研究领域

Synthesis

Deborah Longbottom is responsible for building up graduate level training in the Department of Chemistry, including academic and industrial lectures and workshops, symposia, industrial forums, placement opportunities and careers sessions with Departmental alumni. Prior to this, she was a Teaching Fellow for undergraduates in the Department of Chemistry for several years and still retains some key responsibilities in this area, among which are the Part IA Laboratory and her first year organic chemistry course, as well as her final year 'Medicinal Chemistry' lectures and involvement with several outreach events for school age children. Her research background comprises organic synthesis and methodology and she spent many years as a Senior Research Associate in the group of Professor Steven V. Ley, which followed post-doctoral studies with Professor K. C. Nicolaou and experience in the pharmaceutical industry. Her most recent research involvement has been through a fruitful collaboration with the O'Reilly group at Warwick University, which has led to interesting investigations on the synthesis and utility of amino-acid functionalised polymers formed by RAFT polymerisation. Further explorations in this area are ongoing.

近期论文

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Tuning the Catalytic Activity of L-Proline Functionalised Hydrophobic Nanogel Particles in Water A. Lu, P. Cotanda, J. P. Patterson, D. A. Longbottom and R. K. O’Reilly, ChemSci., 2013, 4, 965. Immobilization of MacMillan Catalyst via Controlled Radical Polymerisation: Catalytic Activity and Reuse B. Moore, A. Lu, D. A. Longbottom and R. K. O’Reilly, Polym. Chem., 2013, 4, 2304. Aldol Reactions Catalysed by L-Proline Functionalised Polymeric Nanoreactors in Water A. Lu, P. Cotanda, J. P. Patterson, D. A. Longbottom and R. K. O’Reilly, Chem. Commun., 2012, 48, 9699. L-Proline Functionalized Polymers Prepared by RAFT Polymerization and their Assemblies as Supported Organocatalysts A. Lu, T. Smart, T. Epps, III, D. A. Longbottom and R. K. O'Reilly, Macromolecules, 2011, 44, 7233. Organocatalytic Tuneable Amino Acid Polymers Prepared by Controlled Radical Polymerization A. C. Evans, A. Lu, C. Ondeck, D. A. Longbottom and R. K. O'Reilly, J. Polym. Sci., Part A, 2009, 47, 6814. Highly Diastereoselective Desymmetrisation of Cyclic meso-Anhydrides and Derivatisation for Use in Natural Product Synthesis A. C. Evans, D. A. Longbottom, M. Matsuoka, J. E. Davies, R. Turner, V. Franckevicius and S. V. Ley, Org. Biomol. Chem., 2009, 7, 747. Practical Organocatalysis Using (S)- and (R)-5-Pyrrolidin-2-yl-1H-tetrazoles: A Review D. A. Longbottom, V. Franckevicius, S. Kumarn, A. J. Oelke, V. Waschlowski and S. V. Ley, Aldrichimica Acta, 2008, 41, 3. Practical Synthesis of (S)-5-Pyrrolidin-2-yltetrazole, Incorporating Efficient Protecting Group Removal by Flow-reactor Hydrogenolysis V. Franckevicius, K. R. Knudsen, M. Ladlow, D. A. Longbottom and S. V. Ley, Synlett, 2006, 889. Total Synthesis and Biological Evaluation of Halipeptins A and D and Analogues K. C. Nicolaou, D. E. Lizos, D. W. Kim, D. Schlawe, R. G. de Noronha, D. A. Longbottom, M. Rodriguez, M. Bucci and G. Cirino, J. Am. Chem. Soc., 2006, 128, 4460. New Uses for the Burgess Reagent in Chemical Synthesis: Methods for the Facile and Stereoselective Formation of Sulfamidates, Glycosylamines, and Sulfamides K. C. Nicolaou, S. A. Snyder, D. A. Longbottom, A. Z. Nalbandian and X. Huang, Chem. Eur. J., 2004, 10, 5581. Total Synthesis of Polycephalin C and Determination of Absolute Stereochemistry at the 3'',4'' Ring Junction D. A. Longbottom, A. J. Morrison, D. J. Dixon and S. V. Ley, Angew. Chem. Int. Ed., 2002, 41, 2786. Total Synthesis of the Plasmoidal Pigment Physarorubinic Acid, a Polyenoyltetramic Acid D. J. Dixon, S. V. Ley and D. A. Longbottom, J. Chem. Soc., Perkin Trans. 1, 1999, 2231.