黄湧 - 香港科技大学

个人简介

EDUCATION 1993-1997, B.S.,Peking University, Department of Chemistry 1997-2002, M.S., Ph.D.,The University of Chicago, Advisor: Viresh H. Rawal WORKING EXPERIENCES 2002-2004, Postdoctoral Scholar, California Institute of Technology, Advisor: David W. C. MacMillan 2004-2009, Merck & Co., Senior Research Scientist 2009-2015, Peking University, Shenzhen Graduate School, Principal Investigator (Pengcheng Professor) 2015-2019, Peking University, Shenzhen Graduate School, Principal Investigator (tenured Professor) 2019-2022, The University of Science and Technology, Associate Professor 2022-present, The University of Science and Technology, Professor HONORS AND AWARDS The National Science Fund for Distinguished Young Scholars, 2018 Asia Core Program Lectureship Award (by Japan), 2018 The first prize of natural science of Shenzhen Municipality, 2018 Asia Core Program Lectureship Award (by Singapore), 2015 Roche Chinese Young Investigator Award, 2014 ACS and Organic Letters “Outstanding Author of the Year”, 2014 Bayer Investigator Award, 2014 New Century Excellent Talents in University, MOE, China, 2013

研究领域

The Huang group is focused on the development of highly selective catalytic transformations. We are particularly interested in reactions involving a well-defined transient reaction intermediate. How to control the reactivity and selectivity of these highly reactive species is intriguing. The discovery of hidden reactivity and alternative strategies to control selectivity offer endless opportunities for synthetic innovation. With this main theme in place, we strive to develop state-of-the-art synthetic technologies that will find immediate applications in natural products synthesis, medicinal chemistry, and chemical biology.

近期论文

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A Carbene Relay Strategy for Cascade Insertion Reactions Li Li, Chenggang Mi, Guanwang Huang, Meirong Huang, Yuyi Zhu, Shao-Fei Ni, Zhaofeng Wang,* Yong Huang* Angew. Chem. Int. Ed. 2023, e202312793 Enantioselective SN2 Alkylation of Homoenolates by N-Heterocyclic Carbene Catalysis En Li, Kai Tang, Zhuhui Ren, Xiaoyun Liao, Qianchen Liu, Yong Huang,* Jiean Chen* Adv. Sci. 2023, 2303517 Incorporating Domain Knowledge and Structure-Based Descriptors for Machine Learning: A Case Study of Pd-Catalyzed Sonogashira Reactions Kalok Chan, Long Thanh Ta, Yong Huang,* Haibin Su,* Zhenyang Lin* Molecules 2023, 28, 4730 Photoredox Cleavage of a Csp3–Csp3 Bond in Aromatic Hydrocarbons Ke Liao, Cho Ying Chan, Siqi Liu, Xinhao Zhang, Jiean Chen*, Yong Huang*J. Am. Chem. Soc. 2023, 145, ASAP Recent Advances in Ynenamine Chemistry BingyangHan, ZhaofengWang,* YongHuang*Chem. Rec. 2023, 23, e202300099 (Invited Account) Hierarchical graph learning for protein–protein interaction Ziqi Gao, Chenran Jiang, Jiawen Zhang, Xiaosen Jiang, Lanqing Li, Peilin Zhao, Huanming Yang, Yong Huang,* Jia Li* Nat. Commun. 2023, 14, 1093. Synthesis of I(III)/S(VI) reagents and their reactivity in photochemical cycloaddition reactions with unsaturated bonds Li Li, Kun Deng, Yajie Xing, Cheng Ma, Shao-Fei Ni, Zhaofeng Wang,* Yong Huang* Nat. Commun. 2022, 13, 6588. A Thioether-Catalyzed Cross-Coupling Reaction of Allyl Halides and Arylboronic Acids Jingwei Xu, Zhiqi He, Jiwei Zhang, Jiean Chen,* Yong Huang* Angew. Chem. Int. Ed. 2022, 61, e202211408. An NHC-catalyzed [3+2] cyclization of β-disubstituted enals with benzoyl cyanides Wangsheng Liu, Linrui Zhang, Xiaoyun Liao, Jiean Chen,* Yong Huang* Chem. Commun. 2022, 58, 9742-9745. Catalytic cleavage and functionalization of bulky and inert Csp3–Csp3 bonds via a relayed proton-coupled electron transfer strategy Ke Liao, Fengjin Wu, Jiean Chen,* Yong Huang* Cell Rep. Phys. Sci. 2022, 3, 100763. Enantioselective Seleno-Michael Addition Reactions Catalyzed by a Chiral Bifunctional N-Heterocyclic Carbene with Noncovalent Activation En Li, Jiean Chen,* Yong Huang* Angew. Chem. Int. Ed. 2022, 61, e202202040. Enantioselective synthesis of acyclic monohydrosilanes by steric hindrance assisted C-H silylation Delong Mu, Shuqiong Pan, Xiaoyu Wang, Xiaoyun Liao, Yong Huang*, Jiean Chen* Chem. Commun. 2022, 58, 7388-7391. N-Heterocyclic Carbene-Catalyzed 1,4-Alkylcylation of 1,3-Enynes Yuxing Cai, Jiean Chen,* and Yong Huang.* Org. Lett. 2021, 23, 9251-9255. A cross-coupling Reaction between Aliphatic Aldehydes and Sulfonium Salts Baoli Chen, Li Li, Jiean Chen,* and Yong Huang.* Adv. Synth. Catal. 2022, 364, 30-34. N‑Heterocyclic Carbene-Catalyzed Four-Component Reaction: Chemoselective Cradical-Cradical Relay Coupling Involving the Homoenolate Intermediate Zhen Li, Meirong Huang, Xinhao Zhang, Jiean Chen,* and Yong Huang.* ACS catal. 2021, 11, 10123-10130. Synthesis of a-chiral phosphine sufides via no-covalent organocatalysis En Li, Qian Wang, Yuxing Cai, Jiean Chen,* and Yong Huang.* Cell Reports Physical Science. doi:rg/10.1016/j.xcrp.2021.10. A Bifunctional N‑Heterocyclic Carbene as a Noncovalent Organocatalyst for Enantioselective Aza-Michael Addition Reactions Fangfang Guo, Jiean Chen,* and Yong Huang.* ACS catal. 2021, 11, 6316-6324. Photo-induced energy transfer relay of N-heterocyclic carbene catalysis: an asymmetric a-fluorination/isomerization cascade Xinhang Jiang, En Li, Jiean Chen,* and Yong Huang.* Chem. Commun., 2021, 57, 729-732. MolecularInsightsintoSmall-MoleculeDrugDiscovery forSARS-CoV-2 Hailei Su, Feng Zhou, Ziru Huang, Xiaohua Ma, Kathiresan Natarajan, Minchuan Zhang, Yong Huang,* and Haibin Su.* Angew. Chem. Int. Ed. 2021, 60, 9789–9802. Enantioselective Intramolecular [2,3]-Sigmatropic Rearrangement of Aldehydes via a Sulfonium Enamine Intermediate Li Li, Baoli Chen, Jiean Chen,* Yong Huang.* Angew. Chem. Int. Ed. 2020, 59, 20904 –20908. Direct Synthesis of Bicyclic Acetals via Visible Light Catalysis Fengjin Wu, Leifeng Wang, Ying Ji, Ge ou, Hong Shen, David A. Nicewicz,* Jiean Chen,* Yong Huang.* iScience 2020, 23, 10139. Ligand-Controlled C-O Bond Coupling of Carboxylic Acids and Aryl Iodides: Experimental and Computational Insights Li Li, Feifei Song, Xiumei Zhong, Yun-Dong Wu, Xinhao Zhang,* Jiean Chen,* and Yong Huang.* Adv. Synth. Catal. 2020, 362, 126 – 132 Alcohol-Directed ortho-C–H Alkenylation Li Li, Qinglan Liu, Jiean Chen *, Yong Huang *. Synlett 2019, 30, A-E. DOI: 10.1055/s-0037-1611538 Enantio- and Diastereoselective Hydrofluorination of Enals via N-Heterocyclic Carbene Catalysis Leming Wang, Xinhang Jiang, Jiean Chen,* Yong Huang*. Angew. Chem. Int. Ed. 2019. DOI:10.1002/anie.201902989 N‐Heterocyclic Carbenes as Brønsted Base Catalysts Jiean Chen, Yong Huang. Book Author(s): Akkattu T. Biju. DOI :10.1002/9783527809042.ch9 Dehydrogenative Annulation of γ,δ-Unsaturated Amides and Alkynes via Double C-H Activation Wang Zhen, Li En, He Zhiqi, Chen Jiean, Huang Yong. Acta Phys. -Chim. Sin. 2019, 35, 0001–0009. DOI: 10.3866/PKU.WHXB201811038. Switching Reaction Pathways by Cooperative Catalysis of N-Heterocyclic Carbene and Lewis Acids Wang Leming, Wang Qian, Chen Jiean*, Huang Yong*. Acta Chim. Sinica 2018, 76, 850—856. Structure-Based Drug Design and Identification of H2O‑Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo Peichen Pan,† Jiean Chen,§ Xijian Li,§ Miyang Li,§ Huidong Yu,∥ Jean J. Zhao,⊥,# Jing Ni,⊥,#Xuwen Wang,† Huiyong Sun,† Sheng Tian,∇ Feng Zhu,† Feng Liu,∇ Yong Huang,*,§ and Tingjun Hou*,†,‡ J. Med. Chem. 2018, XXX, XXX−XXX. DOI: 10.1021/acs.jmedchem.8b00498 Aerobic Oxidation/Annulation Cascades via Synergistic Catalysis of RuCl3 and N‐Heterocyclic Carbenes Qian Wang, Jiean Chen*, Yong Huang*. Chem. Eur. J. 2018, 24, 12806 – 12810. DOI: 10.1002/chem.201803254 Enantioselective hydroamidation of enals by trapping of a transient acyl species Pengfei Yuan, Jiean Chen*, Jing Zhao*, Yong Huang*. Angew. Chem. Int. Ed. 2018. 57, 8503 –8507. DOI: 10.1002/anie.201803556 A Transition-Metal-Free Suzuki-Type Cross-Coupling Reaction of Benzyl Halides and Boronic Acids via 1,2-Metallate Shift Zhiqi He, Feifei Song, Huan Sun, and Yong Huang*. J. Am. Chem. Soc. 2018, 140, 2693-2699. DOI: 10.1021/jacs.8b00380 Streamlined asymmetric α-difunctionalization of ynones Siyu Peng1, Zhaofeng Wang1, Linxing Zhang, Xinhao Zhang* & Yong Huang*. Nat. Commun. 2018, 9, 375. DOI: 10.1038/s41467-017-02801-9 Enantioselective Cooperative Proton-Transfer Catalysis using Chiral Ammonium Phosphates Linrui Zhang, Pengfei Yuan, Jiean Chen* and Yong Huang*. Chem. Commun., 2018, 54, 1473. DOI: 10.1039/C7CC09549J Direct Synthesis of Polysubstituted Aldehydes via Visible-Light-Catalysis Fengjin Wu1, Leifeng Wang1, Jiean Chen*, David A. Nicewicz*, Yong Huang*. Angew. Chem. Int. Ed. 2018, 57, 2174-2178. DOI: 10.1002/anie.201712384 Iridium-Catalyzed Aerobic α,β-Dehydrogenation of γ,δ-Unsaturated Amides and Acids: Activation of Both α- and β-C–H bonds through an Allyl–Iridium Intermediate Zhen Wang1, Zhiqi He1, Linrui Zhang and Yong Huang*, J. Am. Chem. Soc., 2018, 140, 735−740. DOI: 10.1021/jacs.7b11351