黄芝瑛 - 中山大学

个人简介

黄芝瑛，男，1988年6月毕业于暨南大学医学院毒理专业，获医学硕士学位。此后一直在广州市医药工业研究所从事新药安全评价研究及GLP工作，任副所长、国家广州新药安全评价研究重点实验室主任。2005年10月，中山大学以“百人计划”人才引进为药学院研究员、博士生导师。

研究领域

药物毒理学（毒性机制研究及筛选方法的建立等）、药物安全性评价研究与GLP（新药、药用辅料及新材料的评价研究）、动物替代实验方法的研究

近期论文

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Toosendanin induced hepatotoxicity via triggering PERK-eIF2α-ATF4 mediated ferroptosis. Liang Y, Chen S, Han S, Luo L, Shen F, Huang Zhiying*. Toxicol Lett. 2023 Mar 15;377:51-61. doi: 10.1016/j.toxlet.2023.02.006. Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction。Luo L, Liang YH, Fu YY, Liang ZY, Zheng JF, Lan J, Shen FH,* Huang Zhiying*。Pharmaceuticals. 2022, 15(12), 1509; doi.org/10.3390/ph15121509 Inhibition of p53 Sulfoconjugation Prevents Oxidative Hepatotoxicity and Acute Liver Failure。Xu P, Xi Y, Wang P, Luka Z, Xu M, Tung HC, Wang J, Ren S, Feng D, Gao B, Singhi AD, Monga SP, York JD, Ma X, Huang Zhiying, Xie W*. Gastroenterology 2022 Apr;162(4):1226-1241. The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1. Xi Y, Li Y, Xu P, Li S, Liu Z, Tung HC, Cai X, Wang J, Huang H, Wang M, Xu M, Ren S, Li S, Zhang M, Lee YJ, Huang L, Yang D, He J*, Huang Zhiying*, Xie W*. Sci Adv. 2021 Sep 3;7(36):eabg9241. doi: 10.1126/sciadv.abg9241 Triptolide impairs glycolysis by suppressing GATA4/Sp1/PFKP signaling axis in mouse Sertoli cells. Zhang Y, Tang Y, Luo Y, Luo L, Shen F*, Huang Zhiying*. Toxicol Appl Pharmacol. 2021 Aug 15;425:115606. doi: 10.1016/j.taap.2021.115606 Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis. Xu P, Xi Y, Zhu J, Zhang M, Luka Z, Stolz DB, Cai X, Xie Y, Xu M, Ren S, Huang Zhiying, Yang D, York JD, Ma X, Xie W*. Gastroenterology. 2021 Jul;161(1):271-286.e11. doi: 10.1053/j.gastro.2021.03.048 Transition metals and metal complexes in autophagy and diseases. Luo Y, Fu Y, Huang Zhiying*, Li M*. J Cell Physiol. 2021 Oct;236(10):7144-7158. doi: 10.1002/jcp.30359 New Anti-Cancer Strategy to Suppress Colorectal Cancer Growth Through Inhibition of ATG4B and Lysosome Function. Fu Y, Gu Q, Luo L, Xu J, Luo Y, Xia F, Han F, Hong L, Yin XM, Huang Zhiying*, Li M*. Cancers (Basel). 2020 Jun 10;12(6):1523. doi: 10.3390/cancers12061523 Triptolide dysregulates glucose uptake via inhibition of IKKβ-NF-κB pathway by p53 activation in cardiomyocytes. Xi Y, Zhang Y, Pan J, Chen S, Lu S, Shen F*, Huang Zhiying*, Toxicol Lett. 2020 Jan;318:1-11. doi: 10.1016/j.toxlet.2019.10.001 PPAR-Mediated Toxicology and Applied Pharmacology. Xi Y, Zhang Y, Zhu S, Luo Y, Xu P, Huang Zhiying*. Cells. 2020 Feb 3;9(2):352. doi: 10.3390/cells9020352 Triptolide induces oxidative damage in NRK-52E cells through facilitating Nrf2 degradation by ubiquitination via the GSK-3β/Fyn pathway. Pan J, Shen F, Tian K, Wang M, Xi Y, Li J, Huang Zhiying*. Toxicol In Vitro. 2019 Aug;58:187-194. doi: 10.1016/j.tiv.2019.03.032.