个人简介

B.A. Chemistry, University of Southern Maine, 1986 Ph.D. Organic Chemistry, University of Southern California, 1988

研究领域

Biological Chemistry

Over the years we have developed high-throughput methods to accelerate the understanding of proteins and the molecules that control them. We have examined entire bacterial organisms as well as complete protein families like human G-protein coupled receptors. One of our primary interests is applying these tools to study the chemistry and biology of neurotransmission, and of diseases that affect neurobiology (how does the brain work at the molecular level?). We want to understand how neuronal cells function on a molecular level and, and on the basis of that understanding, create new molecules and materials that mimic neuronal signal transduction and recognition. To date and using structure guided drug discovery, we have develop a number of therapeutic molecules now on the market or in clinical development to treat various diseases that affect mankind. We use a combination of chemistry, biochemistry, structural biology, cell biology, and pharmacology to accomplish the goals. Most recently, we have moved to USC to create the Bridge@USC, a new institute focused on the convergence of the sciences to understand the complete human body at the molecular, cellular, and human scale.

近期论文

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K. Zhang, J. Zhang, Z. G. Gao, D. Zhang, L. Zhu, G. W. Han, S. M. Moss, S. Paoletta, E. Kiselev, W. Lu, G. Fenalti, W. Zhang, C. Muller, H. Yang, H. Jiang, V. Cherezov, V. Katritch, K. A. Jacobson, R. C. Stevens, B. Wu and Q. Zhao (2014) Structure of the human P2Y12 receptor in complex with an antithrombotic drug Nature 509: 115-118 ; J. Zhang, K. Zhang, Z. G. Gao, S. Paoletta, D. Zhang, G. W. Han, T. Li, L. Ma, W. Zhang, C. Muller, H. Yang, H. Jiang, V. Cherezov, V. Katritch, K. A. Jacobson, R. C. Stevens, B. Wu and Q. Zhao (2014) Agonist-bound structure of the human P2Y12 receptor Nature 509: 119-122 ; H. Wu, C. Wang, K. J. Gregory, G. W. Han, H. P. Cho, Y. Xia, C. M. Niswender, V. Katritch, J. Meiler, V. Cherezov, P. J. Conn and R. C. Stevens (2014) Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator Science 344: 58-64 ; U. Weierstall, D. James, C. Wang, T. A. White, D. Wang, W. Liu, J. C. Spence, R. Bruce Doak, G. Nelson, P. Fromme, R. Fromme, I. Grotjohann, C. Kupitz, N. A. Zatsepin, H. Liu, S. Basu, D. Wacker, G. W. Han, V. Katritch, S. Boutet, M. Messerschmidt, G. J. Williams, J. E. Koglin, M. Marvin Seibert, M. Klinker, C. Gati, R. L. Shoeman, A. Barty, H. N. Chapman, R. A. Kirian, K. R. Beyerlein, R. C. Stevens, D. Li, S. T. Shah, N. Howe, M. Caffrey and V. Cherezov (2014) Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography Nat Commun 5: 3309 ; C. Wang, H. Wu, T. Evron, E. Vardy, G. W. Han, X. P. Huang, S. J. Hufeisen, T. J. Mangano, D. J. Urban, V. Katritch, V. Cherezov, M. G. Caron, B. L. Roth and R. C. Stevens (2014) Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs Nat Commun 5: 4355 ; A. A. Skjevik, M. Mileni, A. Baumann, O. Halskau, K. Teigen, R. C. Stevens and A. Martinez (2014) The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes J Mol Biol 426: 150-68 ; V. Katritch, G. Fenalti, E. E. Abola, B. L. Roth, V. Cherezov and R. C. Stevens (2014) Allosteric sodium in class A GPCR signaling Trends Biochem Sci K. Hollenstein, C. de Graaf, A. Bortolato, M. W. Wang, F. H. Marshall and R. C. Stevens (2014) Insights into the structure of class B GPCRs Trends Pharmacol Sci 35: 12-22 ; G. Fenalti, P. M. Giguere, V. Katritch, X. P. Huang, A. A. Thompson, V. Cherezov, B. L. Roth and R. C. Stevens (2014) Molecular control of delta-opioid receptor signalling Nature 506: 191-6 ;