研究领域

Biological

Our research programme is at the interfaces of Chemistry and Biology. It aims at developing novel aqueous, chemoselective methods and their use for selective protein/ligand labelling in vitro and in vivo to understand and influence human disease. For further info on our research and for oportunities please check our research group website.

近期论文

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Spontaneous CO Release from Ru-II(CO)(2)-Protein Complexes in Aqueous Solution, Cells, and Mice M Chaves-Ferreira, IS Albuquerque, D Matak-Vinkovic, AC Coelho, SM Carvalho, LM Saraiva, CC Romão, GJ Bernardes – Angew Chem Int Ed Engl (2015) 54, 1172 (DOI: 10.1002/anie.201409344) A contribution to the rational design of Ru(CO) 3 Cl 2 L complexes for in vivo delivery of CO JD Seixas, MFA Santos, A Mukhopadhyay, AC Coelho, PM Reis, LF Veiros, AR Marques, N Penacho, AML Gonçalves, MJ Romão, GJL Bernardes, T Santos-Silva, CC Romão – Dalton Trans. (2015) 44, 5058 (DOI: 10.1039/C4DT02966F) Functionalized protein nanoemulsions by incorporation of chemically modified BSA A Loureiro, AS Abreu, MP Sarria, MCO Figueiredo, LM Saraiva, GJL Bernardes, AC Gomes, A Cavaco-Paulo – RSC Adv. (2015) 5, 4976 (DOI: 10.1039/C4RA13802C) Collagen labelling with an azide-proline chemical reporter in live cells. B Amgarten, R Rajan, N Martínez-Sáez, BL Oliveira, IS Albuquerque, RA Brooks, DG Reid, MJ Duer, GJ Bernardes – Chemical communications (Cambridge, England) (2014) (DOI: 10.1039/c4cc07974d) A small-molecule drug conjugate for the treatment of carbonic anhydrase IX expressing tumors N Krall, F Pretto, W Decurtins, GJL Bernardes, CT Supuran, D Neri – Angewandte Chemie - International Edition (2014) 53, 4231 (DOI: 10.1002/anie.201310709) Carbon-monoxide-releasing molecules for the delivery of therapeutic co in vivo S García-Gallego, GJ Bernardes – Angew Chem Int Ed Engl (2014) 53, 9712 (DOI: 10.1002/anie.201311225) Curative properties of noninternalizing antibody-drug conjugates based on maytansinoids E Perrino, M Steiner, N Krall, GJ Bernardes, F Pretto, G Casi, D Neri – Cancer Res (2014) 74, 2569 (DOI: 10.1158/0008-5472.can-13-2990) Cysteine-selective reactions for antibody conjugation. PM Cal, GJ Bernardes, PM Gois – Angew Chem Int Ed Engl (2014) 53, 10585 (DOI: 10.1002/anie.201405702) Highlights from the 49th EUCHEM Conference on Stereochemistry, Bürgenstock, Switzerland, May 2014 GJ Bernardes, AL Lawrence – Chemical communications (Cambridge, England) (2014) 50, 10752 (DOI: 10.1039/c4cc90250e) Rationally designed short polyisoprenol-linked PglB substrates for engineered polypeptide and protein N-glycosylation F Liu, B Vijayakrishnan, A Faridmoayer, TA Taylor, TB Parsons, GJL Bernardes, M Kowarik, BG Davis – Journal of the American Chemical Society (2014) 136, 566 (DOI: 10.1021/ja409409h) Protein micro- and nano-capsules for biomedical applications U Shimanovich, GJ Bernardes, TP Knowles, A Cavaco-Paulo – Chemical Society reviews (2014) 43, 1361 (DOI: 10.1039/c3cs60376h) Chemoselective transformations for bioimaging and targeted therapeutics GJL Bernardes – EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2013) 42, S55 Highlights from the 48th EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2013 GJ Bernardes – Chemical communications (Cambridge, England) (2013) 49, 8578 (DOI: 10.1039/c3cc90259e) Site-specific chemical modification of antibody fragments using traceless cleavable linkers. GJ Bernardes, M Steiner, I Hartmann, D Neri, G Casi – Nature protocols (2013) 8, 2079 (DOI: 10.1038/nprot.2013.121) Spacer length shapes drug release and therapeutic efficacy of traceless disulfide-linked ADCs targeting the tumor neovasculature M Steiner, I Hartmann, E Perrino, G Casi, S Brighton, I Jelesarov, GJL Bernardes, D Neri – Chemical Science (2013) 4, 297 (DOI: 10.1039/c2sc21107f) Generation of carbon monoxide releasing molecules (CO-RMs) as drug candidates for the treatment of acute liver injury: Targeting of CO-RMs to the liver AR Marques, L Kromer, DJ Gallo, N Penacho, SS Rodrigues, JD Seixas, GJL Bernardes, PM Reis, SL Otterbein, RA Ruggieri, ASG Gonçalves, AML Gonçalves, MND Matos, I Bento, LE Otterbein, WA Blättler, CC Romão – Organometallics (2012) 31, 5810 (DOI: 10.1021/om300360c) Building well-defined glycoproteins GJL Bernardes, BG Davis – ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2012) 243 Chemical site-selective protein modification: Development of a traceless vascular targeting ADC for cancer therapy GJL Bernardes, D Neri, BG Davis – ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2012) 243 Chemical site-selective radiolabelling of proteins using fluorosugars O Boutureira, GJL Bernardes, BG Davis – ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2012) 243 A novel carbon monoxide-releasing molecule fully protects mice from severe malaria. AC Pena, N Penacho, L Mancio-Silva, R Neres, JD Seixas, AC Fernandes, CC Romão, MM Mota, GJ Bernardes, A Pamplona – Antimicrobial agents and chemotherapy (2012) 56, 1281 (DOI: 10.1128/AAC.05571-11)