个人简介

男，博士，教授，博士生导师。江苏省青蓝工程青年骨干教师培养对象，南京农业大学农药 创制中心主任。研究方向是以天然活性化合物为先导，设计并合成新型高效、低毒、无公害 绿色农药，侧重于仿生型杀菌剂和除草剂的研发。研究内容包括新型绿色农药分子设计、药 物合成、结构表征、生物活性评价、构效关系分析、作用机制探索、剂型研制。先后主持国 家自然科学基金、国家 863 计划、国家科技支撑计划、中央高校基本科研业务费专项、江苏 省科技支撑项目、江苏省自然科学基金、江苏省农业科技自主创新资金等科研项目。承担过 草甘磷、戊环唑、甲环唑、丙环唑、S,S-氰戊菊酯、烯唑醇、烯效唑等 10 多个农药品种的 研发工作。申请国家发明专利 26 项，其中 13 项获得授权。发表学术论文 69 篇，其中 SCI 收录 38 篇。 教学信息 讲授课程：农药化学、农药合成与加工实验、现代农药合成实验。

研究领域

药物分子设计与合成；新农药创制

授权专利 [1] 杨春龙, 任正娇, 时松, 徐文琴, 李凌霞, 王坤瑶. 一种噻吩联吡咯啉酮类化合物、制备 方法及应用. 国家发明专利, 专利号:ZL201510606819.7, 授权日:2018-03-27. [2] 杨春龙, 徐文琴, 汪学伦, 任正娇, 王坤瑶, 李凌霞, 时松. 一种苯基吡咯联吡咯啉酮的 碳酸酯类衍生物、制备方法及应用. 国家发明专利, 专利号: ZL201510937475.8, 授权日: 2018-03-27. [3] 杨春龙, 赵正, 徐文琴, 丁伟杰, 张立志, 鲍倩倩, 任正娇. 一种哒嗪酮联吡咯烷酮衍生 物、制备方法及应用. 国家发明专利, 专利号:ZL201510204812.2. 授权日:2017-10-24. [4] 杨春龙, 鹿贵花, 陈敏, 王先锋, 冯玲玲, 王洋, 刘建波. 含吡咯烷二酮的甲氧基丙烯酸 甲酯类化合物、制备方法及其应用. 国家发明专利, 专利号:ZL201210524110.9. 授权日: 2016-04-06. [5] 杨春龙, 侯敏.一种含吡啶肼基团的吡咯烷二酮类化合物、制备方法及其应用. 专利号: ZL201210580212.2. 授权日:2016-07-06. [6] 杨春龙, 鹿贵花, 陈敏, 王先锋, 冯玲玲, 王洋, 刘建波. 一种含二氢异喹啉基团的吡咯 烷-2,4-二酮类化合物、制备方法及其应. 国家发明专利, 专利号:ZL201210524109.6. 申 请日:2012-12-10. 授权日:2016-12-21. [7] 杨春龙, 石清明. 一种含吡唑基团的吡咯啉酮类化合物、制备方法及其应用. 国家发明专 利, 专利号:ZL201210586507.0. 授权日:2016-12-28. [8] 杨春龙, 王先锋, 冯玲玲, 王洋, 陈敏, 胡颖, 王思思, 褚海彬, 王军军, 何睿, 黄霂. 一 种含取代苯肼的吡咯烷-2,4-二酮类化合物、制备方法及应用. 国家发明专利, 专利号:ZL 201110453110.X. 授权日:2015-03-24. [9] 杨春龙, 司腾飞, 孟范贵, 强胜, 王先锋, 朱兆勇, 3-酰基吡咯烷-2,4-二酮缩氨基脲类化 合物及其制备方法和用途. 国家发明专利, 专利号: ZL 201010202871.3. 授权日: 2012-09-05. [10] 杨春龙, 黄月芳, 王丽, 周亚岭, 王先锋, 朱兆勇, 一种葡萄糖二肽类化合物及其制备 方法和用途. 国家发明专利, 专利号:ZL200810124777.3. 授权日:2011-11-16. 科研项目 1. 国家自然科学基金，含取代苯肼的 tetramic acid 先导物的结构优化、杀菌活性及 3D-QSAR 研究，2018-2021，研究经费 60 万元，主持。 2. 国家重点研发计划（子课题），棉田广谱高效生物除草剂“丁羟咯酮”及衍生物新产品创 制，2017-2020，研究经费 20 万元，研究内容主持。 3. 江苏省农业科技自主创新资金项目，以赤霉病防控为核心技术的小麦区域化高产安全技 术方案，2015-2018，研究经费 30 万元，研究内容主持。 4. 中央高校基本科研业务费（重大专项），基于生物源活性分子先导的新农药创制—合理 设计、合成、生物活性与作用机制研究，2016-2018，研究经费 20 万元，参加。 5. 国家自然科学基金，基于天然产物 TeA 的新型吡咯啉酮类除草剂的设计、合成与筛选研 究，2011-2015，研究经费 62 万元，主持。 6. “十二五”国家科技支撑计划，绿色生态农药的研发与产业化—基于天然源先导物 Tenuazonic acid 的新型绿色生态除草剂的分子设计、合成及构效关系研究，2011-2015，研 究经费 30 万元，研究内容主持。 7. 江苏省科技支撑计划（农业部分），基于微生物源的创制杀菌剂氯肼烷酮及其对小麦赤 霉病的防控关键技术研究，2012-2015，研究经费 40 万元，主持。 8.“十二五”国家高技术研究发展计划（863 计划），植物生长调节剂、生物除草剂研究与产 品创制，2011-2015，研究经费 40 万元，研究内容主持。 9. 中央高校基本科研业务费，新型绿色农药的分子设计、生物活性及安全性评价研究， 2012-2014，研究经费 40 万元，主持。

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

[1] Wei-Jie Si, Xiao-Bin Wang, Min Chen, Meng-Qi Wang, Ai-Min Lu and Chun-Long Yang*. Design, synthesis, antifungal activity and 3D-QSAR study of novel pyrazole carboxamide and niacinamidederivatives containing benzimidazolemoiety[J].New JournalofChemistry, 2019, 43:3000-3010. [2] Jian Jiao, An Wang, Min Chen, Meng-Qi Wang, Chun-Long Yang*. Novel 5-chloro-pyrazole derivatives containing a phenylhydrazone moiety as potent antifungal agents synthesis, crystal structure, biological evaluationanda3D-QSAR study[J].NewJournalofChemistry, 2019,43: 6350-6360. [3] Xiaobin Wang, Xincan Fu, Min Chen, An Wang, Jinghua Yan, Yudong Mei, Mengqi Wang, Chunlong Yang*. Novel 1,3,5-thiadiazine-2-thione derivatives containing a hydrazide moiety: Design, synthesis and bioactive evaluation against phytopathogenic fungi in vitro and in vivo[J].ChineseChemicalLetters,2019,30:1419-1422. [4] Xiaobin Wang, Xincan Fu, Jinghua Yan, An Wang, Mengqi Wang, Min Chen, Chunlong Yang*, Yimin Song*. Design and synthesis of novel 2-(6-thioxo-1,3,5-thiadiazinan-3-yl)-N'-phenylacethydrazide derivatives as potential fungicides[J].MolecularDiversity,2019,23:573-583. [5] Min Chen, Ai-Min Lu, Ying Hu, Chun-Long Yang*. QSAR studies of phenylhydrazine substituted tetronic acid derivatives based on the 1H NMR and 13C NMR chemical shifts[J]. MagneticResonanceinChemistry,2019,57:285-293. [6] Xiaobin Wang, Zhengjiao Ren, Yudong Mei, Menghan Liu, Min Chen, Weijie Si, Chunlong Yang* and Yimin Song*. Design, synthesis, and antifungal activity of 3-(thiophen-2-yl)1,5-dihydro-2H-pyrrol-2-one derivatives bearing a carbonic ester group[J]. Journal of HeterocyclicChemistry,2019,56:165-171. [7] Ling-Xia Li, Jian Jiao, Xiao-Bin Wang, Min Chen, Xin-Can Fu, Wei-Jie Si and Chun-Long Yang*. Synthesis, characterization, and antifungal activity of novel benzo[4,5]imidazo[1,2d][1,2,4]triazinederivatives[J].Molecules,2018,23(4),746. [8] Xiaobin Wang, Zhengjiao Ren, Mengqi Wang, Min Chen, Aiming Lu, Weijie Si, Chunlong Yang*. Design and synthesis of novel 3-(thiophen-2-yl)-1,5-dihydro-2H-pyrrol-2-one derivatives bearing a hydrazone moiety as potential fungicides[J]. Chemistry Central Journal, 2018,12,83,1-12. [9] Wei-Jie Si, Min Chen, Xue-Lun Wang, Meng-Qi Wang, Jian Jiao, Xin-Can Fu, and Chun-Long Yang*. Synthesis and insecticidal activity of novel benzothiazole derivatives containingthecoumarinmoiety[J].Arkivoc,2018,vii: 86-99. [10] Xiaobin Wang, Mengqi Wang, Jinghua Yan, Min Chen, An Wang, Yudong Mei, Weijie Si, ChunlongYang*. Design, synthesis and 3D-QSAR of novel quinazolin-4(3H)-one derivatives containing a hydrazide moiety as potential fungicides[J]. ChemistrySelect, 2018, 3: 10663-1069. [11] Jun-Jun Wang, Wei-Jie Si, Min Chen, Ai-Min Lu, Wei-Hua Zhang*, Chun-Long Yang*. Synthesis and fungicidal activity of phenylhydrazone derivatives containing two carbonic acid estergroups[J].J.Pestic. Sci.,2017,42(3):84-92. [12] Wen-Qin Xu, Min Chen, Kun-Yao Wang, Zheng-Jiao Ren, Ai-Min Lu and Chun-Long Yang*. Synthesis, characterization, and antifungal activity of phenylpyrrole-substituted tetramicacidsbearingcarbonates[J].Molecules,2016,21,355. [13] Lizhi Zhang, Zhengjiao Ren, Aimin Lu, Zheng Zhao, Wenqin Xu, Qianqian Bao, Weijie Ding, Chunlong Yang*. Synthesis, biological activity and 3D-QSAR study of novel pyrrolidine-2,4-dione derivatives containing N-substituted phenylhydrazine moiety[J]. Chem. Res.Chin.Univ.,2015,31(2):228-234. [14] Chen Min, Yang Chun-Long*. Synthesis, crystal structure and biological activity of 5-(2-methylphenyl)-1,3,4-oxadiazol-2(3H)-one derivatives[J]. Chinese J. Struct. Chem., 2015, 34(2):189-196. [15] Ying Hu, Li-Zhi Zhang, Zheng-Jiao Ren, Zheng Zhao, Wen-Qin Xu and Chun-Long Yang*. Synthesis and antifungal activity of novel furan-2,4-dione derivatives containing substituted phenylhydrazinemoiety[J].J.Chin.Chem.Soc.,2015,62,495-500. [16] Wang Xian-Feng, Chen Min, Zhang Li-Zhi, Zhao Zheng, Yang Chun-Long*. Synthesis, characterization and bioactivity of novel 5,6-dihydropyrrolo[3,4-c]pyrazol-4-(1H)one derivatives[J].HeterocyclicCommunications,2015,21:361-366. [17] Ying Hu, Junjun Wang, Aimin Lu, Chunlong Yang*. Synthesis, characterization, antifungal evaluation and 3D-QSAR study of phenylhydrazine substituted tetronic acid derivatives[J]. Bioorg.Med.Chem.Lett.,2014,24:3772-3776. [18] Gui-Hua Lu, Hai-Bin Chu, Min Chen, Chun-LongYang*. Synthesis and bioactivity of novel strobilurin derivatives containing the pyrrolidine-2,4-dione moiety[J]. Chinese Chemical Letters,2014,25:61–64. [19] Min Chen, Xian-Feng Wang, Si-Si Wang, Yi-Xiao Feng, Feng Chen, Chun-Long Yang*. Synthesis, characterization and fungicidal activities of novel fluorinated 3,5-disubstituted4H-1,2,4-triazol-4-amines[J].JournalofFluorineChemistry,2012,135:323-329. [20] Bao Feng Han, Qing Ming Shi, Xian Feng Wang, Jian Bo Liu, Sheng Qiang, Chun Long Yang*. Synthesis and bioactivity of novel 3-(1-hydroxyethylidene)-5-substituted-pyrrolidine2,4-dionederivatives[J].ChineseChemicalLetters,2012,23:1023-1026. [21] Xiao-Qian Zheng, Bao-Feng Han, Xian-Feng Wang, Sheng Qiang, Chun-Long Yang*. Synthesis and bioactivity of novel (Z,E)-1-(substituted phenyl)-3-[α-(alkyloxyimino) -benzylidene]pyrrolidine-2,4-dione derivatives[J]. Heterocycl. Commun., 2011, 17(1-2): 73-78. [22] Xian-Feng Wang, Teng-Fei Si, Qing-Bin Li, Zhao-Yong Zhu, Xian-Jie Zhu, Sheng Qiang, and Chun-Long Yang*. Synthesis, characterization and biological activity of novel (5-RS,6S)-5-sec-butyl-3-(1-substituted-amino)ethylidene-1H-pyrrolidine-2,4-diones[J]. ARKIVOC, 2010,(ii): 31-48. [23] Zhao-Yong Zhu, Xian-Feng Wang, Fan-Gui Meng, Qing-Bin Li, Xiao-Qian Zheng, Sheng Qiang, and Chun-LongYang*. Synthesis, Characterization, and BiologicalActivities of Novel (Z)-3-((E)-1-(Alkyloxyimino)Ethyl)-5-Arylidene-4-Hydroxypyrroline-2-One Derivatives[J]. J. HeterocyclicChem.,2010,47:1328-1334. [24] ZhaoYong Zhu, Qing Ming Shi, Bao Feng Han, Xian Feng Wang, Sheng Qiang, Chun Long Yang*. Synthesis, Characterization and Biological Activities of Novel (E)-3-(1(Alkyloxyamino)ethylidene)-1-alkylpyrrolidine-2,4-dione Derivatives[J]. Bull. Korean Chem. Soc.,2010,31(9):2467-2472.