黄志纾 - 中山大学

个人简介

黄志纾，1965年6月生，理学博士，教授，博士生导师。中山大学药学院药物化学研究所所长。现为全国化学生物学专业委员会委员，全国药物化学专业委员会委员，全国药学专业学位工作委员会委员，广东省药学会药物化学专业委员会主任委员。主要从事药物化学、化学生物学科领域的教学和科研工作。1999年获中山大学有机化学博士学位。1998-1999年应邀在香港科技大学化学系进行中药化学的合作研究工作。2001-2003年在美国得克萨斯大学奥斯汀分校药学院药物化学系（The Division of Medicinal Chemistry, the College of Pharmacy, the University of Texas at Austin）进行博士后研究工作。先后主持国家自然科学基金重点项目、重大研究计划项目、面上项目以及省部级科研项目多项。在国内外重要学术刊物，包括 J. Am. Chem. Soc., Nucleic Acids Res., Cell Chem. Biol., J. Med. Chem., Brit. J. Pharmacol., Org. Lett., ACS Chem. Biol., Chem. Commun., Anal. Chem., Eur. J. Med. Chem., Oncogene 等发表论文200余篇，通讯或第一论文110余篇。多项中国发明专利获得授权。现为《中国药物化学杂志》、《中国药学》英文版编委。曾担任《 Current Topics in Medicinal Chemistry 》特刊客座主编，参与编写《有机化学》、《生物化学》、《药物化学》、《 Medicinal Chemistry of Nucleic Acids 》等教材和专著。曾获广东省科学技术一等奖、广东省教学成果一等奖。教育部首批国家一流本科课程《生物化学》课程负责人，曾入选教育部新世纪优秀人才、广东省特支计划领军人才和杰出人才支持计划。曾获“挑战杯”全国大学生课外学术科技作品竞赛“优秀指导教师”、“南粤优秀教师”、广东省“三八红旗手”等荣誉称号。

研究领域

1. 以核酸高级结构为靶点的药物化学生物学研究；2. 抗肿瘤、抗肥胖及其并发症创新药物的发现研究；3. 新靶点药物分子设计、合成及作用机制研究；4. 天然活性成分的结构修饰、优化及构效关系研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Design, synthesis and structure-activity relationship of novel 2-pyrimidinylindole derivatives as orally available anti-obesity agents, Eur. J. Med. Chem. 2024 , 277 ,116773 . 2. Development of Novel N-Acylhydrazone Derivatives with High Anti-obesity Activity and Improved Safety by Exploring the Pharmaceutical Properties of Aldehyde Group, J. Med. Chem. 2024 , 67(14), 12439-12458. 3. Design and Synthesis of Bouchardatine Derivatives as a Novel AMPActivated Protein Kinase Activator for the Treatment of Colorectal Cancer, J. Med. Chem. 2023 , 66 , 7387-7404 . 4. Design, synthesis and evaluation of 2-pyrimidinylindole derivatives as anti-obesity agents by regulating lipid metabolism, Eur. J. Med. Chem. 2023 , 260 ,115729 . 5. Design, Synthesis, and Evaluation of New Sugar-Substituted Imidazole Derivatives as Selective c‑MYC Transcription Repressors Targeting the Promoter G‑Quadruplex, J. Med. Chem. 2022 , 65 , 12675-12700 . 6. Discovery of a Novel G‑Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer, J. Med. Chem. 2022 , 65 , 12346-12366 . 7. A novel HSF1 activator ameliorates nonalcoholic steatohepatitis by stimulating mitochondrial adaptive oxidation, Brit. J. Pharmacol. 2022 , 179, 1411-1432. 8. Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L- aspartate via gut-liver axis, Gut Mocrobes 2021 , 13, e1927633. 9. Design, Synthesis and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom's Syndrome Protein (BLM) Helicase, Trigger DNA damage at the Telomere Region and Synergize with PARP Inhibitors, J. Med. Chem. 2020 , 63 , 9752-9772 . 10. Bouchardatine analogue alleviates NAFLD/NASH in high fat fed mice via blunting ATP synthase activity, Brit. J. Pharmacol. 2019 , 176 , 2877-2893. 11. Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair, J. Med. Chem. 2019 , 62 , 3147–3162. 12. Tigliane Diterpenoids as a New Type of Antiadipogenic Agents Inhibit GRα-Dexras1 Axis in Adipocytes, J. Med. Chem. 2019 , 62 , 2060–2070. 13. Identification of G-Quadruplex-Binding Protein from the Exploration of RGG Motif/G-Quadruplex Interactions, J. Am. Chem. Soc. 2018 , 140, 17945–17955. 14. Discovery of novel schizocommunin derivatives as telomeric G-quadruplex ligands that trigger telomere dysfunction and the deoxyribonucleic acid (DNA) damage response, J. Med. Chem. 2018 , 61 , 3436–3453. 15. Design, synthesis, and evaluation of new selective NM23-H2 binders as c-MYC transcription inhibitors via disruption of the NM23-H2/G-quadruplex interaction, J. Med. Chem. 2017 , 60 , 6924–6941. 16. New disubstituted quindoline derivatives inhibiting Burkitt’s lymphoma cell proliferation by impeding c-MYC transcription, J. Med. Chem. 2017 , 60 , 5438–5454. 17. Natural alkaloid bouchardatine ameliorates metabolic disorders in high‐fat diet‐fed mice by stimulating the sirtuin 1/liver kinase B‐1/AMPK axis, Brit. J. Pharmacol. 2017 , 174 , 2457-2470. 18. Design, synthesis and evaluation of isaindigotone derivatives to downregulate c-myc transcription via disrupting the interaction of NM23-H2 with G-quadruplex, J. Med. Chem. 2017 , 60 , 1292-1308. 19. Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole, Nucleic Acids Res. 2017 , 45 , 1606-1618 . 20. Conformation selective antibody enables genome profiling and leads to discovery of parallel G-quadruplex in human telomeres. Cell Chem. Biol. 2016 , 23 , 1261-1270. 21. Visualization of NRAS RNA G-quadruplex structures in cells with an engineered fluorogenic hybridization probe. J. Am. Chem. Soc . 2016 , 138 , 10382–10385. 22. Synthesis and mechanism studies of 1,3-benzoazolyl substituted pyrrolo[2,3 b ]pyrazine derivatives as nonintercalative topoisomerase II catalytic inhibitors, J. Med. Chem. 2016 , 59 , 238-252. 23. Synthesis and biological evaluation of novel bouchardatine derivatives as potential adipogenesis/lipogenesis inhibitors for antiobesity treatment, J. Med. Chem. 2015 , 58 , 9395-9413. 24. A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region, Oncotarget 2015 , 6 , 35625-35635. 25. Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule, Nucleic Acids Res. 2015 , 43 , 6677-6691. 26. Discovery of small molecules for up-regulating the translation of antiamyloidogenic secretase, a disintegrin and metalloproteinase 10 (ADAM10), by binding to the G-quadruplex-forming sequence in the 5′ untranslated region (UTR) of Its mRNA, J. Med. Chem. 2015 , 58 , 3875-91. 27. Identification of selective G-quadruplex DNA binder by a multistep virtual screening approach, Chem. Commun. 2015 , 51 , 198-201.

学术兼职

Current Medicinal Chemistry 编委（2016-2018） Current Topics in Medicinal Chemistry -Gust editor (2015, volume 15, number 19) 《中国药物化学杂志》编委（2010-）中国药学会药物化学专业委员会委员（2011-）中国化学会化学生物学专业委员会委员（2010-）广东省药学会药物化学专业委员会主任委员（2015-2022）