个人简介

B.S., Rutgers University; Ph.D., Yale University; Postdoctoral research, University of California at San Diego

研究领域

Biophysical chemistry of proteins and nucleic acids: structure/sequence/and site selectivity in DNA-drug interactions/protein folding/model helix and beta sheet structures

Biophysical chemistry of proteins and nucleic acids: structure, sequence, and site selectivity in DNA-drug interactions, protein folding, model helix and beta sheet structures Our research focuses on the biophysical chemistry and functional properties of proteins and nucleic acids. The problems we are interested in include the stability and structure of DNA, the structure of unfolded proteins and peptide models of these, the determinants of alpha helical stability, and design of new structures and functional agents using peptides. Techniques that we use in our research include NMR spectroscopy and structural analysis, chemical synthesis, kinetic and equilibrium optical, fluorescence and CD spectroscopy, and thermodynamics.

近期论文

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Chapman R, Kulp Iii JL, Patgiri A, Kallenbach NR, Bracken C, Arora PS. Trapping a Folding Intermediate of the alpha-Helix: Stabilization of the pi-Helix. Biochemistry. 2008 Mar 13. [ABSTRACT] Zhou C, Min J, Liu Z, Young A, Deshazer H, Gao T, Chang YT, Kallenbach NR. Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1308-11. [ABSTRACT] Liu J, Zheng Q, Deng Y, Li Q, Kallenbach NR, Lu M. Conformational specificity of the lac repressor coiled-coil tetramerization domain. Biochemistry. 2007 Dec 25;46(51):14951-9 [ABSTRACT] Chen K, Liu Z, Zhou C, Bracken WC, Kallenbach NR. Spin relaxation enhancement confirms dominance of extended conformations in short alanine peptides. Angew Chem Int Ed Engl. 2007;46(47):9036-9 Liu Z, Young AW, Hu P, Rice AJ, Zhou C, Zhang Y, Kallenbach NR. Tuning the membrane selectivity of antimicrobial peptides by using multivalent design. Chembiochem. 2007 Nov 23;8(17):2063-5 Deng Y, Zheng Q, Liu J, Cheng CS, Kallenbach NR, Lu M.Self-assembly of coiled-coil tetramers in the 1.40 A structure of a leucine-zipper mutant. Protein Sci. 2007 Feb;16(2):323-8 [ABSTRACT] Liu J, Deng Y, Zheng Q, Cheng CS, Kallenbach NR, Lu M. A parallel coiled-coil tetramer with offset helices. Biochemistry. 2006 Dec 26;45(51):15224-31 [ABSTRACT] Liu Z, Brady A, Young A, Rasimick B, Chen K, Zhou C, Kallenbach NR. Length effects in antimicrobial peptides of the (RW)n series. Antimicrob Agents Chemother. 2007 Feb;51(2):597-603 [ABSTRACT] Liu J, Zheng Q, Deng Y, Cheng CS, Kallenbach NR, Lu M: A seven-helix coiled coil. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15457-62 [ABSTRACT] Liu Z, Deshazer H, Rice A, Chen K, Zhou C, Kallenbach N: Multivalent antimicrobial peptides from a reactive polymer scaffold. J. Med. Chem. 2006, 49:3436-3439 [ABSTRACT] Shi Z, Chen K, Liu Z, Kallenbach N: Conformation of the backbone in unfolded proteins. Chem. Rev. 2006, 106:1877-1897 [ABSTRACT] Deng Y, Liu J, Zheng Q, Eliezer D, Kallenbach N, Lu M: PII Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat. Structure 2006, 14:247-255. [ABSTRACT] Shi Z, Chen K, Liu Z, Sosnick T, Kallenbach N: PII structure in the model peptides for unfolded proteins: Studies on ubiquitin fragments and several alanine-rich peptides containing QQQ, SSS, FFF, and VVV. Proteins 2006, 62:312-321. [ABSTRACT] Shi Z, Chen K, Liu Z, Ng, A, Bracken C, Kallenbach N: Polyproline II propensities from GGXGG peptides reveal an anticorrelation with beta-sheet scales. Proc. Natl. Acad. Sci. USA 2005, 102:17964-17968. [ABSTRACT] Lee-Huang S, Maiorov V, Huang P, Ng A, Lee H, Chang Y, Kallenbach N, Huang P, Chen H: Structural and functional modeling of human lysozyme reveals a unique nonapeptide, HL9, with anti-HIV activity. Biochemistry 2005, 44:4648-4655. [ABSTRACT] Chen K, Liu Z, Zhou C, Shi Z, Kallenbach N: Neighbor Effect on PPII Conformation in Alanine Peptides. J. Am. Chem. Soc. 2004, 127:10146-10147. [ABSTRACT] McColl I, Blanch E, Hecht L, Kallenbach N, Barron L: Vibrational Raman optical activity characterization of poly(L-proline) II helix in alanine oligopeptides. J. Am. Chem. Soc. 2004, 126:5076-5077. [ABSTRACT] Liu Z, Chen K, Ng A, Shi Z, Woody R, Kallenbach N: Solvent dependence of PII conformation in model alanine peptides. J. Am. Chem. Soc. 2004, 126:15141-15150. [ABSTRACT] Liu J, Yong W, Deng Y, Kallenbach N, Lu M: Atomic structure of a tryptophan-zipper pentamer. Proc. Natl. Acad. Sci. USA 2004, 101:16156-16161. [ABSTRACT] Lee-Huang S, Huang P, Maiorov V, Huang P, Ng A, Chang Y, Kallenbach N, Chen H: Structure function mapping of anti-HIV activity of human lysozyme. FASEB J. 2004, 18:C149-C149.