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个人简介

1982年南京大学本科毕业,同年进入中科院就读研究生并入选CUSBEA项目,1983年赴美,1989年获哥伦比亚大学博士,在哥伦比亚大学医学院及洛克菲勒大学完成博士后研究。1993-2010年,历任美国Genentech公司科学家/实验室主任、资深科学家。期间于2003年荣获国家自然科学基金委“海外杰青”。2010年全职回国。担任仁济医院干细胞研究中心主任。

研究领域

长期致力于“干细胞与组织发育修复”和“肿瘤发生发展(包括肿瘤干细胞)”机制研究。

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Yang R, Wang M, Wang J, Huang X, Yang R, Gao WQ. (2015). Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling. Stem Cell Reports. 2015 Nov 10;5(5):816-28. 2. Quan Y, Wang N, Chen Q, Xu J, Cheng W, Di M, Xia W, Gao W-Q (2015). SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway. Oncotarget. 2015 Sep 22;6(28):26494-507. 3. Zhu HH, Zhuang G, Gao W-Q (2015). A candidate gastric stem/progenitor cell marker revealed by genome-wide analysis. J Pathol. 2015 Aug 27. doi: 10.1002/path.4601. [Epub ahead of print] 4. Zhang Q, Qin J, Zhong L, Gong L, Zhang B, Zhang Y, Gao W-Q (2015). CCL5-mediated Th2 immune polarization promotes metastasis in luminal breast cancer. Cancer Res. 2015 Aug 6. pii: canres.3590.2014. [Epub ahead of print] 5. Qin Y, Gao W-Q (2015).Concise Reviews: Patient-Derived Stem Cell Research for Monogenic Disorders. Stem Cells. 2015 Jul 31. doi: 10.1002/stem.2112. [Epub ahead of print]. 5. Chang YL, Zhou PJ, Wei L, Li W, Ji Z, Fang YX, Gao W-Q (2015). MicroRNA-7 inhibits the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway. Oncotarget. 2015 Sep 15;6(27):24017-31. 6. Wang N, Yao M, Xu J, Quan Y, Zhang K, Yang R and Gao WQ. Autocrine activation of CHRM3 promotes prostate cancer growth and castration resistance via CaM/CaMKK-mediated phosphorylation of Akt. Clinical Cancer Research. 2015 Oct 15;21(20):4676-85. 7. Liu W, Wu H, Chen L, Wen Y, Kong X, Gao WQ. Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis. Cell Res. 2015 Jun;25(6):691-706. (IF=12.41). 8. Zhang K, Zhao H, Ji Z, Zhang C, Zhou P, Wang L, Chen Q, Wang J, Zhang P, Chen Z, Zhu HH, Gao WQ. Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition. Oncogene. 2015 Jun 8. doi: 10.1038/onc.2015.184. [Epub ahead of print] 9. Qin Y, Qin J, Zhou C, Li J, Gao WQ. Generation of embryonic stem cells from mouse adipose-tissue derived cells via somatic cell nuclear transfer. Cell Cycle. 2015;14(8):1282-90. 10. Li X, Liu Y, Chen W, Fang Y, Xu H, Zhu H, Chu M, Li W, Zhuang G, Gao WQ. TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer. Oncotarget. 2014, 5(19):9498-513. IF=6.627. 11. Zhou Z, Ji Z, Wang Y, Li J, Cao H, Zhu HH, Gao WQ. TRIM59 Is Up-Regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of P53. Gastroenterology. 2014 Jul 18. pii: S0016-5085(14)00917-2. IF= 16.716. 12. Wang J, Zhu HH, Chu M, Liu Y, Zhang C, Liu G, Yang X, Yang R, Gao WQ. Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages. Nat Commun. 2014 Aug 28;5:4758. doi: 10.1038/ncomms5758. 13. Li J, Tang YH, Wang YT, Tang RB, Jiang WF, Yang GY and Gao WQ. Neurovascular recovery via co-transplanted neural and vascular progenitors leads to improved functional restoration after ischemic stroke in rat. Stem Cell Reports. 2014 Jun 19;3(1):101-14. 14. Li J, Xuan JW, Khatamianfar V, Valiyewa F, Moussa M, Sadek A, Yang BB, Dong BJ, Huang YR, Gao WQ. SKA1 overexpression promotes centriole over duplication, centrosome amplification and prostate tumorigenesis. J Pathol. 2014 Oct;234(2):178-89. 15. Fang, Y and Gao W-Q. Roles of miRNAs during prostate tumorigenesis and tumor progression. Oncogene, 2013 Mar 4. doi: 10.1038/onc.2013.54. 16. Sun Y, Wang BE, Leong KG, Yue P, Li L, Jhunjhunwala S, Chen D, Seo K, Modrusan Z, Gao WQ*, Settleman J*, Johnson L*. Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy. Cancer Res. 2012 Jan 15;72(2):527-36. 17. Vitari AC, Leong KG, Newton K, Yee C, O'Rourke K, Liu J, Phu L, Vij R,Ferrando R, Couto SS, Mohan S, Pandita A, Hongo JA, Arnott D, Wertz IE, Gao WQ, French DM, Dixit VM. COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature. 2011 May 15;474(7351):403-6. 18. Leong KG, Wang BE, Johnson L, Gao WQ. Generation of a prostate from a single adult stem cell. Nature. 2008 Dec 11;456(7223):804-8 (封面文章). 19. Leow CC, Romero MS, Ross S, Polakis P, Gao WQ. Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells. Cancer Res. 2004 Sep 1;64(17):6050-7. 20. Shou J, Soriano R, Hayward SW, Cunha GR, Williams PM, Gao WQ. Expression profiling of a human cell line model of prostatic cancer reveals a direct involvement of interferon signaling in prostate tumor progression. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2830-5.

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