董宇辉 - 中国科学院大学 - 核科学与技术学院

个人简介

招生专业 070205-凝聚态物理 071010-生物化学与分子生物学 071011-生物物理学招生方向蛋白质结构和功能，X射线晶体学 DNA损伤修复的结构生物学研究溶液状态蛋白质结构研究教育背景 1990-09--1995-07 中国科学院高能物理研究所理学博士 1986-09--1990-07 中山大学物理系理学学士工作简历 2001-01~现在, 中国科学院高能物理研究所, 研究员 1997-07~2001-01,意大利Trento大学工学院, 博士后，客座研究员 1995-07~1997-07,中国科学院物理研究所, 博士后教授课程 X射线晶体学（近代物理方向）科研实践Ⅱ-前沿物理研究****** 同步辐射应用概论科研实践Ⅰ-综合物理实验****** X射线晶体学结构生物学导论 X射线晶体学（2） X射线晶体学（1） X射线晶体学(2) X射线晶体学(1) 专利与奖励北京市科技进步二等奖科研项目（ 1 ）基于同步辐射的蛋白质和复合体三维结构测定新技术研究, 主持, 国家级, 2009-01--2014-12 （ 2 ）综合同步辐射小角散射和晶体学解析蛋白质复合物结构的方法学研究, 主持, 国家级, 2010-01--2013-12 （ 3 ）与环境和纳米生物效应相关的蛋白质研究平台, 主持, 国家级, 2011-01--2012-01 （ 4 ）蛋白质生命周期过程及调控的分子机制, 参与, 国家级, 2012-01--2016-12 （ 5 ）基于自由电子X射线激光的结构解析技术, 主持, 部委级, 2014-01--2018-12 （ 6 ）蛋白质分拣与转运以及降解的结构生物学研究, 主持, 国家级, 2012-01--2016-12 （ 7 ）依托同步辐射光源的蛋白质晶体学前沿关键技术综合研究, 主持, 国家级, 2017-07--2022-06

研究领域

（1）蛋白质结构解析方法研究；（2）时间分辨蛋白结构研究；（3）X射线生物成像。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

（1） A micro-focusing and high-flux-throughput beamline design using a bending magnet for microscopic XAFS at the High Energy Photon Source, J. Synchrotron Rad., 2019-09, 通讯作者（2） Conformational changes of antitoxin HigA from Escherichia coli str. K-12 upon binding of its cognate toxin HigB reveal a new regulation mechanism in toxin-antitoxin systems, Biochemical and Biophysical Research Communications, 2019-06, 第 6 作者（3） Structural characterization of the Imm52 family protein TsiT in Pseudomonas aeruginosa, Protein Sci., 2019-05, 通讯作者（4） The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function, PLoS Pathog., 2018, 通讯作者（5） Structural and SAXS analysis of Tle5-Tli5 complex reveals a novel inhibition mechanism of H2-T6SS in Pseudomonas aeruginosa, Protein Sci., 2017, 通讯作者（6） Crystal structure of the putative cytoplasmic protein STM0279 (Hcp2) from Salmonella typhimurium, Acta Crystallogr F, 2017, 通讯作者（7） Structural analysis of Wss1 protein from saccharomyces cerevisiae, Sci Rep., 2017, 通讯作者（8） Crystal structure of the putative cytoplasmic protein STM0279 (Hcp2) from Salmonella typhimurium, Acta Crystallogr F Struct Biol Commun., 2017, 通讯作者（9） Structural analysis of Wss1 protein from Saccharomyces cerevisiae, Sci Rep., 2017, 通讯作者（10） Structural insights into the inhibition mechanism of bacterial toxin LsoA by bacteriophage antitoxin Dmd, Mol Microbiol., 2016, 通讯作者（11） Structural characterizations of phage antitoxin Dmd and its interactions with bacterial toxin RnlA, Biochem Biophys Res Commun., 2016, 通讯作者（12） Structural basis for the interaction of BamB with the POTRA3-4 domains of BamA, Acta Crystallogr D, 2016, 通讯作者（13） Structural analysis of Pseudomonas aeruginosa H3-T6SS immunity proteins, FEBS Lett., 2016, 通讯作者（14） Genome-Wide Mapping of the Binding Sites and Structural Analysis of Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 2 Reveal that It Is a DNA-Binding Transcription Factor, J Virol., 2015, 通讯作者（15） Crystal structure of GnsA from Escherichia coli., Biochem Biophys Res Commun., 2015, 通讯作者（16） A multiple-common-lines method to determine the orientation of snapshot diffraction patterns from single particles, Acta Cryst. A, 2014, 通讯作者（17） Structure of the type VI secretion phospholipase effector Tle1 provides insight into its hydrolysis and membrane targeting, Acta Crystallogr D, 2014, 通讯作者（18） Structural and functional analysis show that the Escherichia coli uncharacterized protein YjcS is likely an alkylsulfatase, Protein Sci., 2014, 通讯作者（19） Structural and Functional Characterization of Escherichia coli Toxin-Antitoxin Complex DinJ-YafQ, J Biol. Chem., 2014, 通讯作者（20） Structure of the type VI effector-immunity complex (Tae4-Tai4) provides novel insights into the inhibition mechanism of the effector by its immunity protein, J Biol Chem., 2013, 通讯作者（21） Structure Analysis of the Global Metabolic Regulator Crc from Pseudomonas Aeruginosa, IUBMB Life, 2013, 通讯作者（22） The structural basis of the response regulator DrRRA from Deinococcus radiodurans, Biochem Biophys Res Commun, 2012, 通讯作者（23） Crystal structure of Escherichia coli BamD and its functional implications in outer membrane protein assembly, Acta Cryst. D, 2012, 通讯作者（24） Phase retrieval in protein crystallography, Acta Cryst. A, 2012, 通讯作者（25） The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6, FEBS Letters, 2012, 通讯作者（26） Crystal and solution structures of methyltransferase RsmH provide basis for methylation of C1402 in 16S rRNA, Journal of Structural Biology, 2012, 通讯作者（27） Structural insights into the function of 23S rRNA methyltransferase RlmG (m2G1835) from Escherichia coli, RNA, 2012, 通讯作者（28） Crystal structure of Escherichia coli BamB and its interaction with BamA, Acta Cryst. D, 2012, 通讯作者（29） Insights into the Catalytic Mechanism of 16S rRNA Methyltransferase RsmE (m3U1498) from Crystal and Solution Structures, J. Mol. Biol., 2012, 通讯作者（30） Crystal structure of type VI effector Tse1 from Pseudomonas aeruginosa, FEBS Letters, 2012, 通讯作者（31） Structural and SAXS analysis of the budding yeast SHU-complex proteins, FEBS letters, 2012, 通讯作者（32） The 1.6A resolution structure of activated D138L mutant of catabolite gene activator protein with two cAMP bound in each monomer, Int. J. Biol. Macromol., 2011, 通讯作者（33） A high-resolution and new form crystal structure of BamA POTRA4-5 from Escherichia coli, Acta Cryst. F, 2011, 通讯作者（34） Crystal structure and site-directed mutagenesis of a nitroalkane oxidase from Streptomyces ansochromogenes, Biochemical and Biophysical Research Communications, 2011, 通讯作者（35） Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans, Acta Cryst. F, 2011, 通讯作者（36） Exploring Intertrimer Cu...Cu Interactions and Further Phosphorescent Properties of Aryl Trimer Copper(I) Pyrazolates via Substituent Changing and External Pressure, Inorg. Chem., 2010, 通讯作者（37） Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans, Acta Cryst. F, 2010, 通讯作者（38） Effect of metal ion on the structure and function of LiPDF: The study of the fine structure around the metal site using XANES, Nuclear Instruments and Methods in Physics Research A, 2010, 通讯作者（39） Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans, Cell Research, 2010, 通讯作者