个人简介

I was born in New Zealand in 1965 and moved to Northern Ireland with my parents in 1969. My early education was at Portstewart Primary School and Coleraine Academical Institution. Following an undergraduate degree in Natural Sciences at Churchill College (1983-1986), I stayed at the University of Cambridge for a PhD with Professor Jeremy Sanders in the University Chemical Laboratory (1986-1989). I was appointed to a Lecturership at the University of Otago in New Zealand in 1989. I moved to the University of Sheffield in 1991 and was promoted to Professor of Chemistry in 1997. In 2014, I returned to the University of Cambridge as the Herchel Smith Professor of Organic Chemistry and Fellow of Emmanuel College. Awards RSC Meldola Medal (1992); Lister Institute Research Fellow (1994-1999); Zeneca Research Award in Organic Chemistry (1995); RSC Corday-Morgan Medal (1999); EPSRC Senior Research Fellow (2005-2010); RSC Tilden Prize (2009); RSC Physical Organic Chemistry Award (2011)

研究领域

Synthesis

Weak intermolecular forces provide the key to understanding the relationship between structure and function in chemistry, biology and materials science. Through the study of synthetic supramolecular systems, we are developing a quantitative description of the chemistry of weak non-covalent interactions. Physical Organic Chemistry of Non-Covalent Interactions. Fundamental investigations of the nature of intermolecular interactions will establish a sound quantitative basis for predicting the thermodynamic contributions of the many different factors that influence the behaviour of complex systems. The synthetic supramolecular systems and double mutant cycle approaches that we have developed provide the ideal vehicle for the systematic study and quantitative determination of the thermodynamic properties of non-covalent interactions. Functional Supramolecular Assemblies. Nature has long inspired chemists with glimpses of the spectacular levels of sophistication and functionality that are possible with well-organised molecular systems. The development of quantitative non-covalent chemistry provides the supramolecular design tools required to tackle synthetic systems with comparable properties: current projects focus on new classes of evolvable synthetic polymers for recognition, sensing and catalysis. Solvation Systems Chemistry. Understanding solvent effects is one of the great unsolved problems in chemistry, and our combined experimental and theoretical approach is developing a conceptual framework for a general quantitative understanding of molecular recognition in different solvent environments. We are developing new supramolecular approaches to studying solvation phenomena and their role in determining the properties of molecular systems in solution. Modeling Biomolecular Interactions. We use energy calculations in conjunction with experimental data such as crystallographic databases to investigate the factors that determine the relationship between chemical structure, three-dimensional structure and the organisation of complex systems. The development of these models will provide tools for understanding the properties and function of a wide range of molecular systems, from the solvation of small molecules to the programming of molecular organisation in the nucleus by DNA sequence. Techniques involved in our research include organic synthesis, coordination chemistry, NMR spectroscopy, mass spectrometry, X-ray crystallography, high-throughput physical organic chemistry, structural and thermodynamic characterisation of intermolecular complexes, molecular design, molecular modelling, biophysics, bioinformatics and computer programming.

近期论文

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An Interconverting Family of Coordination Cages and a meso -Helicate; Effects of Temperature, Concentration, and Solvent on the Product Distribution of a Self-Assembly Process W Cullen, CA Hunter, MD Ward – Inorg Chem (2015) 150220162319007 (DOI: 10.1021/ic502780b) The flexibility-complementarity dichotomy in receptor-ligand interactions H Sun, CA Hunter, EM Llamas – Chem. Sci. (2015) 6, 1444 (DOI: 10.1039/C4SC03398A) The roughness of the protein energy landscape results in anomalous diffusion of the polypeptide backbone M Volk, L Milanesi, JP Waltho, CA Hunter, GS Beddard – Physical chemistry chemical physics : PCCP (2015) 17, 762 (DOI: 10.1039/c4cp03058c) Applications of dynamic combinatorial chemistry for the determination of effective molarity M Ciaccia, I Tosi, L Baldini, R Cacciapaglia, L Mandolini, S Di Stefano, CA Hunter – Chem. Sci. (2015) 6, 144 (DOI: 10.1039/C4SC02347A) pH-dependent binding of guests in the cavity of a polyhedral coordination cage: reversible uptake and release of drug molecules W Cullen, S Turega, CA Hunter, MD Ward – Chem. Sci. (2015) 6, 625 (DOI: 10.1039/C4SC02090A) Mapping the Internal Recognition Surface of an Octanuclear Coordination Cage Using Guest Libraries S Turega, W Cullen, M Whitehead, CA Hunter, MD Ward – Journal of the American Chemical Society (2014) 136, 8475 (DOI: 10.1021/ja504269m) Measurement of supramolecular effective molarities for intramolecular H-bonds in zinc porphyrin-imidazole complexes. MA Jinks, H Sun, CA Hunter – Org Biomol Chem (2014) 12, 1440 (DOI: 10.1039/c3ob42246a) A solvent-resistant halogen bond CC Robertson, RN Perutz, L Brammer, CA Hunter – Chem. Sci. (2014) 5, 4179 (DOI: 10.1039/C4SC01746C) Fac and mer isomers of Ru(II) tris(pyrazolyl-pyridine) complexes as models for the vertices of coordination cages: structural characterisation and hydrogen-bonding characteristics. AJ Metherell, W Cullen, A Stephenson, CA Hunter, MD Ward – Dalton transactions (Cambridge, England : 2003) (2014) 43, 71 (DOI: 10.1039/c3dt52479e) Metal Hydrides Form Halogen Bonds: Measurement of Energetics of Binding DA Smith, L Brammer, CA Hunter, RN Perutz – Journal of the American Chemical Society (2014) 136, 1288 (DOI: 10.1021/ja4121499) Validation of a computational cocrystal prediction tool: Comparison of virtual and experimental cocrystal screening results T Grecu, CA Hunter, EJ Gardiner, JF McCabe – Crystal Growth & Design (2014) 14, 165 (DOI: 10.1021/cg401339v) Virtual Screening Identifies New Cocrystals of Nalidixic Acid T Grecu, H Adams, CA Hunter, JF McCabe, A Portell, R Prohens – Crystal Growth & Design (2014) 14, 1749 (DOI: 10.1021/cg401889h) A surface site interaction model for the properties of liquids at equilibrium CA Hunter – Chemical Science (2013) 4, 1687 (DOI: 10.1039/c3sc22124e) Footprinting molecular electrostatic potential surfaces for calculation of solvation energies CS Calero, J Farwer, EJ Gardiner, CA Hunter, M Mackey, S Scuderi, S Thompson, JG Vinter – Physical chemistry chemical physics : PCCP (2013) 15, 18262 (DOI: 10.1039/c3cp53158a) Interplay of Self-Association and Solvation in Polar Liquids V Amenta, JL Cook, CA Hunter, CM Low, H Sun, JG Vinter – Journal of the American Chemical Society (2013) 135, 12091 (DOI: 10.1021/ja405799q) Quantification of solvent effects on molecular recognition in polyhedral coordination cage hosts M Whitehead, S Turega, A Stephenson, CA Hunter, MD Ward – Chemical Science (2013) 4, 2744 (DOI: 10.1039/c3sc50546d) Quantification of the Effect of Conformational Restriction on Supramolecular Effective Molarities H Adams, E Chekmeneva, CA Hunter, MC Misuraca, C Navarro, SM Turega – Journal of the American Chemical Society (2013) 135, 1853 (DOI: 10.1021/ja310221t) Relationship between chemical structure and supramolecular effective molarity for formation of intramolecular H-bonds. H Sun, CA Hunter, C Navarro, S Turega – Journal of the American Chemical Society (2013) 135, 13129 (DOI: 10.1021/ja406235d) Shape-, size-, and functional group-selective binding of small organic guests in a paramagnetic coordination cage. S Turega, M Whitehead, BR Hall, AJ Meijer, CA Hunter, MD Ward – Inorg Chem (2013) 52, 1122 (DOI: 10.1021/ic302498t) Van der Waals interactions in non-polar liquids CA Hunter – Chemical Science (2013) 4, 834 (DOI: 10.1039/c2sc21666c)