个人简介

Education B.S. in Chemistry (summa cum laude), Universidad Simon Bolivar, Caracas, Venezuela - Research with Prof. Roberto Sanchez-Delgado at the Venezuelan Institute for Scientific Research Ph.D. in Chemistry, Columbia University - Ph.D. advisor: Prof. Gerard Parkin Postdoctoral training, Massachusetts Institute of Technology - Supervisor: Prof. Stephen J. Lippard Awards and Honors - Whitehead Fellowship for Junior Faculty in Biomedical and Biological Sciences, 2012 - National Institutes of Health NSRA Ruth Kirschstein Postdoctoral Fellowship, 2009-2011 - Louis Hammett Award to Outstanding Ph.D. Student (Columbia University), 2008 - Edith and Eugene Blout Scholarship, 2005-2006 - Jack Miller Award to Outstanding Teaching Assistant (Columbia University), 2005 - Best Student Award (Universidad Simón Bolívar), 2001

研究领域

Bioinorganic Chemistry, Chemical Biology, Molecular Imaging

Research in Daniela’s group will explore the interface of Inorganic Chemistry and Biology, focusing in the design and application of highly tailored systems for the recognition of metal ions and metalloenzymes, combined with careful manipulation of host-guest chemistry and cooperative effects in the assembly of metal complexes and supramolecular constructs for the selective binding of important molecular targets. Emphasis is placed on exploring new avenues for elucidating the role of the investigated species in disease states and developing new diagnostic and therapeutic tools.

近期论文

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Afzal, M. S.; Pitteloud, J.-P.; Buccella, D. “Enhanced Ratiometric Fluorescent Indicators for Magnesium Based on Azoles of the Heavier Chalcogens”. Chem. Commun. 2014, 50, 11358. Schwartz, S. C.;Pinto-Pacheco, B.; Pitteloud, J.-P.; Buccella, D. “Formation of Ternary Complexes with MgATP: Effects on the Detection of Mg2+ in Biological Samples by Bidentate Fluorescent Sensors”. Inorg. Chem. 2014, 53(6), 3204. Lin, W.;Buccella, D.; Lippard, S. J. “Visualization of Peroxynitrite-Induced Changes of Labile Zn2+ in the Endoplasmic Reticulum with Benzoresorufin-based Fluorescent Probes”. J. Am. Chem. Soc. 2013, 135(36), 13512. Apfel, U.-P.; Buccella, D.; Wilson, J. J.; Lippard, S. J. “Detection of Nitric Oxide and Nitroxyl with Benzoresorufin-Based Fluorescent Probes”. Inorg. Chem. 2013, 52(6), 3285. Buccella, D.; Horowitz, J. A.; Lippard, S. J. “Understanding Zinc Quantification with Existing and Advanced Ditopic Fluorescent Zinpyr Sensors”. J. Am. Chem. Soc. 2011, 133(11), 4101. Yurkerwich, K. Buccella, D.; Melnick, J. G.; Parkin, G. “Tris(2-mercapto-1-tert-butylimidazolyl)hydroborato Gallium Derivatives: Synthesis of Di- and Trigallium Compounds in a Sulfur-Rich Coordination Environment” Chem. Sci. 2010, 1(2), 210-214. Egorova, O. A.; Tsay, O. G.; Khatua, S.; Meka, B.; Maiti, N.; Kim, M-K.; Kwon, S. J.; Huh, J. O.; Bucella, D.; Kang, S-O.; Kwak, J.; Churchill, D. G. “Synthetic, Cyclic Voltammetric, Structural, EPR, and UV-Vis Spectroscopic Studies of Thienyl-Containing meso-A2B-cor(CrV=O) Systems: Consideration of Three Interrelated Molecular Detection Modalities” Inorg. Chem. 2010, 49(2), 502-512. Kim, K.; Kim, I.; Maiti, N.; Kwon, S. J.; Bucella, D.; Egorova, O. A.; Lee, Y. S.; Kwak, J.; Churchill, D. G. “A Study of Nerve Agent Model Organophosphonate Binding with Manganese-A2B-corrole and -A2B2-porphyrin Systems” Polyhedron 2009, 28(12), 2418-2430. Shaw, A. P.; Norton, J. R.; Buccella, D.; Sites, L. A.; Kleinbach, S. S.; Jarem, D. A.; Bocage, K. M.; Nataro, C. “Synthesis, Electrochemistry, and Reactivity of Half-Sandwich Ruthenium Complexes Bearing Metallocene-Based Bisphosphines” Organometallics 2009, 28(13), 3804-3814. Carnes, M.; Buccella, D.; Chen, J. Y.-C.; Ramirez, A. P.; Turro, N. J.; Nuckolls, C.; Steigerwald, M. “A Stable Tetraalkyl Complex of Nickel(IV)” Angew. Chem., Intl. Ed. 2009, 48(2), 290-294. Buccella, D.; Parkin, G. “p-tert-Butyltetrathiatetramercaptocalix[4]arene as a Sulfur-Rich Platform for Molybdenum, Tungsten and Nickel” Chem. Commun. 2009, 289-291. Buccella, D.; Janak, K. E.; Parkin, G. “Reactivity of Mo(PMe3)6 towards Benzothiophene and Selenophenes: New Pathways Relevant to Hydrodesulfurization”. J. Am. Chem. Soc. 2008, 130(48), 16187-16189. Choi, S. H.; Kim, K.; Jeon, J.; Meka, B.; Bucella, D.; Pang, K.; Khatua, S.; Lee, J.; Churchill, D. G. “Optical Effects of S-Oxidation and Mn+ Binding in meso-Thienyl Dipyrrin Systems and of Stepwise Bromination of 4,4-Difluoro-8-(2,5-dibromo-3-thienyl)-4-bora-3a,4a-diaza-s-indacene” Inorg. Chem. 2008, 47(23), 11071-11083. Carnes, M.; Buccella, D.; Siegrist, T.; Steigerwald, M. L.; Nuckolls, C. “Reactions of Strained Hydrocarbons with Alkene and Alkyne Metathesis Catalysts” J. Am. Chem. Soc. 2008, 130(43), 14078-14079. Yurkerwich, K.; Buccella, D.; Melnick, J. G.; Parkin, G. “Monovalent Indium in a Sulfur-Rich Coordination Environment: Synthesis, Structure and Reactivity of tris(2-mercapto-1-tert-butylimidazolyl)hydroborato Indium, [TmBut]In” Chem. Commun. 2008, 3305-3307. Buccella, D.; Parkin, G. “Mononuclear and Dinuclear Molybdenum and Tungsten Complexes of p-tert-Butyltetrathiacalix[4]arene and p-tert-Butyltetrasulfonylcalix[4]arene: Facile Cleavage of the Calixarene Ligand Framework by Nickel” J. Am. Chem. Soc. 2008, 130(27), 8617-8619. Carnes, M.; Buccella, D.; Decatur, J.; Steigerwald, M. L.; Nuckolls, C. “Helical (5Z, 11E)-Dibenzoc[a,e]cyclooctatetrene: A Spring-Loaded Monomer". Angew. Chem., Intl. Ed. 2008, 47(16), 2982-2985. Melnick, J. G.; Yurkerwich, K.; Buccella, D.; Sattler, W.; Parkin, G. “Molecular Structures of Thimerosal (Merthiolate) and Other Arylthiolate Mercury Alkyl Compounds” Inorg. Chem. 2008, 47(14), 6421-6426. Figueroa, J. S.; Yurkerwich, K.; Melnick, J.; Buccella, D.; Parkin, G. Applications of Bis(1-R-imidazol-2-yl)disulfides and Diselenides as Ligands for Main-Group and Transition Metals: κ2-(N,N) Coordination, S-S Bond Cleavage, and S-S/E-E (E = S, Se) Bond Metathesis Reactions. Inorg. Chem. 2007, 46, 9234-9244. Shaw, A. P.; Ryland, B. L.; Norton, J. R.; Buccella, D.; Moscatelli, A. “Electron Exchange Involving a Sulfur-Stabilized Ruthenium Radical Cation” Inorg. Chem. 2007, 46, 5805-5812