研究领域
实验室的长远目标是探索真核细胞维持染色体稳定性的机制和细胞衰老的机理。目前主要用端粒作为特别的切入点来研究一些基础问题，比如端粒是如何保持染色体稳定性的；在常染色质和异染色质之间的边界是如何建立的；DNA双链损伤或端粒复制发生时所产生的表观遗传信息是什么；细胞衰老的分子基础又是什么。
近期论文
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1. Zhou BO, Wang SS, Zhang Y, Fu XH, Dang W, Lenzmeier BA and Zhou JQ (2011) Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae. PLOS Genet. 7: e1001272.
2. Zhou BO, Wang SS, Xu LX, Meng FL, Xuan YJ, Duan YM, Wang JY, Hu H, Dong XC, Ding JP and Zhou JQ (2010) SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation. Mol. Cell. Biol. 30: 2391-2400.
3. Zhang ML, Tong XJ, Fu XH, Zhou B, Wang JY, Liao XH, Li QJ, Shen N, Ding JP and Zhou JQ (2010) Yeast telomerase subunit Est1p has guanine quadruplex–promoting activity that is required for telomere elongation. Nat. Struct. Mol. Biol. 17: 202-209.
4. Meng FL, Hu Y, Shen N, Tong XJ, Wang JY, Ding JP and Zhou JQ (2009) Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication. EMBO J. 28: 1466-1478.
5. Chen XF, Meng FL and Zhou JQ (2009) Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae. PLOS Genet. 5: e100053.
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