Leigh, David - The University of Manchester

个人简介

B.Sc. (1984); Ph. D. (1987) University of Sheffield 1987-89 Postdoctoral Research Associate, National Research Council of Canada (Ottawa) 1989-95 Lecturer in Organic Chemistry, University of Manchester Institute of Science and Technology 1996-98 Reader in Organic Chemistry, University of Manchester Institute of Science and Technology 1998-2001 Chair of Synthetic Chemistry, University of Warwick 1998-2003 EPSRC Advanced Research Fellow 2001-12 Forbes Chair of Organic Chemistry, University of Edinburgh 2012-13 Professor of Organic Chemistry, University of Manchester 2014- Sir Samuel Hall Chair of Chemistry, University of Manchester 2003 Royal Society of Chemistry Award for Supramolecular Chemistry 2004 Fellow of the Royal Society of Chemistry 2004 Royal Society of Chemistry Interdisciplinary Award 2005 Institute of Chemistry of Ireland Award for Chemistry 2005 Swiss Chemical Society Troisième Conferencier in Chemistry 2005 Elected Fellow of the Royal Society of Edinburgh, Scotland’s National Academy of Science & Letters 2005 Royal Society-Wolfson Research Merit Award 2005-10 EPSRC Senior Research Fellow 2005 Royal Society of Chemistry Award for Nanotechnology 2007 International Izatt-Christensen Award in Macrocyclic Chemistry 2007 Royal Society of Chemistry-Real Sociedad Española de Química (RSC-RSEQ) Prize for Chemistry 2007 Chancellor's Award for Research 2007 Feynman Prize for Nanotechnology 2007 Descartes Prize for Research 2008 ERC Advanced Grant (inaugural call) 2009 Elected Fellow of the Royal Society (London), the National Academy of Science of the UK and the Commonwealth 2009 Royal Society of Chemistry Merck Award 2010 Royal Society of Chemistry Tilden Prize 2013 Royal Society Bakerian Lecture 2014 Royal Society of Chemistry Pedler Award 2015 Elected to the Academia Europaea, the European Academy of Science, Humanities & Letters 2016-26 Royal Society Research Professor 2017 Royal Society of Chemistry Perkin Prize for Organic Chemistry 2018 ERC Advanced Grant 2018 Distinguished Professor, East China Normal University 2018 Clarivate Analytics (formerly Thomson Reuters) Web of Science Highly-Cited Researcher 2019 ISNSCE (International Society for Nanoscale Science, Computation and Engineering) Nanoscience Prize 2019 Honorary Membership of the Israel Chemical Society 2020 Academic Influence ’Top Influential Chemists 2010-2020’ 2021 Royal Medal, Royal Society of Edinburgh 2023 Royal Society of Chemistry Horizon Prize: Perkin Prize in Physical Organic Chemistry

研究领域

Our group explores, invents and discovers fundamental ways to control molecular-level dynamics and topology. This includes strategies and methods to synthesize interlocked molecular architectures (e.g. benzylic amide and metal ‘passive template’ catenanes, rotaxanes and molecular shuttles and catalytic ‘active template’ synthesis), molecular machinery , molecular ratchet mechanisms , molecular knotting, molecular assemblers , molecular robotics and molecular weaving .

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

‘Mechanical scission of a knotted polymer’, M Zhang, R Nixon, F Schaufelberger, L Pirvu, G De Bo and D A Leigh, Nat Chem, published online 22 April 2024. ‘Macroscopic spiral rotation of microscopic objects induced by nanoscale rotaxane dynamics’, A Ryabchun, R Jamagne, J Echavarren, M Patanapongpibul, L Zhang, N Katsonis and D A Leigh, Chem, published online 11 April 2024. ‘Molecular ratchets and kinetic asymmetry: Giving chemistry direction’, S Borsley, D A Leigh and B M W Roberts, Angew Chem Int Ed, published online 3 April 2024. ‘Endergonic synthesis driven by chemical fuelling’, E Olivieri, J M Gallagher, A Betts, T W Mrad, and D A Leigh, Nat Synth, published online 11 March 2024. ‘Changing liquid crystal helical pitch with a reversible rotaxane switch’, S Chen, N Katsonis, D A Leigh, M Patanapongpibul, A Ryabchun and L Zhang, Angew Chem Int Ed, published online 6 March 2024. ‘Stepwise operation of a molecular rotary motor driven by an Appel reaction’, P Zwick, A Troncossi, S Borsley, I J Vitorica-Yrezabal, and D A Leigh, J Am Chem Soc, 146, 4467-4472 (2024). ‘Ratcheting synthesis’, S Borsley, J M Gallagher, D A Leigh and B M W Roberts, Nat Rev Chem, 8, 8-29 (2024). ‘Non-equilibrium structure and dynamics: Giving chemistry direction’, D A Leigh, Chemistry Challenges of the 21st Century. Proceedings of the 100th Anniversary of International Solvay Conferences on Chemistry, Ed. K. Wüthrich, B. L. Feringa, L. Rongy and A. De Wit, pp 111-115 (2024). ‘Conformational selection accelerates catalysis by an organocatalytic molecular motor’, J M Gallagher, B M W Roberts, S Borsley and D A Leigh, Chem, 10, 855-866 (2024). ‘Switched “on” transient fluorescence output from a pulsed-fuel molecular ratchet’, A S Baluna, M Dommaschk, B Groh, S Kassem, D A Leigh, D J Tetlow, D Thomas and L V López, J Am Chem Soc, 145, 27113-27119 (2023). ‘The role of kinetic asymmetry and power strokes in an information ratchet’, L Binks, S Borsley, T R Gingrich, D A Leigh, E Penocchio, and B M W Roberts, Chem, published online 19 June 2023. ‘Single-molecule studies on artificial small-molecule machines’, Z-H Zhang, H-N Feng, G Chi, D A Leigh and L Zhang, CCS Chem, published online 17 May 2023. ‘In search of Wasserman’s catenane’, A S Baluna, A Galan, D A Leigh, G D Smith, J T J Spence, D J Tetlow, I J Vitorica-Yrezabal and M Zhang, J Am Chem Soc, 145, 9825-9833 (2023). ‘Compact rotaxane superbases’, M J Power, D T J Morris, I J Vitorica-Yrezabal and D A Leigh, J Am Chem Soc, 145, 8593-8599 (2023). 'Mechanical tightening of a synthetic molecular knot', M Calvaresi, A-S Duwez, D A Leigh, D Sluysmans, Y Song, F Zerbetto and L Zhang, Chem, 9, 65-75 (2023). [Featured on the cover of Chem]. 'Using catalysis to drive chemistry away from equilibrium: relating kinetic asymmetry, power strokes, and the Curtin-Hammett principle in Brownian ratchets', S Amano, M Esposito, E Kreidt, D A Leigh, E Penocchio and B M W Roberts, J Am Chem Soc, 144, 20153-20164 (2022). 'A tape-reading molecular ratchet', Y Ren, R Jamagne, D J Tetlow and D A Leigh, Nature, 612, 78–82 (2022). 'Tuning the force, speed, and efficiency of an autonomous chemically fuelled information ratchet', S Borsley, D A Leigh, B M W Roberts and I J Vitorica-Yrezabal, J Am Chem Soc, 144, 17241-17248 (2022). 'Social self-sorting synthesis of molecular knots', Z Ashbridge, O M Knapp, E Kreidt, D A Leigh, L Pirvu and F Schaufelberger, J Am Chem Soc, 144, 17232-17240 (2022). 'Transamidation-driven molecular pumps', L Binks, C Tian, S D P Fielden, I J Vitorica-Yrezabal and D A Leigh, J Am Chem Soc, 144, 15838-15844 (2022). 'Knotting matters: orderly molecular entanglements', Z Ashbridge, S D P Fielden, D A Leigh, L Pirvu, F Schaufelberger and L Zhang, Chem Soc Rev, 51, 7779-7809 (2022). [Featured on the cover of Chem Soc Rev]. 'Chemical fuels for molecular machinery', S Borsley, D A Leigh and B M W Roberts, Nat Chem, 14, 728-738 (2022). 'Decorating polymer beads with 1014 inorganic-organic [2]rotaxanes as shown by spin counting', D Asthana, D Thomas, S J Lockyer, A Brookfield, G A Timco, I J Vitorica-Yrezabal, G F S Whitehead, E J L McInnes, D Collison, D A Leigh and R E P Winpenny, Commun Chem, 5, 73 (2022). ‘Foreword', D A Leigh, pp. XIV-XV, in 'Women in Supramolecular Chemistry: Collectively Crafting the Rhythms of Our Work and Lives in STEM', J Leigh, J Hiscock, A McConnell, C Haynes, C Caltagirone, M Kieffer, E Draper, A Slater, L K S von Krbek, K Hutchins, D Watkins and N Busschaert, Policy Press, Bristol, UK (2022). 'Autonomous fuelled directional rotation about a covalent single bond', S Borsley, E Kreidt, D A Leigh and B M W Roberts, Nature, 604, 80–85 (2022). 'Pumping between phases with a pulsed-fuel molecular ratchet', D Thomas, D J Tetlow, Y Ren, S Kassem, U Karaca and D A Leigh, Nat Nanotechnol, 17, 701–707 (2022). 'Insights from an information thermodynamics analysis of a synthetic molecular motor', S Amano, M Esposito, E Kreidt, D A Leigh, E Penocchio and B M W Roberts, Nat Chem, 14, 530-537 (2022). 'Vernier template synthesis of molecular knots', Z Ashbridge, E Kreidt, L Pirvu, F Schaufelberger, J Halldin Stenlid, F Abild-Pedersen and D A Leigh, Science, 375, 1035-1041 (2022). 'Molecular weaving', Z-H Zhang, B J Andreassen, D P August, D A Leigh and L Zhang, Nat Mater, 21, 275-283 (2022). [Featured on the cover of Nat. Mater.]. 'Real-time observation of the dynamics of an individual rotaxane molecular shuttle using a single molecule junction', S Chen, D Su, C Jia, Y Li, X Li, X Guo, D A Leigh and L Zhang, Chem, 8, 243-252 (2022). 'Chemical engines: Driving systems away from equilibrium through catalyst reaction cycles', S Amano, S Borsley, D A Leigh and Z Sun, Nat Nanotechnol, 16, 1057-1067 (2021). 'A catalysis-driven artificial molecular pump', S Amano, S D P Fielden and D A Leigh, Nature, 594, 529-534 (2021). 'Sequence-selective decapeptide synthesis by the parallel operation of two artificial molecular machines', J Echavarren, M A Y Gall, A Haertsch, D A Leigh, J T J Spence, D J Tetlow and C Tian, J Am Chem Soc, 143, 5158-5165 (2021). 'A doubly kinetically-gated information ratchet autonomously driven by carbodiimide hydration', S Borsley, D A Leigh and B M W Roberts, J Am Chem Soc, 143, 4414-4420 (2021). 'Site-to-site peptide transport on a molecular platform using a small-molecule robotic arm', S Kassem, A T L Lee, D A Leigh, A Markevicius, D J Tetlow and N Toriumi, Chem Sci, 12, 2065-2070 (2021). 'Effects of turn-structure on folding and entanglement in artificial molecular overhand knots', Y Song, F Schaufelberger, Z Ashbridge, L Pirvu, I J Vitorica-Yrezabal and D A Leigh, Chem Sci, 12, 1826-1833 (2021). 'Real-time fluctuations in single-molecule rotaxane experiments reveal an intermediate weak binding state during shuttling', D Sluysmans, P Lussis, C-A Fustin, A Bertocco, D A Leigh and A-S Duwez, J Am Chem Soc, 143, 2348-2352 (2021). 'A chiral cyclometalated Iridium Star of David [2]catenane', D P August, J Jaramillo-Garcia, D A Leigh, A Valero and I J Vitorica-Yrezabal, J Am Chem Soc, 143, 1154-1161 (2021). 'A molecular endless (74) knot', D A Leigh, J J Danon, S D P Fielden, J-F Lemonnier, G F S Whitehead and S L Woltering, Nat Chem, 13, 117-122 (2021). [Featured on the cover of Nat Chem.; Behind-the-paper blogpost: 'Knots - an endless challenge', D A Leigh] 'Self-assembly of a layered two-dimensional molecularly woven fabric', D P August, R A W Dryfe, S J Haigh, P R C Kent, D A Leigh, J-F Lemonnier, Z Li, C A Muryn, L I Palmer, Y Song, G F S Whitehead and R J Young, Nature, 588, 429-435 (2020). How it works. 'Transmembrane ion channels formed by a Star of David [2]catenane and a molecular pentafoil knot', D P August, S Borsley, S L Cockroft, F della Sala, D A Leigh and S J Webb, J Am Chem Soc, 142, 18859-18865 (2020). 'A track-based molecular synthesizer that builds a single-sequence oligomer through iterative carbon-carbon bond formation', C T McTernan, G De Bo and D A Leigh, Chem, 6, 2964-2973 (2020). Featured on the cover of Chem (image credit: Jo Richers; www.jorichers.com). ‘Tying different knots in a molecular strand’, D A Leigh, F Schaufelberger, L Pirvu, J Halldin Stenlid, D P August and J Segard, Nature, 584, 562-568 (2020). 'Knotting a molecular strand can invert macroscopic effects of chirality', N Katsonis, F Lancia, D A Leigh, L Pirvu, A Ryabchun and F Schaufelberger, Nat. Chem., 12, 939-944 (2020). [Behind-the-paper blogpost: 'Knotting to see here', F Schaufelberger] 'Single-step enantioselective synthesis of mechanically planar chiral [2]rotaxanes using a chiral leaving group strategy', C Tian, S D P Fielden, B Pérez-Saavedra, I J Vitorica-Yrezabal and D A Leigh, J Am Chem Soc, 142, 9803-9808 (2020). 'Weak functional group interactions revealed through metal-free active template rotaxane synthesis', C Tian, S D P Fielden, G F S Whitehead, I J Vitorica-Yrezabal and D A Leigh, Nat Commun, 11, 744 (2020).: Featured in Nat Commun Focus: Nanoscale & Supramolecular Chemistry, 6 Feb 2020. 'Dynamic control of chiral space through local symmetry breaking in a rotaxane organocatalyst', M Dommaschk, J Echavarren, D A Leigh, V Marcos and T A Singleton, Angew Chem Int Ed, 58, 14955-14958 (2019). ‘Self-sorting assembly of molecular trefoil knots of single handedness’, J Zhong, L Zhang, D August, G F S Whitehead and D A Leigh, J Am Chem Soc, 141, 14249-14256 (2019). ‘Active template rotaxane synthesis through the Ni-catalyzed cross-coupling of alkylzinc reagents with redox-active esters’, J Echavarren, M A Y Gall, A Haertsch, D A Leigh, V Marcos and D J Tetlow, Chem Sci, 10, 7269-7273 (2019). ‘Dissipative catalysis with a molecular machine’, C Biagini, S D P Fielden, D A Leigh, F Schaufelberger, S Di Stefano and D Thomas, Angew Chem Int Ed, 58, 9876-9880 (2019). [Hot Paper] Featured on the cover of Angew Chem Int Ed (image credit: Dr. Anna Tanczos, SciComm Studios). ‘Stereoselective synthesis of molecular square and granny knots’, D A Leigh, L Pirvu and F Schaufelberger, J Am Chem Soc, 141, 6054-6059 (2019). ‘Coordination chemistry of a molecular pentafoil knot’, L Zhang, A J Stephens, J-F Lemonnier, L Pirvu, I J Vitorica-Yrezabal, C J Robinson and D A Leigh, J Am Chem Soc, 141, 3952-3958 (2019). ‘Probing the dynamics of imine-based pentafoil knot and pentameric circular helicate assembly’, J-F Ayme, J E Beves, C J Campbell and D A Leigh, J Am Chem Soc, 141, 3605-3612 (2019). ‘Effects of knot tightness at the molecular level’, L Zhang, J-F Lemonnier, A Acocella, M Calvaresi, F Zerbetto and D A Leigh, Proc Natl Acad Sci USA, 116, 2452-2457 (2019). ‘Analysis of two [2]catenanes based on electron densities from invariom refinement and results from DFT calculations’, P Luger, B Dittrich, S Mebs, A M Z Slawin and D A Leigh, Z. Naturforsch., 73b, 677-687 (2018). ‘Stereoselective synthesis of a composite knot with nine crossings’, L Zhang, A J Stephens, A L Nussbaumer, J-F Lemonnier, P Jurček, I J Vitorica-Yrezabal and D A Leigh, Nature Chem, 10, 1083-1088 (2018). Featured on the cover of Nat Chem. ‘A six-crossing doubly interlocked [2]catenane with twisted rings, and a molecular granny knot’, J J Danon, D A Leigh, S Pisano, A Valero and I J Vitorica-Yrezabal, Angew Chem Int Ed, 57, 13833-13837 (2018). ‘Comment on “Coordination-Driven Self-Assembly of a Molecular Knot Comprising Sixteen Crossings"’, D A Leigh, J-F Lemonnier and S L Woltering, Angew Chem Int Ed, 57, 12212-12214 (2018). ‘Spontaneous assembly of rotaxanes from a primary amine, crown ether and electrophile’, S D P Fielden, D A Leigh, C T McTernan, B Pérez-Saavedra and I J Vitorica-Yrezabal, J Am Chem Soc, 140, 6049-6052 (2018). ‘Securing a supramolecular architecture by tying a stopper knot’, D A Leigh, L Pirvu, F Schaufelberger, D J Tetlow and L Zhang, Angew Chem Int Ed, 57, 10484-10488 (2018). [VIP paper] Featured as the Frontispiece (image credit: Jo Richers; www.jorichers.com). ‘An artificial molecular machine that builds an asymmetric catalyst’, G De Bo, M A Y Gall, S Kuschel, J De Winter, P Gerbaux and D A Leigh, Nature Nanotech, 13, 381-385 (2018). ‘A molecular trefoil knot from a trimeric circular helicate’, L Zhang, D P August, J Zhong, G F S Whitehead, I J Vitorica-Yrezabal and D A Leigh, J Am Chem Soc, 140, 4982-4985 (2018). ‘Molecular machines with bio-inspired mechanisms’, L Zhang, V Marcos and D A Leigh, Proc Natl Acad Sci USA, 115, 9397-9404 (2018).