个人简介

Aaron Beeler received his Ph.D. in 2002 from Professor John Rimoldi’s laboratory in the Department of Medicinal Chemistry at the University of Mississippi. He then joined the Porco group as a postodoctoral fellow and subsequently the Center for Chemical Methodology and Library Development at Boston University, now the Center for Molecular Discovery. He was promoted to Assistant Director of the CMLD-BU in January 2005. In 2012 Aaron joined the Department of Chemistry as a tenure-track professor in medicinal chemistry.

研究领域

Synthetic Organic Chemistry

The Beeler Research Group is truly multidisciplinary, combining organic chemistry, engineering, and biology to solve problems in medicinal chemistry. All of these elements are combined and directed toward significant problems in human health. The Beeler Group is addressing focused disease areas (e.g., schizophrenia, Parkinson’s, cystic fibrosis), as well as project areas with broader impact potential (e.g., new methods for discovery of small molecules with anti-cancer properties). Medicinal Chemistry: The goals of medicinal chemistry projects are to optimize small molecules in order to: a) develop a probe that may be utilized as a tool in biological studies; b) develop a lead molecule to facilitate future therapeutics; and c) utilize small molecules to enhance understanding of biological targets that are important for human health. These projects provide students with training in organic chemistry, medicinal chemistry, and focused biology. Projects are selected based on their chemistry and/or biology significance and potential for addressing challenging questions. Technology: One of the core components of the research in the Beeler Group is development of technologies and paradigms that facilitate rapid modification of complex scaffolds. These technologies enable optimization of biologically active lead compounds and identification of small molecule leads in biological systems. The projects focus on utilizing automation, miniaturization, and microfluidics to carry out chemical transformations. These projects are highly interdisciplinary with both chemistry and engineering components. Photochemistry: This area focuses on photochemical transformations toward the synthesis of natural products, natural product scaffolds, and other complex chemotypes of interest to medicinal chemistry and chemical biology. The foundation of these projects is utilizing microfluidics to enable photochemical reaction development.

近期论文

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"Bis-Thiourea Catalyzed Photochemical [2+2]-Cycloaddition of Cinnamates" Telmesani, R.; Park, S. H.; Lynch-Colemata, T.; Beeler, A. B. In preparation. "Discovery and Development of a Potent and Selective HDAC8 Inhibitor" Ingham, O. J.; Paranal, R.; Smith, B.; Snyder, T.; Porco, J. A.; Bradner, J. E.; Beeler, A. B. ACS Med. Chem. Lett. 2014, In preparation. "Development of a Photolabile Amine Protecting Group Suitable for Multistep Flow Synthesis" Yueh, H.; Voevodin, A.; Beeler, A. B. J. Flow Chem. 2014, In Press "Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes" Martin, M. I.; Goodell, J. R.; Ingham, O. J.; Porco, J. A.; Beeler. A. B. J. Org. Chem. 2014, 79, 3838-3846. Publications through 2012 "Synthesis of azaphilone-based chemical libraries, Achard, M.; Beeler, A.; Porco, J., ACS Comb. Sci. 2012, 14, 236-280. "Synthesis and Reactivity of Bicyclo[3.2.1]Octanoid-Derived Cyclopropanes," Goodell, J. R.; Poole, J. L.; Beeler, A. B.; Aubé, J.; Porco, J. A. Jr. J. Org. Chem. 2011, 76, 9792. "Development of a Photochemical Microfluidics Platform," Pimparkar, K.; Yen, B.; Goodell, J. R.; Martin, V. I.; Lee, W-H.; Porco, J. A. Jr.; Beeler, A. B. Jensen, K. F. J. Flow Chem. 2011, 2, 53. "Remodelling of the Natural Product Fumagillol Employing a Reaction Discovery Approach," Balthaser, B. R.; Maloney, M. C.; Beeler, A. B.; Porco, J. A. Jr.; Snyder, J. K. Nature Chem. 2011, 3, 969. "Truncated Aspidosperma Alkaloid-like Scaffolds: Unique Structures For the Discovery of New, Bioactive Compounds," Benson, S. C.; Lee, L.; Wei, W.; Ni, F.; David, J.; Olmos, J.; Strom, K. R.; Beeler, A. B.; Cheng, K. C-C.; Inglese, J.; Kota, S.; Takahashi, V.; Strosberg, A. D.; Connor, J. H.; Bushkin, G. G.; Snyder, J. K. Heterocycles, 2011, 84, 135. "Discovery of New Antimalarial Chemotypes Through Chemical Methodology and Library Development," Brown, L. E.; Cheng, K, C-C; Wei, W-G.; Yuana, P.; Dai, P.; Trilles, R.; Ni, F.; Yuan, J.; MacArthur, R.; Guhab, R.; Johnson, R. L.; Suc, X-Z; Dominguez, M. M.; Snyder, J. K.; Beeler, A. B.; Schaus, S. E.; Inglese, J.; Porco, J. A. Jr. Proc. Nat. Aca. Sci. 2011, 108, 6775. "Catalytic Enantioselective Alkylative Dearomatization−Annulation: Total Synthesis and Absolute Configuration Assignment of Hyperibone K," Qi, J.; Beeler, A. B.; Zhang, Q.; Porco, J. A. Jr. J. Am. Chem. Soc. 2011, 132, 13642. "Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones," Goodell, J. R.; Leng, B.; Snyder, T. K.; Beeler, A. B.; Porco, J. A. Jr. Synthesis, 2010, 2254. "Tandem Processes Identified from Reaction Screening: Nucleophilic Addition to Aryl N-Phosphinylimines Employing La(III)-TFAA Activation," Kinoshita, H.; Ingham, Oscar, J.; Ong, W. W.; Beeler, A. B.; Porco, J. A., Jr. J. Am. Chem. Soc. 2010, 132, 6412. "A Time-Resolved Fluorescence–Resonance Energy Transfer Assay for Identifying Inhibitors of Hepatitis C Virus Core Dimerization," Kota, S.; Scampavia, L.; Spicer, T.; Beeler, A. B.; Takahashi, V.; Snyder, J. K.; Porco, J. A., Jr.; Hodder, P.; Strosberg, A. D. Assay Drug Dev. 2010, 8, 96. "Development of an Automated Microfluidic Reaction Platform for Multidimensional Screening: Reaction Discovery Employing Bicyclo[3.2.1]octanoid Scaffolds." Goodell J. R.; McMullen, J. P; Zaborenko, N.; Maloney, J. R.; C-X Ho; Jensen, K. F.; Porco, J. A. Jr.; Beeler, A. B. J. Org. Chem. 2009, 74, 6169. "Reaction Discovery Employing Macrocycles: Transannular Cyclizations of Macrocyclic Bis-lactams," Han, C.; Rangarajan, S.; Voukides, A. C.; Beeler, A. B.; Johnson, R.; Porco, J. A., Jr. Org. Lett., 2009, 11, 413–416. "Library Synthesis Using 5,6,7,8-Tetrahydro-1,6-naphthyridines as Scaffolds," Zhou, Y.; Beeler, A. B.; Cho, S.; Wang, Y.; Franzblau, S. G.; Snyder, J. K. J. Comb. Chem. 2008, 10, 534–540. "Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen," Peng, L. F.; Kim, S. S.; Matchacheep, S.; Lei, X.; Su, S.; Lin, W.; Runguphan, W.; Choe, W-H; Sakamoto, N.; Ikeda, M.; Kato, N.; Beeler, A. B.; Porco, J. A. Jr.; Schreiber, S. L.; Chung, R. T. Antimicrobi. Agents Chemo. 2007, 10, 3756. "Nucleophilic addition to N-phosphinylimines by rare-earth-metal triflate/trifluoroacetic anhydride activation," Winnie W. Ong; Aaron B. Beeler; Sarathy, Kesavan; James S. Panek; John A. Porco Angew. Chem. Int. Ed. 2007, 39, 7470. "1,2,3,4-Tetrahydro-1,5-naphthyridines and related heterocyclic scaffolds: exploration of suitable chemistry for library development,"Grace H. C. Woo; Aaron B. Beeler; John K. Snyder Tetrahedron 2007, 63, 5649.