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个人简介

学习经历 1.2000/9–2005/7,北京大学,生物学(生物信息学),博士 2.1991/9–1995/6,吉林大学,数学,学士 工作经历 1.2010-至今,华北理工大学,生命科学学院,教授,院长,硕导 2.2008-至今,华北理工大学,基因组学与计算生物学研究中心,主任 3.2006/2-2009/12,美国乔治亚大学,博士后

研究领域

主要从事生物信息学和基因组学的研究,在多个植物基因组测序的国际合作项目中任生物信息学/比较基因组学分析的首席科学家或研究组组长;作为植物基因组信息学领域著名专家之一,取得了多项突出的独创性成果:生物信息学软件和数据库开发,染色体进化理论创新,基因组多倍化与稳定性研究,重要经济作物全基因组比对算法和应用研究,基因家族和调控网络研究。

项目成果 1.国家自然科学基金面上项目:水稻和高粱基因进化的比较基因组分析(30971611/C060602,2010-2012,32万),主持,已结题。 2.国家自然科学基金面上项目:稻属一对部分同源染色体间的非正常遗传重组研究(31170212/C020303,2012-2015,60万),主持,已结题。 3.国家自然科学基金面上项目:棉花基因组结构与功能的比较基因组学研究(31371282/C060501,2014-2017,70万),主持,在研。 4.主持河北省自然科学基金杰出青年项目:粳稻和籼稻同源染色体间的遗传重组研究(C2013209142,2013-2015,30万),主持,已结题。

近期论文

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1.WangX,GuoH,WangJ,LeiT,LiuT,WangZ,LiY,LeeTH,LiJ,TangH,JinD,PatersonAH.Comparativegenomicde-convolutionofthecottongenomerevealedadecaploidancestorandwidespreadchromosomalfractionation.Newphytologist2016,209(3):1252-1263. 2.XiyinWang,JingpengWang,DianchuanJin,HuiGuo,Tae-HoLee,TaoLiuandAndrewH.Paterson.GenomeAlignmentSpanningMajorPoaceaeLineagesRevealsHeterogeneousEvolutionaryRatesandAltersInferredDatesforKeyEvolutionaryEvents.MolecularPlant2015,8(6):885-898. 3.WangX,WangZ,GuoH,ZhangL,WangL,LiJ,JinD,PatersonAH.Telomere-centricgenomerepatterningdeterminesrecurringchromosomenumberreductionsduringtheevolutionofeukaryotes.NewPhytologist2015,205(1):378-389. 4.DingM,YeW,LinL,HeS,DuX,ChenA,CaoY,QinY,YangF,JiangY,ZhangH,WangX,PatersonAH,RongJ.TheHairlessStemPhenotypeofCotton(Gossypiumbarbadense)IsLinkedtoacopia-LikeRetrotransposonInsertioninhomeodomainleucinezipperGene(HD1).Genetics2015,201(1):143-154. 5.LiC,ZhangY,ZhangK,GuoD,CuiB,WangX,andHuangX.PromotingFlowering,LateralShootOutgrowth,LeafDevelopment,andFlowerAbscissioninTobaccoPlantsOverexpressingCottonFLOWERINGLOCUST(FT)-LikeGeneGhFT1.FrontiersinPlantSciences2015,6:454-454. 6.RatnaparkheMB,LeeTH,TanX,WangX,LiJ,KimC,RainvilleLK,LemkeC,ComptonRO,RobertsonJ,GalloM,BertioliDJ,PatersonAH.Comparativeandevolutionaryanalysisofmajorpeanutallergengenefamilies.GenomeBiolEvol2014,6(9):2468-2488. 7.BoulosChalhoub,FranceDenoeud,Shengyi,Liu,YongmingZhou,IsobelA.P.Parkin,HaibaoTang,XiyinWang*,JulienChiquet,HarryBelcram,ChaoboTong,BirgitsSamans,CorinneDaSilva,MargotCorréa,JérémyJust,…,DaveEdwards,WeiHua†,AndrewG.Sharpe§,AndrewH.Paterson,ChunyunGuan,PatrickWincker.Earlyallopolyploidevolutioninthepost-neolithicBrassicanapusoilseedgenome.Science2014,345(6199):950-953(*XiyinWangisthegroupleaderofcomparativegenomicsresearch)(citation#39) 8.KimC*,WangX*,LeeTH,JakobK,LeeGJ,PatersonAH:ComparativeAnalysisofMiscanthusandSaccharumRevealsaSharedWhole-GenomeDuplicationbutDifferentEvolutionaryFates.PlantCell2014,26(6):2420-2429(co-first-author)(citation#5) 9.ParkinIA,KohC,TangH,RobinsonSJ,KagaleS,ClarkeWE,TownCD,NixonJ,KrishnakumarV,BidwellSL,etal:TranscriptomeandmethylomeprofilingrevealsrelicsofgenomedominanceinthemesopolyploidBrassicaoleracea.GenomeBiol2014,15(6):R77-R77.(citation12) 10.GuoH,WangX,GundlachH,MayerKF,PetersonDG,SchefflerBE,CheePW,PatersonAH:ExtensiveandBiasedIntergenomicNonreciprocalDNAExchangesShapedaNascentPolyploidGenome,Gossypium(Cotton).Genetics2014,197(4):1153-1163.(citation#2) 11.LiuS,LiuY,YangX,TongC,EdwardsD,ParkinIA,ZhaoM,MaJ,YuJ,HuangS,etal:TheBrassicaoleraceagenomerevealstheasymmetricalevolutionofpolyploidgenomes.NatCommun2014,5:3930.(XiyinWangisthePIofcomparativegenomicsresearch)(citation#40) 12.LeeTH,GuoH,WangX,KimC,PatersonAH:SNPhylo:apipelinetoconstructaphylogenetictreefromhugeSNPdata.BMCGenomics2014,15:162.(citation#4) 13.Renny-ByfieldS,GallagherJP,GroverCE,SzadkowskiE,PageJT,UdallJA,WangX,PatersonAH,WendelJF:AncientgeneduplicatesinGossypium(cotton)exhibitnear-completeexpressiondivergence.GenomeBiolEvol2014,6(3):559-571.(citation#5) 14.HeN,ZhangC,QiX,ZhaoS,TaoY,YangG,LeeTH,WangX,CaiQ,LiD,etal:DraftgenomesequenceofthemulberrytreeMorusnotabilis.NatCommun2013,4:2445.(XiyinWangisthePIofcomparativegenomicsresearch)(citation#30) 15.WangZ,ZhangD,WangX,TanX,GuoH,PatersonAH:Awhole-genomeDNAmarkermapforcottonbasedontheD-genomesequenceofGossypiumraimondiiL.G3(Bethesda)2013,3:1759-1767.(citation#14) 16.GuoH,LeeTH,WangX,PatersonAH:Functionrelaxationfollowedbydiversifyingselectionafterwhole-genomeduplicationinfloweringplants.PlantPhysiol2013,162(2):769-778.(citation#18) 17.ZhangD,GuoH,KimC,LeeTH,LiJ,RobertsonJ,WangX,WangZ,PatersonAH:CSGRqtl,acomparativequantitativetraitlocusdatabaseforSaccharinaegrasses.PlantPhysiol2013,161(2):594-599.(citation#6) 18.WangY,WangX,LeeTH,MansoorS,PatersonAH:GenebodymethylationshowsdistinctpatternsassociatedwithdifferentgeneoriginsandduplicationmodesandhasaheterogeneousrelationshipwithgeneexpressioninOryzasativa(rice).NewPhytol2013,198(1):274-283.(citation#11) 19.LeeTH,TangH,WangX,PatersonAH:PGDD:adatabaseofgeneandgenomeduplicationinplants.NucleicAcidsRes2013,41(D1):D1152-1158.(citation#58) 20.PatersonAH,WendelJF,GundlachH,GuoH,JenkinsJ,JinD,LlewellynD,ShowmakerKC,ShuS,UdallJ,etal:RepeatedpolyploidizationofGossypiumgenomesandtheevolutionofspinnablecottonfibres.Nature2012,492(7429):423-427.(XiyinWangisthePIofcomparativegenomicsresearch)(citation#194) 21.TheTomatoGenomeSequencingProjectConsortium.Thegenomesgenomesequenceprovidesinsightsintofleshyfruitevolution.Nature2012,485(7400):635-641.(Wang.X.isaPIandgroupleaderofcomparativegenomicsresearch)(citation#633) 22.WangY,WangX,PatersonAH:Genomeandgeneduplicationsandgeneexpressiondivergence:aviewfromplants.AnnNYAcadSci2012,1256:1-14.(citation#45) 23.WangY,TangH,DebarryJD,TanX,LiJ,WangX,LeeTH,JinH,MarlerB,GuoH,etal:MCScanX:atoolkitfordetectionandevolutionaryanalysisofgenesyntenyandcollinearity.NucleicAcidsRes2012,40(7):e49.(citation#78) 24.JRong,XWang,SRSchulze,ROCompton,TDWilliams-Coplin,VGoff,PWChee,AHPaterson:Types,levelsandpatternsoflow-copyDNAsequencedivergence,andphylogeneticimplications,forGossypiumgenometypes.Heredity2012,108(5):500-506. 25.WangY,WangX,TangH,TanX,FicklinSP,FeltusFA,PatersonAH:Modesofgeneduplicationcontributedifferentlytogeneticnoveltyandredundancy,butshowparallelsacrossdivergentangiosperms.PLoSOne2011,6(12):e28150.(citation#38) 26.WangX,TorresMJ,PierceG,LemkeC,NelsonLK,YukselB,BowersJE,MarlerB,XiaoY,LinL,etal:AphysicalmapofBrassicaoleraceashowscomplexityofchromosomalchangesfollowingrecursivepaleopolyploidizations.BMCGenomics2011,12:470.(citation#10) 27.WangX,WangH,WangJ,SunR,WuJ,LiuS,BaiY,MunJH,BancroftI,ChengF,etal:ThegenomeofthemesopolyploidcropspeciesBrassicarapa.NatGenet2011,43(10):1035-1039.(XiyinWangisthePIofcomparativegenomicsresearch)(citation#557) 28.RatnaparkheMB*,WangX*,LiJ,ComptonRO,RainvilleLK,LemkeC,KimC,TangH,PatersonAH:ComparativeanalysisofpeanutNBS-LRRgeneclusterssuggestsevolutionaryinnovationamongduplicateddomainsanderosionofgenemicrosynteny.NewPhytol2011,192(1):164-178.(co-first-authorship)(citation#17) 29.LinL,TangH,ComptonRO,LemkeC,RainvilleLK,WangX,RongJ,RanaMK,PatersonAH:ComparativeanalysisofGossypiumandVitisgenomesindicatesgenomeduplicationspecifictotheGossypiumlineage.Genomics2011,97(5):313-320.(citation#10) 30.WangX,TangH,PatersonAH:Seventymillionyearsofconcertedevolutionofahomoeologouschromosomepair,inparallel,inmajorPoaceaelineages.PlantCell2011,23(1):27-37.(citation#38) 31.LinL,PierceGJ,BowersJE,EstillJC,ComptonRO,RainvilleLK,KimC,LemkeC,RongJ,TangH,etal:AdraftphysicalmapofaD-genomecottonspecies(Gossypiumraimondii).BMCGenomics2010,11:395.(citation#35) 32.Wang,X.,andPaterson,A.H.GeneconversioninangiospermgenomewithanEmphasisongenesduplicatedbypolyploidization.Genes2011,2(1):1-20(citation#12) 33.PatersonAH,FreelingM,TangH,WangX:Insightsfromthecomparisonofplantgenomesequences.AnnuRevPlantBiol2010,61(1):349-372.(citation#112) 34.TangH,BowersJE,WangX,PatersonAH:Angiospermgenomecomparisonsrevealearlypolyploidyinthemonocotlineage.ProcNatlAcadSciUSA2010,107(1):472-477.(citation#112) 35.WangX,GowikU,TangH,BowersJE,WesthoffP,PatersonAH:ComparativegenomicanalysisofC4photosyntheticpathwayevolutioningrasses.GenomeBiol2009,10(6):R68.(citation#69) 36.WangX,TangH,BowersJE,PatersonAH:Comparativeinferenceofillegitimaterecombinationbetweenriceandsorghumduplicatedgenesproducedbypolyploidization.GenomeRes2009,19(6):1026-1032.(citation#43) 37.PatersonAH,BowersJE,BruggmannR,DubchakI,GrimwoodJ,GundlachH,HabererG,HellstenU,MitrosT,PoliakovA,Wang.X.etal:TheSorghumbicolorgenomeandthediversificationofgrasses.Nature2009,457(7229):551-556.(citation#1267) 38.PatersonAH,BowersJE,FeltusFA,TangH,LinL,WangX:Comparativegenomicsofgrassespromisesabountifulharvest.PlantPhysiol2009,149(1):125-131.(citation#38) 39.LyonsE,PedersenB,KaneJ,AlamM,MingR,TangH,WangX,BowersJ,PatersonA,LischD,FreelingM:FindingandcomparingsyntenicregionsamongArabidopsisandtheoutgroupspapaya,poplar,andgrape:CoGewithrosids.PlantPhysiol2008,148(4):1772-1781.(citation#125) 40.TangH,WangX,BowersJE,MingR,AlamM,PatersonAH:Unravelingancienthexaploidythroughmultiply-alignedangiospermgenemaps.GenomeRes2008,18(12):1944-1954.(citation#218) 41.TangH,BowersJE,WangX,MingR,AlamM,PatersonAH:Syntenyandcollinearityinplantgenomes.Science2008,320(5875):486-488(citation#326) 42.MingR,HouS,FengY,YuQ,Dionne-LaporteA,SawJH,SeninP,WangW,LyBV,LewisKL,etal:Thedraftgenomeofthetransgenictropicalfruittreepapaya(CaricapapayaLinnaeus).Nature2008,452(7190):991-996.(citation#571) 43.WangX,TangH,BowersJE,FeltusFA,PatersonAH:Extensiveconcertedevolutionofriceparalogsandtheroadtoregainingindependence.Genetics2007,177(3):1753-1763.(citation#64) 44.WangX,ShiX,LiZ,ZhuQ,KongL,TangW,GeS,LuoJ:StatisticalinferenceofchromosomalhomologybasedongenecolinearityandapplicationstoArabidopsisandrice.BMCBioinformatics2006,7:447.(citation#55) 45.ShiX*,WangX*,LiZ,ZhuQ,TangW,GeS,LuoJ:Nucleotidesubstitutionpatterninriceparalogues:implicationfornegativecorrelationbetweenthesynonymoussubstitutionrateandcodonusagebias.Gene2006,376(2):199-206.(co-first-authorship)(citation#10) 46.WangX,ShiX,HaoB,GeS,LuoJ:DuplicationandDNAsegmentallossinthericegenome:implicationsfordiploidization.NewPhytol2005,165(3):937-946.(citation#224) 47.YuJ,WangJ,LinW,LiS,LiH,ZhouJ,NiP,DongW,HuS,ZengC,etal:TheGenomesofOryzasativa:ahistoryofduplications.PLoSBiol2005,3(2):e38.(citation#671) 48.WangX,ShiX,HaoB:ThetransferRNAgenesinOryzasativaL.ssp.indica.SciChinaCLifeSci2002,45(5):504-511.(citation#14) 49.ShiX,WangX,LiZ,ZhuQ,YangJ,GeS,LuoJ:EvidencethatnaturalselectionistheprimarycauseoftheGuanine-cytosinecontentvariationinricegenes.JournalofIntegrativePlantBiology2007,49(9):1393-1399.(co-first-authorship)(citation#8) 50.WangX,ShiXL,HaoB:ThetRNAandrRNAgenesintheOryzasativagenome.ActaGeneticsSinica2004,31(9):871-877.(citation#3)

学术兼职

1.国际计算生物学学会会员(ISCB); 2.国际分子进化学会会员(SMBE); 3.美国遗传学会会员(GSA); 4.知名国际学术刊物审稿人《PlantCell》、《MolecularBiologyandEvolution》、《Genetics》、《NewPhytologist》、《DatainBrief》、《JournalofBioinformaticsandComputationalBiology》、《MolecularPlant》、《BMCGenomics》、《BMCresearchnotes》、《BMCplantbiology》、《FrontiersinPlantGenomics》、《FrontiersinBioinformatics》、《PLOSone》等十余个国际知名学术杂志审稿人; 5.学术杂志《AmericanJournalofMolecularBiology》主编(2012,2013); 6.学术杂志《ActaHoriculturaeSinica》编委(2015)

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