Lu, Yi - University of Illinois at Urbana-Champaign

个人简介

Dr. Yi Lu graduated with a B.S. in Chemistry from Peking University in 1986 and received his Ph.D. degree from UCLA in 1992 under Dr. Joan S. Valentine. After two years of postdoctoral research in the group of Dr. Harry B. Gray at the Caltech, Dr. Lu started his own independent career in the Department of Chemistry at the University of Illinois at Urbana-Champaign in 1994. He is now Jay and Ann Schenck Professor in the Departments of Chemistry, Biochemistry, Materials Science and Engineering and Bioengineering. He is also a member of the Center for Biophysics and Quantitative Biology and the Carl R. Woese Institute for Genomic Biology. He holds a joint appointment at Pacific Northwest National Laboratory Dr. Lu has received numerous research and teaching awards, including the Royal Society of Chemistry Joseph Chatt Award (2020), Applied Inorganic Chemistry Award (2015), Fellow of the Royal Society of Chemistry (FRSC, 2015), Fellow of the American Association for the Advancement of Science (2007), Early Career Award from the Society of Biological Inorganic Chemistry (2007), Howard Hughes Medical Institute Professor Award (2002), Camile Dreyfus Teacher-Scholar Award (1999), Alfred P. Sloan Research Fellowship (1998), Research Corporation Cottrell Scholars Award (1997), and Beckman Young Investigators Award (1996). Dr. Lu is also at the forefront in innovation in teaching. Research in his lab has resulted in more than 50 US and international patents as well as successful products in environmental monitoring and medical diagnostics.

研究领域

The Lu group’s interests lie at the interface between chemistry and biology. We are developing innovative chemical approaches to provide deeper insight into biological structures and functions. We are also taking advantage of recently developed biological tools to advance many areas in chemistry, such as inorganic chemistry, chemical biology, analytical chemistry, and materials chemistry. We strive to make significant contributions in three principal areas of research: 1. Biosynthetic Inorganic Chemistry Synthesis and study of structural and functional mimics of metalloenzymes and their applications as biocatalysts in renewable energy generation and small-molecule activation and transformation. 2. DNAzyme and Aptamer-Based Sensing and Imaging Agents In vitro selection of DNAzymes/aptamers and development of highly sensitive and selective sensors and imaging agents for metal ions and small-molecule targets with applications in environmental monitoring, food safety, and medical diagnostics and imaging. 3. Functional DNA Nanotechnology Using DNA for encoded synthesis and directed assembly of nanomaterials and their applications as theranostic agents for early detection of diseases such as cancers and targeted drug delivery.

近期论文

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Mingkuan Lyu, Linggen Kong, Zhenglin Yang, Yuting Wu, Claire E. McGhee, and Yi Lu "PNA-Assisted DNAzymes to Cleave Double-Stranded DNA for Genetic Engineering with High Sequence Fidelity" J. Am. Chem. Soc. (in press) (2021) Erin M. McConnell, Ioana Cozmaa, Quanbing Mou, John D. Brennan, Yi Lu and Yingfu Li "Biosensing with DNAzymes" Chem Soc. Rev. (in press) (2021) Avery C. Vilbert, Yiwei Liu, Huiguang Dai, Yi Lu "Recent advances in tuning redox properties of electron transfer centers in metalloenzymes catalyzing oxygen reduction reaction and H2 oxidation important for fuel cells design" Curr. Opin. Electrochem. (in press) Songbai Zhang, Shuang Li, Rixin Yan, Zhiyun Zhou, Yuting Wu and Yi Lu "Recent advances of using personal glucose meter as a biosensor readout for non-glucose targets" Curr. Anal. Chem. (in press) (2021) Shanni Hong, Gregory T. Pawel, Renjun Pei and Yi Lu "Recent progress in developing fluorescent probes for imaging cell metabolites" Biomed. Mater. 16, 044108 (2021) Shiliang Tian, Ruixi Fan, Therese Albert, Rahul L. Khade, Huiguang Dai, Kevin A. Harnden, Parisa Hosseinzadeh, Jing Liu, Mark J. Nilges, Yong Zhang, Pierre Moënne-Loccoz, Yisong Guo, and Yi Lu "Stepwise Nitrosylation of the Nonheme Iron Site in an Engineered Azurin and a Molecular Basis for Nitric Oxide Signaling Mediated by Nonheme Iron Proteins" Chem. Sci. 12, 6569-6579 (2021) Kevin A. Harnden, Yajie Wang, Lam Vo, Huimin Zhao, and Yi Lu "Engineering Artificial Metalloenzymes"In “Protein Engineering: Tools and Applications,” Huimin Zhao, ed. (in press) (2021) Lawrence Que, Jr. and Yi Lu "Introduction"Section 8 (Biocoordination Chemistry) Lawrence Que, Jr. and Yi Lu, eds., Comprehensive Coordination Chemistry III, Edwin Constable Gerard Parkin Lawrence Que, eds. (in press) (2021) Matthew W. Waugh, Sudharsan Dwaraknath and Yi Lu "Advances in Metalloprotein Design and Engineering: Strategies Employed and Insights Gained"In Section 8 (Biocoordination Chemistry) Lawrence Que, Jr. and Yi Lu, eds., Comprehensive Coordination Chemistry III, Edwin Constable Gerard Parkin Lawrence Que, eds. (in press) (2021) Ruo-Can Qian, Ze-Rui Zhou, Weijie Guo, Yuting Wu, Zhenglin Yang, and Yi Lu "Cell Surface Engineering using DNAzymes: Metal Ion-mediated Control of Cell-Cell Interactions" J. Am. Chem. Soc. 143, 5737–5744 (2021 Shige Xing, Yao Lin, Liangyuan Cai, Prem N. Basa, Austin K. Shigemoto, Chengbin Zheng, Feng Zhang, Shawn C. Burdette and Yi Lu "Detection and Quantification of Tightly-Bound Zn2+ in Blood Serum Using a Photocaged Chelator and a DNAzyme Fluorescent Sensor" Anal. Chem. 93, 5856–5861 (2021) Wentao Xu, Wanchong He, Zaihui Du, Liye Zhu, Kunlun Huang, Yi Lu, Yunbo Luo "Functional Nucleic Acids-Nanomaterials: Development, Properties, and Applications" Angew Chemie Int. Ed. 60, 6890-6918 (2021) Songbai Zhang, Yunxia Luan, Mengyi Xiong, Jingjing Zhang, Ryan Lake, and Yi Lu "DNAzyme amplified aptasensing platform for ochratoxin A detection using personal glucose meter" ACS Appl. Mater. Interfaces (Special theme issue on Materials Applications of Aptamers) 13, 9472–9481 (2021 Igor D. Petrik, Roman Davydov, Maximilian Kahle, Braddock Sandoval, Sudharsan Dwaraknath, Pia Adelroth, Brian Hoffman, Yi Lu "An Engineered Glutamate in Biosynthetic Models of Heme-Copper Oxidases Drives Complete Product Selectivity by Tuning the Hydrogen-Bonding Network" Biochemistry 60, 346–355 (2021 Christopher J. Reed, Quan N. Lam, Evan N. Mirts and Yi Lu "Molecular understanding of heteronuclear active sites in heme–copper oxidases, nitric oxide reductases, and sulfite reductases through biomimetic modelling" Chem. Soc. Rev. 50, 2486-2539 (2021 Yiming Wang, Michael J. Counihan, Jeffrey Wayjer Lin, Joaquín Rodríguez-López, Hong Yang, and Yi Lu "Quantitative Analysis of DNA-Mediated Formation of Metal Nanocrystals" J. Am. Chem. Soc. 142, 48, 20368–20379 (2020 Evan N. Mirts, Sergei A. Dikanov, Anex Jose, Edward I. Solomon, and Yi Lu "A Binuclear CuA Center Designed in an All α-Helical Protein Scaffold" J. Am. Chem. Soc. 142, 32, 13779–13794 (2020 Sheng-Song Yu, Jun-Jie Li, Chang Cui, Shiliang Tian, Jie-Jie Chen, Han-Qing Yu, Changjun Hou, Mark J. Nilges, and Yi Lu "Structural Basis for the Quadratic Relationship between Electronic Absorption and Electronic Paramagnetic Resonance Parameters of Type 1 Copper Proteins"Inorg. Chem. 59, 10620–10627 (2020 Chang Xue, Songbai Zhang, Xin Yu, Shuyao Hu, Yi Lu, and Zai-Sheng Wu "Periodically-Ordered Nick-Hidden DNA Nanowire with Cell-Specific Aptamer Targeting Ligands as Highly Serum-Stable and Selective Theranostic Agents" Angew Chemie Int. Ed. 59, 17540–17547 (2020) Yuting Wu, Zhenglin Yang and Yi Lu "Photocaged functional nucleic acids for spatiotemporal imaging in biology" Curr. Opin. Chem. Biol. 57, 95-104 (2020