研究领域

Organic Chemistry and Biochemistry

Professor Lang (b. 1979) conducts research in the interdisciplinary area of chemical biology, applying concepts from organic chemistry to develop new tools to study fundamental biological questions. Her research focuses on the targeted chemical synthesis of new artificial biomolecules (amino acids, proteins, nucleotides, oligonucleotides) tailored to investigate and manipulate complex cellular processes in in vitro and in vivo biological systems.

近期论文

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K. Wang, A. Sachdeva, D.J. Cox, N.W. Wilf, K. Lang, S. Wallace, R.A. Mehl and J.W. Chin* Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double labelling and FRET Nature Chemistry 2014, 6, 393. T.S Elliott, F.M. Townsley, A. Bianco, R.J. Ernst, A. Sachdeva, S.J. Elsässer, L. Davis, K. Lang, R. Pisa, S. Greiss, K.S. Lilley and J.W. Chin* Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal Nature Biotechnology 2014, 32, 465. K. Lang*, J.W. Chin* Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins Chemical Reviews 2014, 114, 4764. D. Perez-Fernandez, D. Shcherbakov, T. Matt, N.C. Leong, I. Kudyba, S. Duscha, H. Boukari, R. Patak, S.R. Dubbaka, K. Lang, M. Meyer, R. Akbergenov, P. Freihofer, S. Vaddi, P. Thommes, V. Ramakrishnan, A. Vasella, E.C. Böttger 4'-O-substitutions determine selectivity of aminoglycoside antibiotics Nature Communications 2014, 5:3112, doi: 10.1038/ncomms4112. K. Lang*, J.W. Chin* Bioorthogonal reactions for labeling proteins ACS Chemical Biology 2014, 9, 16. K. Lang*, J.W. Chin* Fluorescence imaging: shining a light into live cells Nature Chemistry 2013, 5, 81. A. Bianco, F. Townsley, S. Greiss, K. Lang, and J.W. Chin* Expanding the genetic code of drosophila melanogaster Nature Chem. Biol. 2012, 8, 748. T. Matt1, C.L. Ng1, K. Lang1, S.H. Sha1, R. Akbergenov1, D. Shcherbakov1, M. Meyer, S. Duscha, J. Xie, S.R. Dubbaka, D. Perez-Fernandez, A. Vasella, V. Ramakrishnan, J. Schacht, E.C. Böttger* Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin PNAS 2012, 109, 10984. K. Lang, L. Davis, S. Wallace, M. Mahesh, D.J. Cox, M.L. Blackman, J.M. Fox, J.W. Chin* Genetic encoding of bicyclononynes and trans-cyclooctenes for site-specific protein labeling in vitro and in live mammalian cells via rapid fluorogenic Diels-Alder reactions Journal Am. Chem. Soc. 2012, 134, 10317. K. Lang1, L. Davis1, J. Torres-Kolbus, C. Chou, A. Deiters*, J.W. Chin* Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction Nature Chemistry 2012, 5, 298.