研究领域

Synthesis/Biological/Materials

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 4 years we have completed the total synthesis of 38 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 140 completed total syntheses. In addition to our research on natural product synthesis, we have the Innovative Technology Centre (ITC); a new state-of-the-art flow chemistry facility. Our group is also part of the Cambridge PhD Training Programme in Chemical Biology and Molecular Medicine.

近期论文

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Development of a flow method for the hydroboration/oxidation of olefins. JA Souto, RA Stockman, SV Ley – Org Biomol Chem (2015) (DOI: 10.1039/c5ob00170f) Back pressure regulation of slurry-forming reactions in continuous flow BJ Deadman, DL Browne, IR Baxendale, SV Ley – Chemical Engineering and Technology (2015) 38, 259 (DOI: 10.1002/ceat.201400445) Flow chemistry as a discovery tool to access sp2-sp3 cross-coupling reactions via diazo compounds DN Tran, C Battilocchio, S-B Lou, JM Hawkins, SV Ley – Chem. Sci. (2015) 6, 1120 (DOI: 10.1039/C4SC03072A) Flow chemistry: Intelligent processing of gas-liquid transformations using a tube-in-tube reactor M Brzozowski, M O'Brien, SV Ley, A Polyzos – Accounts of Chemical Research (2015) 48, 349 (DOI: 10.1021/ar500359m) Cyclopropanation using flow-generated diazo compounds. NM Roda, DN Tran, C Battilocchio, R Labes, RJ Ingham, JM Hawkins, SV Ley – Org Biomol Chem (2015) 13, 2550 (DOI: 10.1039/c5ob00019j) Organic Synthesis: March of the Machines. SV Ley, DE Fitzpatrick, RJ Ingham, RM Myers – Angew Chem Int Ed Engl (2015) 54, n/a (DOI: 10.1002/anie.201410744) Back Pressure Regulation of Slurry-Forming Reactions in Continuous Flow BJ Deadman, DL Browne, IR Baxendale, SV Ley – Chemical Engineering and Technology (2015) 38, 259 (DOI: 10.1002/ceat.201400445) Total syntheses of linear polythiazole/oxazole plantazolicin A and its biosynthetic precursor plantazolicin B ZE Wilson, S Fenner, SV Ley – Angew Chem Int Ed Engl (2015) 54, 1284 (DOI: 10.1002/anie.201410063) Process intensification for the continuous flow hydrogenation of ethyl nicotinate T Ouchi, C Battilocchio, JM Hawkins, SV Ley – Organic Process Research and Development (2014) 18, 1560 (DOI: 10.1021/op500208j) A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences RJ Ingham, C Battilocchio, DE Fitzpatrick, E Sliwinski, JM Hawkins, SV Ley – Angew Chem Int Ed Engl (2015) 54, 144 (DOI: 10.1002/anie.201409356) The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions S Glöckner, DN Tran, RJ Ingham, S Fenner, ZE Wilson, C Battilocchio, SV Ley – Org Biomol Chem (2015) 13, 207 (DOI: 10.1039/c4ob02105c) Design and application of a low-temperature continuous flow chemistry platform JA Newby, DW Blaylock, PM Witt, JC Pastre, MK Zacharova, SV Ley, DL Browne – Organic Process Research and Development (2014) 18, 1211 (DOI: 10.1021/op500213j) Reconfiguration of a continuous flow platform for extended operation: Application to a cryogenic fluorine-directed ortho-lithiation reaction JA Newby, DW Blaylock, PM Witt, RM Turner, PL Heider, BH Harji, DL Browne, SV Ley – Organic Process Research and Development (2014) 18, 1221 (DOI: 10.1021/op500221s) A general continuous flow method for palladium catalysed carbonylation reactions using single and multiple tube-in-tube gas-liquid microreactors U Gross, P Koos, M O'Brien, A Polyzos, SV Ley – European Journal of Organic Chemistry (2014) 2014, 6418 (DOI: 10.1002/ejoc.201402804) Flow chemistry meets advanced functional materials. RM Myers, DE Fitzpatrick, RM Turner, SV Ley – Chemistry (2014) 20, 12348 (DOI: 10.1002/chem.201402801) Expedient preparation of nazlinine and a small library of indole alkaloids using flow electrochemistry as an enabling technology MA Kabeshov, B Musio, PR Murray, DL Browne, SV Ley – Organic Letters (2014) 16, 4618 (DOI: 10.1021/ol502201d) Regioselective preparation of saturated spirocyclic and ring-expanded fused pyrazoles RR Merchant, DM Allwood, DC Blakemore, SV Ley – J Org Chem (2014) 79, 8800 (DOI: 10.1021/jo501624t) Highly regioselective lithiation of pyridines bearing an oxetane unit by n-butyllithium G Rouquet, DC Blakemore, SV Ley – Chemical communications (Cambridge, England) (2014) 50, 8908 (DOI: 10.1039/C4CC03766A) Preparation of unsymmetrical ketones from tosylhydrazones and aromatic aldehydes via formyl C-H bond insertion. DM Allwood, DC Blakemore, SV Ley – Organic Letters (2014) 16, 3064 (DOI: 10.1021/ol5011714) Continuous flow chemistry: a discovery tool for new chemical reactivity patterns. J Hartwig, JB Metternich, N Nikbin, A Kirschning, SV Ley – Org Biomol Chem (2014) 12, 3611 (DOI: 10.1039/c4ob00662c)