Jones, David - The Australian National University

个人简介

David Jones obtained his B.Sc. (Hons) and PhD at the Department of Genetics, University of Adelaide working on the genetics of the interaction between flax and the flax rust fungus Melampsora lini. He was then awarded a Charles John Everard Postdoctoral Fellowship in the Department of Plant Pathology, Waite Agricultural Research Institute, University of Adelaide where he worked on the biological control of crown gall. His work led to the first commercial release of a genetically modified bacterium, subsequently marketed as NoGall. He was then offered a postdoctoral fellowship in The Sainsbury Laboratory, John Innes Centre, Norwich, where he worked on the genetic and molecular basis of the interaction between tomato and the leaf mould fungus Cladopsorium fulvum. His work led to the isolation of the tomato Cf-9 gene, one of the first plant disease resistance genes cloned. In 1996, he returned to Australia to set up his own lab in the Research School of Biological Sciences (now the Research School of Biology) at The Australian National University, where he continues work on the molecular basis of disease resistance in tomato (leaf mould and Fusarium wilt resistance) and flax (flax rust resistance).

研究领域

Protein trafficking Plant physiology Signal transduction Gene expression (incl. microarray and other genome-wide approaches) Genome structure and regulation Receptors and membrane biology Plant cell and molecular biology Plant pathology Genetics

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Takemoto, D., Rafiqi, M., Hurley, U., Lawrence, G.J., Bernoux, M., Hardham, A.R., Ellis, J.G., Dodds, P.N. and Jones, D.A. 2012. N-terminal motifs in some plant disease resistance proteins function in membrane attachment and contribute to disease resistance. Molecular Plant-Microbe Interactions 25:379-392. Rafiqi, M., Gan, P.H.P., Ravensdale, M., Lawrence, G.J., Ellis, J.G., Jones, D.A., Hardham, A.R., and Dodds, P.N. 2010. Internalization of flax rust avirulence proteins into flax and tobacco cells can occur in the absence of the pathogen. Plant Cell 22:2017-2032. Wulff, B.B.H., Chakrabarti, A., and Jones, D.A. 2009. Recognitional specificity and evolution in the tomato-Cladosporium fulvum pathosystem. Molecular Plant-Microbe Interactions 22:1191-1202. Chakrabarti, A., Panter, S.N., Harrison, K., Jones, J.D.G., and Jones, D.A. 2009. Regions of the Cf-9B disease resistance protein able to cause spontaneous necrosis in Nicotiana benthamiana lie within the region controlling pathogen recognition in tomato. Molecular Plant-Microbe Interactions 22:1214-1226. Wulff, B.B., Heese, A., Tomlinson-Buhot, L., Jones, D.A., de la Pe?a, M., and Jones, J.D.G. 2009. The major specificity-determining amino acids of the tomato Cf-9 disease resistance protein are at hypervariable solvent-exposed positions in the central leucine-rich repeats. Molecular Plant-Microbe Interactions 22:1203-1213 Lim, G.T.T., Wang, G.P., Hemming, M.N., McGrath, D.J., and Jones, D.A. 2008. High resolution genetic and physical mapping of the I-3 region of tomato chromosome 7 reveals almost continuous microsynteny with grape chromosome 12 but interspersed microsynteny with duplications on Arabidopsis chromosomes 1, 2 and 3. Theoretical and Applied Genetics 118:57-75. Barker, C.L., Talbot, S.J., Jones, J.D.G., and Jones D.A. 2006. A tomato mutant that shows stunting, wilting, progressive necrosis and constitutive expression of defense genes contains a recombinant Hcr9 gene encoding an autoactive protein. Plant Journal 46:369-384. Barker, C.L., Baillie, B.K., Hammond-Kosack, K.E., Jones, J.D.G., and Jones, D.A. 2006. Dominant-negative interference with defence signalling by truncation mutations of the tomato Cf-9 disease resistance gene. Plant Journal 46:385-399. Takemoto, D., and Jones, D.A. 2005. Membrane release and destabilization of Arabidopsis RIN4 following cleavage by Pseudomonas syringae AvrRpt2. Molecular Plant-Microbe Interactions 18: 1258-1268. Benghezal, M., Wasteneys, G.O., and Jones, D.A. 2000. The C-terminal dilysine motif confers endoplasmic reticulum localization to type I membrane proteins in plants. Plant Cell 12:1179-1201. Jones, D.A., Thomas, C.M., Hammond-Kosack, K.E., Balint-Kurti, P.J., and Jones, J.D.G. 1994.Isolation of the tomato Cf-9 gene for resistance to Cladosporium fulvum by transposon tagging. Science 266:789-793