Bay, Boon Huat - National University of Singapore - Department of Anatomy Yong Loo Lin School of Medicine

个人简介

HONOURS & AWARDS Singapore National Day Award 2013 Public Administration (Bronze) Faculty Outstanding Researcher Award 2007 Awarded the Excellent Teacher Award (Top 100) AY 2003/2004 of NUS. Awarded Faculty Teaching Excellence Award AY 2003/2004 in Faculty of Medicine of NUS. Awarded Faculty Teaching Excellence Award AY 2003/2004 in Faculty of Science of NUS. Awarded the Excellent Teacher Award (Top 100) AY 2002/2003 of NUS. Awarded Faculty Teaching Excellence Award AY 2004/2005 in Faculty of Science of NUS JSPS Fellowship at RIKEN Institute, Japan 2001 and 2010 Commonwealth Medical Fellowship at Oxford University (1993-1994)

研究领域

The theme of my research is on the biology of cancers, in particular the utility of biological markers of malignancy. Histopathological examination is currently still the gold standard for cancer diagnosis. However, biological markers are playing an increasingly important role in cancer management. Understanding the biological profiles of a cancer would better define its natural and clinical history, and consequently, the likely course of the disease. In this regard, a major focus of my group is to investigate biological markers as prognostication factors and in the prediction of survival and response to therapy. Better characterization of individual patient’s prognosis could aid in clinical management and enable insightful personal decision-making. Drug design based on tumor biology and molecular-targeted cancer therapy. Nanotoxicology and emerging pollutants

近期论文

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Iravani O, Yip GW, Thike AA, Chua PJ, Jane Scully O, Tan PH, Bay BH. Prognostic significance of Claudin 12 in estrogen receptor-negative breast cancer. J Clin Pathol. 2016 Feb 29. E Pub ahead of print. Shyamasundar S, Dheen ST, Bay BH. Histone Modifications as Molecular Targets in nasopharyngeal Cancer. Curr Med Chem. 2016;23(2):186-97. Sinha RA, Singh BK, Zhou J, Wu Y, Farah BL, Ohba K, Lesmana R, Gooding J, Bay BH, Yen PM. Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling. Autophagy. 2015;11(8):1341-57 Shyamasundar S, Ng CT, Yung LY, Dheen ST, Bay BH. Epigenetic mechanisms in nanomaterial-induced toxicity. Epigenomics. 2015;7(3):395-411 Cheng CL, Thike AA, Tan SY, Chua PJ, Bay BH, Tan PH. Expression of FGFR1 is an independent prognostic factor in triple-negative breast cancer. Breast Cancer Res Treat. 2015 May;151(1):99-111. Cheong JK, Zhang F, Chua PJ, Bay BH, Thorburn A, Virshup DM. Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. J Clin Invest. 2015 Apr;125(4):1401-18 Liu XL, Yang Y, Ng CT, Zhao LY, Zhang Y, Bay BH, Fan HM, Ding J. Magnetic vortex nanorings: a new class of hyperthermia agent for highly efficient in vivo regression of tumors. Adv Mater. 2015 Mar 18;27(11):1939-44 Ng CT, Yung LY, Swa HL, Poh RW, Gunaratne J, Bay BH. Altered protein expression profile associated with phenotypic changes in lung fibroblasts co-cultured with gold nanoparticle-treated small airway epithelial cells. Biomaterials. 2015 Jan;39:31-8 Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y, Ilkayeva OR, Gooding J, Ching J, Zhou J, Martinez L, Xie S, Bay BH, Summers SA, Newgard CB, Yen PM. Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. Hepatology. 2014 Apr;59(4):1366-80. Iravani O, Tay BW, Chua PJ, Yip GW, Bay BH. Claudins and gastric carcinogenesis. Exp Biol Med (Maywood). 2013 Apr;238(4):344-9 Review. Ong C, Lim JZ, Ng CT, Li JJ, Yung LY, Bay BH. Silver nanoparticles in cancer: therapeutic efficacy and toxicity. Curr Med Chem. 2013 Feb 1;20(6):772-81. Huang SM, Zuo X, Li JJ, Li SF, Bay BH, Ong CN. Metabolomics studies show dose-dependent toxicity induced by SiO(2) nanoparticles in MRC-5 human fetal lung fibroblasts. Adv Healthc Mater. 2012 Nov;1(6):779-84. 16. Scully OJ, Bay BH, Yip G, Yu Y. Breast cancer metastasis. Cancer Genomics Proteomics. 2012 Sep-Oct;9(5):311-20. Review. Teng YH, Tan WJ, Thike AA, Cheok TY, Tse GM, Wong NS, Yip GW, Bay BH, Tan PH. Mutations in the epidermal growth factor receptor (EGFR) gene in triple negative breast cancer: possible implications for targeted therapy. Breast Cancer Res. 2011 Apr 1;13(2):R35 Fan HM, Olivo M, Shuter B, Yi JB, Bhuvaneswari R, Tan HR, Xing GC, Ng CT, Liu L, Lucky SS, Bay BH, Ding J. Quantum dot capped magnetite nanorings as high performance nanoprobe for multiphoton fluorescence and magnetic resonance imaging. J Am Chem Soc. 2010 Oct 27;132(42):14803-11 Lwin ZM, Guo C, Salim A, Yip GW, Chew FT, Nan J, Thike AA, Tan PH, Bay BH. Clinicopathological significance of calreticulin in breast invasive ductal carcinoma. Mod Pathol. 2010 Dec;23(12):1559-66 Toh PP, Li JJ, Yip GW, Lo SL, Guo CH, Phan TT, Bay BH.Modulation of metallothionein isoforms is associated with collagen deposition in proliferating keloid fibroblasts in vitro. Exp Dermatol. 2010 Nov;19(11):987-93 Tay WL, Yip GW, Tan PH, Matsumoto K. Yeo R, Ng TP, Kumar SD, Tsujimoto M, Bay BH. Y-Box-binding protein-1 is a promising predictive marker of radioresistance and chemoradioresistance in nasopharyngeal cancer. Mod Pathol.2009 Feb;22(2):282-90. Du HY, Olivo M, Mahendran R, Huang Q, Shen HM, Ong CN, Bay BH. Hypericin photoactivation triggers down-regulation of matrix metalloproteinase-9 expression in well-differentiated human nasopharyngeal cancer cells. Cell Mol Life Sci. 2007 Apr;64(7-8):979-88