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1. Discovery of a potent and selective cell division cycle 7 inhibitor from 6-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as an orally active antitumor agent.
Mingwei Fu, Min Ge, Wanxiang Yang, Chunchen Fu, Xiaowei Li, Yuanjiang Wang,* Shaohua Gou*
Acta Pharmaceutica Sinica B , 2024,14(2),893-896. DOI:10.1016/j.apsb.2023.11.026
2. A electron-accepting half-sandwich iridium(III) complex for the treatment of hypoxic tumors via synergetic chemo- and phototherapy.
Yuliang Yang, Y Gao, Jian Zhao*, Shaohua Gou*
Inorg. Chem . Frontiers , 2024, 11, 436-450. DOI:10.1039/d3qi02047a
3. Multi-targeting HDAC inhibitors containing a RAS/RAF protein interfering unit.
Yuanjiang Wang, Jianluo Zhang, Kun Li, Shengjin Xia, and Shaohua Gou*
J. Med. Chem ., 2024, 67(3), 2066-2082. DOI:10.1021/acs.jmedchem.3c01941
4. Discovery of N-(4-((6-(3,5-dimethoxyphenyl)-9H-purine derivatives as irreversible covalent FGFR inhibitors.
Yuanjiang Wang, Yanchang Pan, Zhaodan Lv, Shaohua Gou*
Eur. J. Med. Chem ., 2024, 271, 116415. DOI:10.1016/j.ejmech.2024.116415
5. Circumventing acquired drug resistance through a CK2-targeted combination via attenuating endogenous AhR-TLS-promoted genomic instability in human colorectal cancer cells.
Feihong Chen, Zhiwei Wang, Yuanjiang Wang, Shaohua Gou*
Food Chem . Toxicol. , 2023 , 176, 113774 . DOI:10.1016/j.fct.2023.113774
6. Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.
Wen Zhou, Chunping Wang, Bin Zhang, Shaohua Gou*
Eur. J. Pharmaco . , 2023, 950, 175751 . DOI:10.1016/j.ejphar.2023.175751
7. Realizing NIR-triggered type-I PDT and PTT via maximizing electronic exchange energy of perylene diimide-based photosensitizers.
Jian Zhao#, Rong Huang#, Ya Gao, Jiadong Xu, Yanyan Sun, Jiayuan Bao, Lei Fang*, Shaohua Gou*
ACS M aterials Lett. , 2023, 5 , 1752–1759. DOI:10.1021/acsmaterialslett.3c00436
8. Design of near-infrared-triggered metallo-photosensitizers via a self-assembly-induced vibronic decoupling strategy
Jian Zhao, Ya Gao, Rong Huang, Chen Chi, Yanyan Sun, Gang Xu*, Xing-Hua Xia* ,Shaohua Gou*
J. Am. Chem. Soc ., 2023, 145, 11633-11642. DOI:10.1021/jacs.3c01645
9. Naphthalene diimides functionalized half-Sandwich Ru(II) complexes as mitochondria-targeted anticancer and antimetastatic Agents.
Yuliang Yang, Xiaofeng Zou, Yanyan Sun, Feihong Chen, Jian Zhao*, Shaohua Gou*
Inorg. Chem ., 2023, 62 (24) , 9649-9660. DOI:10.1021/acs.inorgchem.3c01125
10. Study on the anticancer potency of Ru(II)/Ir(III) complexes via DNA damage and poly(ADP-ribose) polymerase 1 inhibition.
Yuliang Yang, Ya Gao, Yanyan Sun, Jian Zhao*, Shaohua Gou *
J. Med. Chem ., 2023, 66(19), 13731-13745. DOI:10.1021/acs.jmedchem.3c01156
11. Blockade of chemo-resistance to 5-FU by a CK2-targeted combination via attenuating endogenous AhR-TLS-promoted genomic instability in human colorectal cancer cells.
Zhiwei Wang, Feihong Chen, Yuanjiang Wang, Shaohua Gou*
Toxicol. App. Pharmacol. , 2023, 475, 116647.
DOI:10.1016/j.taap.2023.116647
12. Design, synthesis, and biological evaluation of a series of benzofuran [3,2-D]pyrimidine-4(1H)-ketone derivatives containing thiosemicarbazone analogs as novel PRAP-1 inhibitors.
Yuanjiang Wang, Kun Li, Wenqing Xu, Shaohua Gou*
Bioorg. Chem. , 2023, 139, 106759. DOI:10.1016/j.bioorg.2023.106759
13. Discovery of efficient hypoxia-targeted NO donor compounds to alleviate hypoxia cardiac disease .
Wanxiang Yang, Wen Zhou, Shaohua Gou*
J. Med. Chem ., 2023, 66(23), 15977-15989. DOI:10.1021/acs.jmedchem.3c01421
14. A s elf- a ssembly- i nduced e xciton d elocalization s trategy for c onverting a p erylene d iimide d erivative from a t ype-II to Type-I p hotosensitizer .
Lei Fang, Rong Huang, Wenqi Gong, Yuanhui Ji, Yanyan Sun, Shaohua Gou* ,
Jian Zhao*
Small , 2023, 2307414. DOI: 10.1002/smll.202307414
15. A s upramolecular p hotosensitizer d erived from an a rene-Ru(II) c omplex s elf-assembly for NIR a ctivated p hotodynamic and p hotothermal t herapy
Gang Xu, Chengwei Li, Chen Chi, Luyan Wu, Yanyan Sun, Jian Zhao * , Xing-Hua Xia * , Shaohua Gou *
Nature Comm. , 2022, 13(1), 3064.
16. Boosting phototherapy efficacy of NIR-absorbing ruthenium (II) complex via supramolecular engineering
Zhimei Wang , Chengwei Li , Huang, S , Ma, X , Yanyan, Jian Zhao *, Shaohua*
Materials Today Nano , 2022, 18, 100220.
17. An e ffective s upramolecular a pproach to b oost the p hotodynamic t herapy e fficacy of a n ear- i nfrared a ctivating p erylene d iimide- b ased p hotosensitizer
Chengwei Li, Ya Gao, Rong Huang, Lei Fang * , Yanyan Sun, Yuliang Yang, Shaohua Gou * , Jian Zhao*
ACS M aterials Lett. , 2022, 4(4) , pp.657-664 .
18. A hypoxia-activated NO donor for the treatment of myocardial hypoxia injury
Wen Zhou, Wanxiang Yang, Keyu Fan, Wuyang Hua, Shaohua Gou*
Chem. Sci. , 2022,13, 3549-3555.
19. Platinum(IV) p rodrugs with c ancer s tem c ell i nhibitory e ffects on l ung c ancer for o vercoming d rug r esistance
Xinyi Wang, Zhikun Liu , Yuanjiang Wang * , Shaohua Gou *
J. Med. Chem ., 2022, 65(11), 7933-7945.
20. Hypoxia-activated prodrugs with dual COX-2/CA inhibitory effects on attenuating cardiac inflammation under hypoxia
Wen Zhou, Chunping Wang, Zhikun Liu, Shaohua Gou*
J. Med. Chem ., 2022, 65(19), 13436-13451.
21. Discovery of phthalazino[1,2-b]-quinazolinone derivatives as multi-target HDAC inhibitors for the treatment of hepatocellular carcinoma via activating the p53 signal pathway
Qingqing Liu, Bin Zhang, Yuanjiang Wang, Xinyi Wang, Shaohua Gou *
Eur. J. Med. Chem ., 2022, 229, 114058.
22. Design, synthesis and anticancer evaluation of selective 2,4-disubstituted pyrimidine CDK9 inhibitors
Zichen Xu, Bin Zhang, Zhikun Liu, Shaohua Gou*
Eur. J. Med. Chem ., 2022, 244, 114875.
23. Design, synthesis and biological evaluation of antitumor platinum(II) agents conjugated with non-steroidal anti-inflammatory drug species
Ju Zang, Bin Zhang, Yuanjiang Wang, Xinyi Wang, Shaohua Gou*
Bioorg. Chem. , 2022, 120, 105633.
24. A unique chemo-photodynamic antitumor approach to suppress hypoxia via ultrathin graphitic carbon nitride nanosheets supported a platinum(IV) prodrug
Zichen Xu, Yongzhi Yu, Jian Zhao, Zhixin Liao, Yanyan Sun, Shaohua Gou*
Inorg. Chem ., 2022, 61, 20346-20357.
25. Novel CK2 specific Pt(II) compound reverses cisplatin-mediated resistance by inhibiting cancer cell stemness and suppressing DNA damage repair in NSCLC treatments
Yuanjiang Wang, Xinyi Wang, Gang Xu, Shaohua Gou*
J. Med. Chem ., 2021, 64(7), 4163-4178.
26. Discovery of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine derivatives as highly selective CK2 inhibitors with potent cancer cell stemness inhibition
Yuanjiang Wang, Zhaodan Lv, Feihong Chen, XingWang, Shaohua Gou*
J. Med. Chem. , 2021,64(8), 5082-5098.
27. Discoveryof 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol derivatives as glutathione transferase inhibitors with favorable selectivity and tolerated toxicity
Qingqing Liu, Zhikun Liu, Wuyang Hua, ShaohuaGou*
J. Med. Chem. , 2021, 64(3), 1701-1702.
28. Conjugatesderived from lapatinib derivatives with cancer cell stemness inhibitors effectively reversed drug resistance in triple- negative breast cancer.
Yuanjiang Wang, Zhaodan Lv, Feihong Chen, Xing Wang,Shaohua Gou*
J. Med. Chem. , 2021, 64(17), 12877-12892.
29. Blood-brain barrier permeable and NO-releasing multifunctional nanoparticles for Alzheimer’s diseasetreatment: Targeting NO/cGMP/CREB signaling pathways.
Zhikun Liua, Qingqing Liu,Bin Zhang, Qiao Liu, Lei Fang*, Shaohua Gou*
J. Med. Chem. , 2021,64(18), 13853-13872.
30. ROS-Responsive and multifunctional anti-Alzheimer prodrugs: Tacrine-ibuprofen hybrids via a phenylboronate linker
Zhikun Liu, Bin Zhang, Shengjin Xia, Lei Fang *, Shaohua Gou *
Eur. J. Med. Chem. , 2021, 212, 112997.
31. Design, synthesis and biological evaluation of sulfamoylphenyl-quinazoline derivatives as potentia lEGFR/CAIX dual inhibitors
Bin Zhang, Zhikun Liu, Shengjin Xia, Qingqing Liu, Shaohua Gou *
Eur. J. Med. Chem. , 2021, 216, 113300.
32. An Iridium(III) complex bearing a donor-acceptor-donor type ligand for NIR-triggered dual phototherapy .
Jian Zhao, Kaiwen Yan, Gang Xu, Qiang Zhao,Chenjie Xu*, Shaohua Gou*
Adv. Func. Materials , 2021, 31(11), 2008325.
33. A light-controlled multi-step drug release nanosystem targeting tumor hypoxia for synergistic cancer therapy.
Bin Zhang, Zichen Xu, Wen Zhou, Zhikun Liu, Jian Zhao*, Shaohua Gou*
Chem. Sci ., 2021, 12, 11810–11820.
34. The introduction of immunosuppressor (TDO inhibitor) significantly improved theefficacy of irinotecan in treating hepatocellular carcinoma
Qingqing Liu, Shixian Hua, XinyiWang, Feihong Chen*, Shaohua Gou*
Cancer Immunology Immunotherapy , 21, 70, 497-508.
35. Breakdown of chemo-immune resistance by a TDO2-targeted Pt(IV) prodrug via attenuating endogenous Kyn-AhR-AQP4 metabolic circuity andTLS-promoted genomic instability
Feihong Chen, Gang Xu, Wenyuan Tian, Shaohua Gou*
Biochem. Pharmacology , 2021, 114785.
36. Platinum-based modification of styrylbenzylsulfonesas multifunctional antitumor agents: Targeting the RAS-RAF pathway, enhancing antitumor activity and overcoming multidrug resistance
Zhikun Liu, Meng Wang, Hengshan Wang, Lei Fang*, Shaohua Gou*
J. Med. Chem. , 2020,63, 186-204.
37. Targeting RAS-RAF pathway significantly improves antitumor activity of Rigosertib- derived platinum(IV) complexes and overcome cisplatin resistance
Zhikun Liu, Meng Wang, Hengshan Wang, Lei Fang*, Shaohua Gou*
Eur. J. Med. Chem. , 2020, 194, 12269.
38. Dual-functional conjugates improving cancer immunochemotherapy by inhibiting tubulin polymerization and indoleamine-2,3 -dioxygenase
Shixian Hua, Feihong Chen, Xinyi Wang, Shaohua Gou*
Eur. J. Med. Chem. , 2020, 189, 112041
39. Iridium (III) complexes derived polymeric micelles with low dark toxicity and strong NIR excitation for phototherapy and chemotherapy
Jian Zhao, Xinzhong Zhang, LeiFang*, Chuanzhu Gao, Chenjie Xu*, Shaohua Gou*
Small , 2020, 16(14), 2000363.
40. Enhancing photodynamic therapy efficacy of upconversion-based nanoparticles conjugated with a long-lived triplet excited state iridium(III)-naphthalimide complex: toward highly enhanced hypoxia-inducible factor-1
Jian Zhao, Shuchen Sun, Xiaoyan Li, Wenjing Zhang,* Shaohua Gou*
ACS Appl. Bio Mater. 2020, 3, 252 − 262.
41. Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenase
Shixian Hua ,Feihong Chen, Shaohua Gou*
Eur. J. Med. Chem. , 2020, 187, 111949.
42. Design of a tris-heteroleptic Ru(II) complex with red-light excitation and remarkably improved photobiological activity
Shuang Li, JianZhao*, Xinyi Wang, Gang Xu, Shaohua Gou*, Qiang Zhao*
Inorg. Chem ., 2020, 59(15), 11193-11204.
43. Construction of dual stimuli-responsive platinum(IV) hybrids with NQO1 targeting ability and overcoming cisplatin resistance
Lei Fang, Xiaodong Qin, Jian Zhao, Shaohua Gou*
Inorg. Chem ., 2019, 58, 2291-2200.
44. Dinuclear organoruthenium complexes exhibit antiproliferative activity through DNA damage and ROS-mediated ER stress pathway
JianZhao, Shuang Li, Xinyi Wang, Gang Xu, Shaohua Gou*
Inorg. Chem ., 2019, 58, 2208-2217.
45. Multifunctional platinum(IV) complexes as immuno stimulatory agents to promote cancer immunochemotherapy by inhibiting tryptophan-2,3-dioxygenase
Shixian Hua, Feihong Chen,Gang Xu, Shaohua Gou*
Eur. J. Med. Chem. , 2019, 169, 29-41.
46. SHR-A1403, a c-Met antibody-drug conjugate, exerts encouraging anti-tumor activity in c-Met-overexpressed models
Changyong Yang, Lei Wang, Xing Sun, Mi Tang, Haitian Quan, Lianshan Zhang, Liguang Lou*, Shaohua Gou*
Acta Pharmcologic Sinica , 2019, 40(7),971-979.
47. Promoting antitumor efficacy by suppressing hypoxia via nano self-assembly of two irinotecan-based dual drug conjugates owning a HIF-1a inhibitor
Bin Zhang, Xiaochao Huang, Hengshan Wang*, Shaohua Gou*
J. Materials Chem. B , 2019, 7, 5352 - 5362.
48. Pt(IV) complexes conjugating with chalcone analogue as inhibitors of microtubule polymerizationexhibited selective inhibition in humancancer cells.
Xiaochao Huang, Rizhen Huang, Zhimei Wang, Lingxue Li, Shaohua Gou*, Zhixin Liao, Hengshan Wang*
Eur. J. Med. Chem. , 2018, 146, 435-450.
49. Dual-targeting antitumor hybrids derived from Pt(IV) species and millepachine analogues
Xiaochao Huang, Shixian Hua, Rizhen Huang, Zhikun Liu, Shaohua Gou*, Zhimei Wang, Zhixin Liao, Hengshan Wang*
Eur. J. Med. Chem. , 2018, 148, 1-25.
50. Theranostic Pt(IV) conjugatewith target selectivity for androgen receptor
Xiaodong Qin, Lei Fang, Jian Zhao, Shaohua Gou*
Inorg. Chem ., 2018, 57(9),5019-5029.
51. Pt(IV)prodrugs containing microtubulin inhibitors displayed potent antitumor activityand ability to overcome cisplatin resistance
Lingxue Li, Xiaochao Huang, Rizhen Huang, Shaohua Gou*, Zhimei Wang, Hengshan Wang*
Eur. J. Med. Chem. , 2018, 156, 666-679 .
52. Hypoxia-targeting organometallic Ru(II) arene complexes with enhanced anticancer activity in hypoxic cancer cells
Jian Zhao, Wanchun Li, Shaohua Gou*, Shuang Li, Shengqiu Lin, Qianhui Wei, Gang Xu*
Inorg. Chem ., 2018, 57, 8396-8403.
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