个人简介

Education: PhD - Northwestern University A.B. with College Honors - Knox College

研究领域

Biomolecular Structure and Function/Biological/Inorganic

Dr. Crumbliss is interested in the function, reactivity and control of transition metals in biological systems. A major emphasis is investigations related to the biochemistry of iron. Through application of in vitro and ex vivo biophysical techniques the Crumbliss group is investigating iron trafficking mediated by proteins and low molecular weight iron carriers (siderophores) in bacterial and mammalian cells. This research is relevant to understanding iron bioavailability, oxidative stress, and the relationship between iron and human health and disease. The redox behavior of various native, mutant and engineered hemoglobins is also under investigation with respect to their role in oxidative stress, signaling and cooperative oxygen transport, and potential application as cell free blood substitutes.

近期论文

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Amelioration of Metal-Induced Toxicity in Caenorhabditis elegans: Utility of Chelating Agents in the Bioremediation of Metals J. M. Harrington, W. A. Boyd, M. V. Smith, J. R. Rice, J. H. Freedman and A. L. Crumbliss, Toxicological Sciences, submitted for publication. Synthesis and Redox Characterization of Phosphazene Terpolymers with Pendant Ferrocene Groups D. C. Kraiter,P. Wisian-Neilson, C. Zhang, and A. L. Crumbliss, Macromolecules, submitted for publication. Haptoglobin Alters Oxygenation and Oxidation of Hemoglobin and Decreases Propagation of Peroxide-Induced Oxidative Reactions S. Banerjee, Y. Jia, C. J. Parker Siburt, B. Abraham, F. Wood, C. Bonaventura, R. Henkens and A. L. Crumbliss, A. I. Alayash, Free Radicals in Biology and Medicine, 53, 1317 (2012). Characterization of the Aqueous Iron(III) Chelation Chemistry of a Potential Trojan Horse Antimicrobial Agent: Chelate Structure, Stability and pH Dependent Speciation J. M. Harrington, T. Gootz, M. Flanagan, Manjinder Lall, J. ODonnell, J. Winton, J. Mueller, and A. L. Crumbliss, BioMetals., submitted for publication. Slow Histidine H/D Exchange Protocol for Thermodynamic Analysis of Protein Folding and Stability using Mass Spectrometry D. T. Tran, S. Banerjee, A. I. Alayash, A. L. Crumbliss, and M. C. Fitzgerald, Anal. Chem.,84, 1653 (2012). Evidence of Fe3+ Interaction with the Plug Domain of the Outer Membrane Transferrin Receptor Protein of Neisseria gonorrhoeae: Implications for Fe Transport S. Banerjee,C. J. Parker Siburt, S. Mistry, J. Noto, P. DeArmond, M. C. Fitzgerald, L. A. Lambert, C. N. Cornelissen, and A. L. Crumbliss, Metallomics, 4, 361 (2012). FbpA: A Bacterial Transferrin With More to Offer C. J. Parker Siburt, T. A. Mietzner, and A. L. Crumbliss, Biochim. Biophys. Acta  General Subjects Special Issue on the Transferrins, 1820, 379 (2012). (invited) Steric Factors Moderate Conformational Fluidity and Contribute to the High Proton Sensitivity of Root Effect Hemoglobins C. J. Bonaventura, R. Henkens, J. Friedman, C. J. Parker Siburt, D. Kraiter, and A. L. Crumbliss, Biochim. Biophys. Acta  Proteins and Proteomics, 1814, 1261 (2011). Iron Transport in Living Cells A. L. Crumbliss and C. J. Parker Siburt in Ionic Interactions in Natural and Synthetic Macromolecules, A. Ciferri and A. Perico, Eds., Wiley & Sons, NY, Chapter 13, accepted for publication (2012). (invited) Fe(III)-complexes of the tripodal trishydroxamate basidiochrome: Potential biological implications J. M. Harrington, G. Winkelmann, K. Haselwandter, and A. L. Crumbliss, J. Inorg. Biochem, 105, 1670 (2011). Characterization of iron(III) sequestration by an analog of the cytotoxic siderophore brasilibactin A: Implications for the iron transport mechanism in mycobacteria J. M. Harrington, H.Park, Y. Ying, J. Hong, and A. L. Crumbliss, Metallomics, 3, 464 (2011). (cover feature article) Design, Synthesis and Study of a Mycobactin-artemisinin Conjugate that has Selective and Potent Activity Against Tuberculosis and Malaria M. J. Miller, A. J. Walz, H. Zhu, C. Wu, G. Moraski, U. M?llmann, E. M. Tristani,A. L. Crumbliss, M. T. Ferdig, L. Checkley, R. L. Edwards and H. I. Boshoff, J. Amer. Chem.Soc., 133, 2076 (2011). (Featured in ??Spotlight?? section of ACS Chem. Biol., 6, 297 (2011).) ??Siderophore-Redox Active Ionophore Host-Guest Assemblies: A Prototype for Selective Metal Ion Compartmentalization?? E. M. Tristani, J. I. Wirgau, G. R. Dubay, J. W. Sibert, A. L. Crumbliss, Inorg. Chim. Acta, 363, 3611 (2010). ??Role of Citrate and Phosphate Anions in the Mechanism of Iron(III) Sequestration by Ferric Bin