个人简介
Dr Yan received his BSc (in biological sciences) at Tsinghua University and PhD (in Medical Science) at Karolinska Institutet, investigating molecular mechanism of transcriptional regulation in colorectal cancer cells (supervisor: Prof. Jussi Taipale). In 2014, Dr Yan moved to US to study 3D genome organization and gene regulation as a postdoc fellow at UC San Diego (with Prof. Bing Ren). After more than a decade of biological research training in Asia, Europe and America, he joined the Department of Biomedical Sciences, in the fall of 2018, focusing on function of human genomic sequences in complex human diseases by developing state-of-the-art tools.
研究领域
Due to high mutation burden in regulatory elements, affected cells develop aberrant gene transcription compared with surrounding normal cells that could device them with growth advantage. Some transcripts (including non-coding RNAs) have been used as clinical diagnostic markers for some cancer types whereas the molecular mechanism of their relevance to the cancer development remains largely elusive. Our research goal is to unveil molecular mechanism of how transcriptional aberration affects cancer development, using high throughput, state-of-the-art tools. My current interest focuses on developing genomic tools to:
Dissect of lncRNA function and mechanism in disease
Identify of genetic variations that contribute to disease pathogenesis
Study protein-chromatin binding with extremely low number of cells and apply it to study cell heterogeneity
近期论文
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Yi W, Li J, Zhu X, Wang X, Fan L, Sun W, Liao L, Zhang J, Li X, Ye J, Chen F, Taipale J, Chan KM, Zhang L, Yan J, CRISPR-Assisted Detection of RNA-Protein Interactions in Living Cells, Nature Methods (2020) (https://doi.org/10.1038/s41592-020-0866-0).
Wang X, Cairns MJ, Yan J, Super-enhancers in transcriptional regulation and genome organization, Nucleic Acids Research 47(22) (2019) 11481-11496.
Greenwald WW*, Chiou J*, Yan J*, Qiu Y*, Dai N*, Wang A, Nariai N, Aylward A, Han JY, Kadakia N, Regue L, Okino ML, Drees F, Kramer D, Vinckier N, Minichiello L, Gorkin D, Avruch J, Frazer K, Sander MA, Ren B, Gaulton KJ. Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk. Nature Communications. 2019 May 7; 10:2078
Yan J, Chen SA, Local A, Liu T, Qiu Y, Dorighi KM, Preissl S, Rivera CM, Wang C, Ye Z, Ge K, Hu M, Wysocka J, Ren B. Histone H3 lysine 4 monomethylation modulates long-range chromatin interactions at enhancers. Cell Research. 2018 Feb; 28(2):204-220.
Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science. 2017 May 5; 356(6337).
Yan J, Enge M, Whitington T, Dave K, Liu J, Sur I, Schmierer B, Jolma A, Kivioja T, Taipale M, Taipale J. Transcription Factor Binding in Human Cells Occurs in Dense Clusters Formed around Cohesin Anchor Sites. Cell. 2013 Aug 15; 154(4): 801-13.
Jolma A*, Yan J*, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, et al. DNA-binding specificities of human transcription factors. Cell. 2013 Jan 17; 152(1-2): 327-39.
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