研究领域

Theoretical/Biological

Data is the bedrock of science and the Internet enables elements of data from laboratories around the world to be collected together. New discoveries lie dormant in this ocean of data - but only if we devise the right tools for discovery. "Science is built upon facts, as a house is built of stones; but an accumulation of facts is no more a science that a heap of stones is a house." (Henri Poincare) At the Centre for Molecular Informatics within the Department of Chemistry at Cambridge powerful computers enable us to research in silico novel molecular properties from this data. With our partners around the world, in academia and industry, we are devising new methods of creating, manipulating and describing molecular data and new laboratory experiments to confirm our findings. Browse these pages to see the work of our research groups and the exciting opportunities we offer to PhD students, research fellows and others.

近期论文

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Protein Sectors: Statistical Coupling Analysis versus Conservation. T Teşileanu, LJ Colwell, S Leibler – PLoS Comput Biol (2015) 11, e1004091 (DOI: 10.1371/journal.pcbi.1004091) Feynman-Hellmann Theorem and Signal Identification from Sample Covariance Matrices LJ Colwell, Y Qin, M Huntley, A Manta, MP Brenner – Physical Review X (2014) 4, ARTN 031032 (DOI: 10.1103/PhysRevX.4.031032) Conservation Weighting Functions Enable Covariance Analyses to Detect Functionally Important Amino Acids LJ Colwell, MP Brenner, AW Murray – PLoS One (2014) 9, e107723 (DOI: 10.1371/journal.pone.0107723) Predicting functionally informative mutations in Escherichia coli BamA using evolutionary covariance analysis RS Dwyer, DP Ricci, LJ Colwell, TJ Silhavy, NS Wingreen – Genetics (2013) 195, 443 (DOI: 10.1534/genetics.113.155861) Three-Dimensional Structures of Membrane Proteins from Genomic Sequencing TA Hopf, LJ Colwell, R Sheridan, B Rost, C Sander, DS Marks – Cell (2012) 149, 1607 (DOI: 10.1016/j.cell.2012.04.012) The emergence of protein complexes: Quaternary structure, dynamics and allostery T Perica, JA Marsh, FL Sousa, E Natan, LJ Colwell, SE Ahnert, SA Teichmann – Biochemical Society Transactions (2012) 40, 475 (DOI: 10.1042/bst20120056) The interface of protein structure, protein biophysics, and molecular evolution. DA Liberles, SA Teichmann, I Bahar, U Bastolla, J Bloom, E Bornberg-Bauer, LJ Colwell, AP de Koning, NV Dokholyan, J Echave, A Elofsson, DL Gerloff, RA Goldstein, JA Grahnen, MT Holder, C Lakner, N Lartillot, SC Lovell, G Naylor, T Perica, DD Pollock, T Pupko, L Regan, A Roger, N Rubinstein, E Shakhnovich, K Sjölander, S Sunyaev, AI Teufel, JL Thorne, JW Thornton, DM Weinreich, S Whelan – Protein Science (2012) 21, 769 (DOI: 10.1002/pro.2071) A core subunit of Polycomb repressive complex 1 is broadly conserved in function but not primary sequence. LY Beh, LJ Colwell, NJ Francis – Proceedings of the National Academy of Sciences of the United States of America (2012) 109, E1063 (DOI: 10.1073/pnas.1118678109) Protein 3D Structure Computed from Evolutionary Sequence Variation DS Marks, LJ Colwell, R Sheridan, TA Hopf, A Pagnani, R Zecchina, C Sander – PLoS One (2011) 6, e28766 (DOI: 10.1371/journal.pone.0028766) 3D Protein Structure Predicted from Sequence DS Marks, LJ Colwell, RP Sheridan, TA Hopf, A Pagnani, R ZecchinaCharge as a Selection Criterion for Translocation through the Nuclear Pore Complex. LJ Colwell, MP Brenner, K Ribbeck – PLoS computational biology (2010) 6, e1000747 (DOI: 10.1371/journal.pcbi.1000747) Action potential initiation in the hodgkin-huxley model. LJ Colwell, MP Brenner – PLoS computational biology (2009) 5, e1000265 (DOI: 10.1371/journal.pcbi.1000265) C Sander – CoRR (2011) abs/1110.5091