封文海 - 中国农业大学

个人简介

博士，教授，博士生导师。1999年毕业于美国北卡罗来纳州立大学(North Carolina State University), 获免疫学博士学位。随后在美国北卡罗来纳大学（University of North Carolina-Chapel Hill）医学院做博士后，并于2003年留该校医学院工作，从事Epstein-Barr virus(EBV)致病机理及EBV相关癌症基因治疗方法的研究工作。2007年3月应聘为中国农业大学特聘教授，任生物学院微生物及免疫学系及农业生物技术国家重点实验室教授和博士生导师。　　学习与工作经历 1982年9月--1987年7月北京农业大学动物医学院学士 1987年7月--1990年7月北京农业大学动物医学院硕士（传染病） 1990年7月--1993年7月北京农业大学动物医学院助教 1993年8月--1995年12月美国Iowa State University 硕士（免疫学） 1996年1月--1999年12月美国North Carolina state University 博士（免疫学） 2000年1月--2003年7月美国University of North Carolina 医学院博士后 2003年8月--2007年3月，美国University of North Carolina 医学院 Senior Scientist 2007年3月--(原北京农业大学)特聘教授社会兼职中国工程院院刊农业学部分刊 FASE 编委中国兽医杂志编委中国微生物学会病毒学专业委员会委员 Virologica Sinica Editor

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Liu Y, Du Y, Wang H, Du L, andWen-hai Feng*. 2017. Porcine reproductive and respiratory syndrome virus (PRRSV) up-regulates IL-8 expression through TAK-1/JNK/AP-1 pathways. Virology. 506:64-72 2.Liu F, Du Y, andWen-hai Feng*. 2017. New perspective of host microRNAs in the control of PRRSV infection. Vet Microbiology. S0378-1135(16)30612-5. Yu Z, Huang C, Zhang Q, and Wen-hai Feng*. 2016. Porcine reproductive and respiratory syndrome virus (PRRSV) induces IL-12p40 production through JNK-AP-1 and NF-κB signaling pathways. Virus Res. 225:73-81 Du L, Liu Y, Du Y, Wang H, Zhang M, Du Y, and Wen-hai Feng*.2016. Porcine reproductive and respiratory syndrome virus (PRRSV) up-regulates IL-15 through PKCβ1-TAK1-NF-κB signaling pathway. Virology 496:166-74. Huang C, Du Y, Yu Z, Zhang Q, Liu Y, Tang J, Shi J, and Wen-hai Feng*. 2016. Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Nsp4 Cleaves VISA to Impair Antiviral Responses Mediated by RIG-I-like Receptors. Scientific Reports 6:28497 Zhang Q, Huang C, Yang Q, Gao L, Liu HC, Tang J, and Wen-hai Feng*. 2016. MicroRNA-30c Modulates Type I IFN Responses To Facilitate Porcine Reproductive and Respiratory Syndrome Virus Infection by Targeting JAK1. Journal of Immunology 196(5):2272-82. Gao L, Wang L, Huang C, Yang L, Guo XK, Yu Z, Liu Y, Yang P, and Wen-hai Feng*. 2015. HP-PRRSV is attenuated by de-optimization of codon pair bias in its RNA-dependent RNA polymerase nsp9 gene. Virology485:135-44. Yang Q, Zhang Q, Tang J, and Wen-hai Feng*. 2015. Lipid rafts both in cellular membrane and viral envelope are critical for PRRSV efficient infection. Virology 484:170-180. Huang C, Zhang Q, and Wen-hai Feng*. 2014. Regulation and evasion of antiviral immune responses by?porcine?reproductive?and?respiratorysyndrome?virus.Virus Res. 202:101-11. Wang L, Hou J, Gao L, Guo XK, Yu Z, Zhu Y, Liu Y, Tang J, Zhang H, and Wen-hai Feng*. 2014. Attenuation of highly pathogenic?porcine?reproductive?and?respiratory?syndrome?virus?by inserting an additional transcription unit. Vaccine 32(43):5740-8. Huang C, Zhang Q, Guo XK, Yu ZB, Xu AT, Tang J, and Wen-hai Feng*. 2014. Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 4 Antagonizes IFNbeta Expression by Targeting NEMO. Journal of virology88(18): 10934-10945. Zhao H, Guo XK, Bi Y, Zhu Y, and Wen-hai Feng*. 2014. PKCσ is required for porcine reproductive and respiratory syndrome virus replication. Virology 468-470:96-103. Chen XX, Quan R, Guo XK, Gao L, Shi J, and Wen-hai Feng*. 2014. Up-regulation of pro-inflammatory factors by HP-PRRSV infection in microglia: implications for HP-PRRSV neuropathogenesis. Vet Microbiol. 170(1-2):48-57. Zhang Q, Guo XK, Gao L, Huang C, Li N, Jia X, Liu W, and Wen-hai Feng*. 2014. MicroRNA-23 inhibits PRRSV replication by directly targeting PRRSV RNA and possibly by upregulating type I interferons. Virology 450-451:182-95. Zhao H, Wang Y, Ma Z, Wang Y, and Wen-hai Feng*. 2014. Recombinant Kluyveromyces lactis expressing highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) GP5 elicits mucosal and cell-mediated immune responses in mice. J Vet Sci. 15(2):199-208. Bi Y, Guo XK, Zhao H, Gao L, Wang L, Tang J, and Wen-hai Feng*. 2014. Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Induces Prostaglandin E2 Production through Cyclooxygenase 1, Which Is Dependent on the ERK1/2-p-C/EBP-β Pathway. Journal of Virology 88(5):2810-20. Ma Z, Zhang W, Wang L, Zhu M, Wang H, and Wen-hai Feng*, Ng TB. 2013. A novel compound from the mushroom Cryptoporus volvatus inhibits porcine reproductive and respiratory syndrome virus (PRRSV) in vitro. PLoS One 8(11):e79333. Ma Z, Wang Y, Zhao H, Xu AT, Wang Y, Tang J, and Wen-hai Feng*. 2013.Porcine reproductive and respiratory syndrome virus nonstructural protein 4 induces apoptosis dependent on its 3C-like serine protease activity. PLoS One8(7):e69387. Wang Y, Zhao H, Ma Z, Wang Y, and Wen-hai Feng*. 2013.CTLA4 mediated targeting enhances immunogenicity against PRRSV in a DNA prime/killed virus boost strategy. Vet Immunol Immunopathol. 154(3-4):121-8. Gao L, Guo XK, Wang L, Zhang Q, Li N, Chen XX, Wang Y, and Wen-hai Feng*. 2013. MicroRNA 181 suppresses porcine reproductive and respiratory syndrome virus (PRRSV) infection by targeting PRRSV receptor CD163. Journal of Virology 87(15):8808-12. Gao L, Zhang W, Sun Y, Yang Q, Ren J, Liu J, Wang H, and Wen-hai Feng*. 2013. Cryptoporus volvatus extract inhibits porcine reproductive and respiratory syndrome virus (PRRSV) in vitro and in vivo. PLoS One. 8(5):e63767. Yang Q, Gao L, Si J, Sun Y, Liu J, Cao L, and Wen-hai Feng*. 2013. Inhibition of porcine reproductive and respiratory syndrome virus replication by flavaspidic acid AB. Antiviral Res. 97(1):66-73.. Guo XK, Zhang Q, Gao L, Li N, Chen XX, and Wen-hai Feng*. 2013. Increasing expression of microRNA 181 inhibits porcine reproductive and respiratory syndrome virus replication and has implications for controlling virus infection. Journal of Virology 87(2):1159-71. Wang L, Hou J, Zhang H, and Wen-hai Feng*. 2012.Complete genome sequence of a novel highly pathogenic porcine reproductive and respiratory syndrome virus variant. Journal of Virology 86(23):13121. Hou J, Wang L, Quan R, Fu Y, Zhang H, and Wen-hai Feng*. 2012. Induction of interleukin-10 is dependent on p38 mitogen-activated protein kinase pathway in macrophages infected with porcine reproductive and respiratory syndrome virus. Virol J. 2012 Aug 21;9:165. Fu Y, Quan R, Zhang H, Hou J, Tang J, and Wen-hai Feng*. 2012. Porcine reproductive and respiratory syndrome virus induces interleukin-15 through the NF-κB signaling pathway. Journal of Virology 86(14):7625-36. Hou J, Wang L, He W, Zhang H, and Wen-hai Feng*. 2012Highly pathogenic porcine reproductive and respiratory syndrome virus impairs LPS- and poly(I:C)-stimulated tumor necrosis factor-alpha release by inhibiting ERK signaling pathway. Virus Res. 167(1):106-11. Wang L, Zhang H, Suo X, Zheng S, and Wen-hai Feng*. 2011. Increase of CD163 but not sialoadhesin on cultured peripheral blood monocytes is coordinated with enhanced susceptibility to porcine reproductive and respiratory syndrome virus infection. Vet Immunol Immunopathol. 141(3-4):209-20. Quan, R., Y. Fu, W. He, and Wen-hai Feng*. 2012. Cloning and characterization of the porcine IL-10 promoter. Vet Immunol Immunopathol. 146:277-282. Wen-hai Feng, Tompkins, M.B., Xu, J.S., Zhang, H.X., McCaw, M.B., 2003. Analysis of constitutive cytokine expression by pigs infected in-utero with porcine reproductive and respiratory syndrome virus. Vet. Immunol. Immunopathol. 94(1-2):35-45. Wen-hai Feng, Tompkins, M, Xu, jin-shen, Brown, T, Laster, S, Zhang, He-xiao, and McCaw, M.B.2002. Thymocyte and peripheral blood T lymphocyte subpopulation changes in piglets following in-uteroinfection with porcine reproductive and respiratory syndrome virus. Virology 302 (2): 363-372. Wen-hai Feng, S. M. Laster, M. Tompkins, T. Brown, J.-S. Xu, C. Altier, W. Gomez, D. Benfield, and M. B. McCaw. 2001. In Utero Infection by Porcine Reproductive and Respiratory Syndrome Virus Is Sufficient To Increase Susceptibility of Piglets to Challenge by Streptococcus suis Type II. Journal of Virology 75:4889-4895. EBV相关文章： Yinping Du, Jieshi Yu, Li Du, JunTang, and Wen-Hai Feng*. 2016. Cordycepin enhances Epstein–Barr virus lytic infection and Epstein–Barr virus-positive tumor treatment efficacy by doxorubicin Epstein–Barr virus-positive tumor treatment efficacy by doxorubicin. Cancer letters, 376:240–248. Wen-hai Feng,and Shannon C. Kenney. 2007. ZEB positively regulates the lytic-switch BZLF1 gene promoter of Epstein-Barr virus in AGS cells. Journal of Virology, 81: 10113-22. Jones RJ, Seaman WT, Feng Wen-hai, Tsao SW, Man C, Delecluse HJ, and Kenney SC. 2007. Roles of lytic viral infection and IL-6 in early versus late passage lymphoblastoid cell lines and EBV-associated lymphoproliferative disease. International Journal of Cancer, 121(6):1274-81。 Bhende, PM, Dickerson, S., Feng, Wen-hai, and Kenney SC. 2007. The plasma cell differentiation factor, X-box-binding protein 1 (XBP-1), activates lytic Epstein-Barr virus gene expression in combination with Protein Kinase D (PKD). Journal of Virology, 81(14): 7363-70. Wen-hai Feng,and Shannon C. Kenney. 2006. Valproic acid enhances chemoagents to treat EBV-positive tumors. Cancer Research, 66 (17) 8762-8768. Bruce F. Israel, Margaret Gulley, Sandra Elmore, Silvano Ferrini, Wen-hai Feng, and Shannon C. Kenney. 2005. Anti-CD70 antibodies: a potential treatment for EBV-positive CD70-expressing lymphomas. Molecular Cancer Therapeutic, 4(12) 2037-2044. Gregory K. Hong, Margaret L. Gulley, Wen-hai Feng, Henri-Jacques Delecluse, Elizabeth Holley-Guthrie, and Shannon C. Kenney. 2005. Epstein-Barr Virus Lytic Infection Contributes to Lymphoproliferative Disease in a SCID Mouse Model. Journal of Virology, 79: 13993-14003. Gregory K. Hong, Henri-Jacques Delecluse, Henri Gruffat, Thomas E. Morrison, Wen-hai Feng, and Shannon C. Kenney. 2004. The BRRF1 early gene of Epstein-Barr virus encodes a transcription factor that enhances induction of lytic infection by BRLF1 Journal of Virology, 78:4983-4992. Wen-hai Feng, Jeffrey I. Cohen, Henri-Jacques Delecluse, and Shannon C. Kenney. 2004. Methotrexate induces reactivation of latent Epstein-Barr virus (EBV): a potential contributor to methotrexate-associated lymphomas. Journal of the National Cancer Institute, 96(22):1691-1702. Wen-hai Feng, Gregory Hong, Henri-Jacques Delecluse, and Shannon C. Kenney. Lytic induction therapy for Epstein-Barr virus-positive B-cell lymphomas. 2004. Journal of Virology, 78:1893-1902. Wen-hai Feng, Bruce Israel, Nancy Raab-Traub, Pierre Busson, and Shannon C. Kenney. 2002. Chemotherapy induces lytic Epstein-Barr virus (EBV) replication and confers ganciclovir susceptibility to EBV-positive epithelial cell tumors. Cancer Research, 62: 1920-1926. Wen-hai Feng, Eva Westphal, Amy Mauser, Nancy Raab-Traub, Margaret L. Gulley, Pierre Busson, and Shannon C. Kenney. 2002. Use of Adenovirus vectors expressing the Epstein-Barr virus (EBV) immediate-early proteins (BZLF1 or BRLF1) to treat Nasopharyngeal Carcinomas in vivo. Journal of Virology, 76:10951-10959. Eva M. Westphal, William Blackstock, Wen-hai Feng, Bruce Israel, and Shannon C. Kenney. 2000. Activation of Lytic Epstein-Barr Virus (EBV) Infection by Radiation and Sodium Butyrate in Vitro and in Vivo: A Potential Method for Treating EBV-positive Malignancies. Cancer Research, 60: 5781-5788.

个人简介

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