, F.,, Waterson, D., Knapp, S., Shelat, A.A., Fidock, D.A., Gamo, F.J., Charman, S.A., Mirsalis, J.C., Ma, H., Ferrer, S., Kirk, K., Angulo-Barturen, I., Kyle, D.E., DeRisi, J.L., Floyd, D.M., Guy, R.K. (2014) (+)-SJ733: A Clinical Candidate for Malaria that Acts Through ATP4 to Induce Rapid Host-Mediated Clearance of Plasmodium. Proc. Natl Acad. Sci. USA. 111, E5455- E5462 Vaidya, A.B., Morrisey , J.M., Zhang, Z., Das, S., Daly, T.M., Otto, T.D., Spillman, N.J., Wyvratt, M., Siegl, P., Marfurt, J., Wirjanata, G., Sebayang, B., Price, R.N., Chatterjee, A., Nagle, A., Stasiak, M., Charman, S.A., Angulo-Barturen, I., Ferrer, S., Jiménez-Díaz, M.B., Martínez, M.S., Gamo, F.J., Avery, V.M., Ruecker, A., Delves, M., Kirk, K., Berriman, M., Kortagere, S., Burrows, J., Fan, E. and Bergman, L.W. (2014) Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum. Nature Comm. 5, 5521 Tran, P., Brown, S., Mitchell, T., Matuschewski, K., McMillan, P., Kirk, K., Dixon, M. and Maier, A. (2014) A female-gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite. Nature Comm. 5, 4773 Spillman, N.J., Allen, R.J.W., McNamara, C.W., Yeung, B.K.S., Winzeler, E.A., Diagana, T.T. and Kirk, K. (2013) Na+ regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials. Cell Host & Microbe 13, 227-237 Winterberg, M., Rajendran, E., Baumeister, S., Bietz, S., Kirk, K. and Lingelbach K. (2012) Chemical activation of a high-affinity glutamate transporter in human erythrocytes and its implications for malaria-parasite-induced glutamate uptake. Blood, 119, 3604-3612 Martin, R.E., Marchetti, R.V., Cowan, A.I., Howitt, S.M., Br?er, S. and Kirk, K. (2009) Chloroquine transport via the malaria parasite’s ‘Chloroquine Resistance Transporter’. Science, 325, 1680-1682 Dean, S., Marchetti, R., Kirk, K. and Matthews, K.R. (2009) A surface transporter family conveys the differentiation signal in African trypanosomes. Nature, 459, 213-217 Lehane, A.M., Hayward, R., Saliba K.J. and Kirk, K. (2008) A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites. J. Cell Sci. 121, 1624-1632 Martin, R.E. and Kirk, K. (2007) Transport of the essential nutrient isoleucine in human erythrocytes infected with the malaria parasite Plasmodium falciparum. Blood 109, 2219-2226 Salibaa, K.J., Martina, R.E., Br?er, A., Henry, R.I., McCarthy, C.S., Downie, M.J., Allen, R.J.W., Mullin, K.A., McFadden, G.I., Br?erb, S. and Kirkb, K. (2006) Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite. Nature 443, 582-585 [a,b Equal contributions] Martin, R.E., Henry, R.I., Abbey, J.L., Clements, J.D, and Kirk, K. (2005) The 'permeome' of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparum. Genome Biol. 6, R26 Martin, R.E. and Kirk, K. (2004) The malaria parasite’s chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily. Mol. Biol. Evol. 21, 1938–1949 Allen, R.J.W. and Kirk, K. (2004) The membrane potential of the intraerythrocytic malaria parasite, Plasmodium falciparum. J. Biol. Chem., 279, 11264-11272 Kirk, K. (2001) Membrane transport in the malaria-infected erythrocyte. Physiol. Rev. 81, 495-537 Reed, M.B., Saliba, K.J., Caruana, S.R., Kirk, K. and Cowman, A.F. (2000) Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 403, 906-909.All publications