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个人简介

Prof. Shu-Li You was born in 1975 in Luohe, Henan province, China, and received his BSc in chemistry from Nankai University in 1996. He obtained his PhD from the Shanghai Institute of Organic Chemistry (SIOC) in 2001 under the supervision of Prof. Li-Xin Dai before doing postdoctoral studies with Prof. Jeffery W. Kelly at The Scripps Research Institute. From 2004, he worked at the Genomics Institute of the Novartis Research Foundation as a Principal Investigator before returning to SIOC in 2006 as a Full Professor. During Jan. 2017 to Mar. 2023, he served as the Director of the State Key Laboratory of Organometallic Chemistry. Since 2019, he has been appointed as the Deputy Director of SIOC. His current research interests include asymmetric catalysis, synthetic methodology, natural product synthesis, as well as medicinal chemistry. Prof. Shu-Li You has published over 360 peer-reviewed papers and edited two books, and applied over 30 Chinese patents as a co-inventor. Dr. You’s papers have received total citations over 26000 and his h-index is 90 (until August 2023). He is the recipient of AstraZeneca Excellence in Chemistry Award (2011), RSC Merck Award (2015), Ho Leung Ho Lee Foundation Prize for Scientific and Technological Innovation (2016), China Youth Science and Technology Award (2016), Novartis Chemistry Lectureship (2017/2018), National Natural Science Award (2nd class) (2017), Xplorer Prize (2019), and New Cornerstone Investigator Program (2023). Education and Research Experience: Nov. 2019-present: Deputy Director, Shanghai Institute of Organic Chemistry, Shanghai, China Jan. 2017-Mar. 2023: Director, State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai, China Apr. 2006-Present: Professor, State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai, China Feb. 2004-Apr. 2006: Principal Investigator, Genomics Institute of the Novartis Research Foundation, San Diego, CA USA Sept. 2001-Feb. 2004: Postdoctoral fellow, (advisor: Professor Jeffery W. Kelly), Department of Chemistry, The Scripps Research Institute, La Jolla, CA USA Sept. 1996-July 2001: Graduate student (advisor: Professor Li-Xin Dai), Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China Professional service Associate Editor, Journal of the American Chemical Society, 2021.1.1- Associate Editor, Chemical Science, 2020.7.1- Associate Editor, Organometallics, 2014.12.1-2019.12.31 Associate Editor, Chinese Journal of Organic Chemistry, 2017.1.1- Associate Editor, Beilstein Journal of Organic Chemistry, 2013.1.1-2014.12.30 Editorial Board, Asian Journal of Organic Chemistry, 2012.7- Advisory Board, Chemical Society Reviews, 2011.1.1- Advisory Board, Organic & Biomolecular Chemistry, 2011.1.1- Advisory Board, Chemical Communications, 2012.9- Advisory Board, ACS Catalysis, 2013.11- Advisory Board, Advanced Synthesis & Catalysis, 2014.1- Advisory Board, Chinese Chemical Letters, 2015.10- Advisory Board, Acta Chimica Sinica, 2015.7- Series Editor, Topics in Current Chemistry, 2015.4- Regional Editor, Current Organocatalysis, 2014.6.1- Deputy Director, The Chinese Youth Chemical Society, 2014.1- Fellow of the Royal Society of Chemistry, 2014.3- International Advisory Board (IAB), International Symposium on Homogeneous Catalysis, 2016.3-

研究领域

Catalytic Asymmeric Dearomatization Catalytic Asymmeric C-H Functionalization Development of New Chiral Ligand and Catalysts

近期论文

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Enantioselective Synthesis of Cyclobutane Derivatives via Cascade Asymmetric Allylic Etherification/[2+2] Photocycloaddition.Yang, P.-S.; Wang, R.-X.; Huang, X.-L.; Cheng, Y.-Z.; You, S.-L.* J. Am. Chem. Soc. 2023, DOI: 10.1021/jacs.3c08792. Enantioselective Rh(I)-Catalyzed C-H Arylation of Ferroceneformaldehydes.Liu, C.-X.; Zhao, F.; Gu, Q.; You, S.-L.* ACS Cent. Sci. 2023, DOI: 10.1021/acscentsci.3c00748.(Liu, C.-X. and Zhao, F. Contribute equally) Rhodium-Catalyzed Asymmetric C-H Functionalization Reactions.Liu, C.-X.; Yin, S.-Y.; Zhao, F.; Yang, H.; Feng, Z.; Gu, Q.; You, S.-L.* Chem. Rev. 2023, 123, 16, 10079–10134. (Liu, C.-X. and Yin, S.-Y. Contribute equally) Rhodium(III)-Catalyzed Atroposelective C-H Indolylization of 1-Aryl Isoquinolines with 3-Indolylphenyliodonium Salts. Zheng, D.-S.; Zheng, J.; Wang, Q.; Gu, Q.*; You, S.-L.* Chin. J. Chem. 2023, 41, 2684-2690.? Synthesis of Hexamethyl-1,1-spirobiindane-Based Chiral Spiro Cp Ligands and Their Application in Rhodium-Catalyzed Enantioselective Aryl C-H Addition to Nitroalkenes Yang, H.; Zhang, R.; Zhang, S.-Z.; Gu, Q.; You, S.-L.* ACS. Catal. 2023, 13, 8838-8844. Rhodium-catalyzed enantioselective annulation of N-phenoxyacetamides with 1,3-dienes Yang, H.; Yang, Z.-Q.; Zhang, S.-Z.; Zhang, W.-W.; Gu, Q.; You, S.-L.* Sci China Chem 2023, 66, DOI: 10.1007/s11426-023-1637-8. Rhodium-Catalyzed Enantioselective Spiroannulation of 2-Alkenylphenols with Alkynes Zhang, S.-Z.; Zhang, W.-W.; Yang, H.; Gu, Q.;* You, S.-L.* Chin. J. Org. Chem. 2023, DOI: 10.6023/cjoc202303021. Enantioselective Synthesis of N-N Biaryl Atropisomers through Iridium(I)-Catalyzed C-H Alkylation with Acrylates Yin, S.-Y; Zhou, Q.; Liu, C.-X.; Gu, Q.; You, S.-L.* Angew. Chem., Int. Ed. 2023, e202305067. Asymmetric Dearomatization of Indoles with Azodicarboxylates via Cascade Electrophilic Amination/Aza-Prins Cyclization/Phenonium-like Rearrangement Huang, X.-Y.; Xie, P.-P.; Zou, L.-M.; Zheng, C.*; You, S.-L.* J. Am. Chem. Soc. 2023, 145, 11745-11753. Enantioselective Dearomatization of Indoles via SmI2-Mediated Intermolecular Reductive Coupling with Ketones Zhang, W.-Y.; Wang, H.-C.;Ye Wang, Y.; Zheng, C.*; You, S.-L.* J. Am. Chem. Soc. DOI: 10.1021/jacs.3c01994 Pd-Catalyzed intermolecular asymmetricallylic dearomatization of 1-nitro-2-naphthols with MBH adducts Zhang, Q.-X,; Xie, J.-H.; Gu, Q.; You, S.-L.*Chem. Commun., 2023, 59, 3590-3593. Cobalt(III)-catalyzed asymmetricring-opening of 7-oxabenzonorbornadienes via indole C–H functionalization Zheng, Y.; Zhang, W.-Y.; Gu, Q.; Zheng, C.; You, S.-L.*Nat. Comm., 2023, 14, 1094. Enantioselective Synthesis of AxiallyChiral 1-Arylisoquinolines by Iridium(I)-Catalyzed Hydroarylation of Alkynes Zhou, Q.; Yin, S.-Y,; Zheng, D.-S.; Wen-Wen Zhang , Zhang, S.-Z.; Gu, Q.*; You, S.-L.*Synlett 2023, 34, A–E. Explicit Mechanism of Rh(I)-Catalyzed Asymmetric C-H Arylation Liu, C.-X.; Xie, P.-P.; Zhao, F.; Wang, Q.; Feng, Z.; Wang, H.; Zheng, C.*; and You, S.-L.*J. Am. Chem. Soc. 2023, 145, 4765-4773. Stereodivergent Construction of 1,3-ChiralCenters via Tandem Asymmetric Conjugate Additionand Allylic Substitution Reaction Xie, J.-H.; Hou, Y.-M.; Feng, Z.; You, S.-L.*Angew. Chem., Int. Ed. 2023, 62, e2022163. (SCp)Rhodium-Catalyzed Asymmetric Satoh–Miura Reaction for Building-up Axial Chirality:Counteranion-Directed Switching of Reaction Pathways Zhang, W.-W.; Wang, Q.; Zhang, S.-Z.; Zheng, C.*; You, S.-L.* Angew. Chem., Int. Ed. 2023, 62, e2022144 Kinetic resolution of planar chiral metallocenes using Rh-catalysed enantioselective C–H arylation Liu, C.-X.; Zhao, F.; Feng, Z.; Wang, Q.; Gu, Q.; You, S.-L.* Nat. Synth. 2023, 2, 49-57. Structurally defined anti-π-allyliridium complexes catalyse Z-retentive asymmetric allylic alkylation of oxindoles Jiang, R.; Zhao, Q.-R.; Zheng, C.*; You, S.-L.* Nat. Catal. 2022, 5, 1089–1097. Palladium(0)-Catalyzed Intermolecular Asymmetric Allylic Dearomatization of Substituted β-Naphthols with Morita–Baylis–Hillman (MBH) Adducts Zhang, Q.-X.; Gu, Q.; You, S.-L.* Org. Lett. 2022, 24, 43, 8031-8035. Iridium-Catalyzed Asymmetric Allylic Benzylation with Photogenerated Hydroxy-o-Quinodimethanes Yang, P.; Wang, R.-X.; Cheng, Y.-Z.; Zheng, C.; You, S.-L.* Angew. Chem., Int. Ed. 2022, e202213520. Enantioselective C-H Functionalization Reactions Enabled by Cobalt Catalysis. Zheng, Y.; Zheng, C.; Gu, Q.; You, S.-L.* Chem Catal. 2022, DOI: 10.1016/j.checat.2022.08.020. Enantioselective Dearomative Cyclization Enabled by Asymmetric Cooperative Gold Catalysis Zhao, K.; Kohnke, P.; Yang, Z.; Cheng, X.; You, S.-L.*; Zhang, L.* Angew. Chem., Int. Ed. 2022, 61, e202207518. Rh(III)-Catalyzed Enantioselective Intermolecular Aryl C-H Bond Addition to Aldehydes Wu, Z.-J.; Wu, Z.; Zhang, W.-W.; Gu, Q.*; You, S.-L.* Chin. J. Chem. 2022, 40, 2780-2784. Condensed Matter Chemistry in Asymmetric Catalysis and Synthesis Jiang, R.; Liu, C.-X.; Yang, P.; You, S.-L.* Prog. Chem. 2022, 34, 1537-1547. Visible-light enabled synthesis of cyclopropanefused indolines via dearomatization of indoles Haung, X.-L.; Cheng, Y.-Z.*; You, S.-L.* Org. Chem. Front., 2022, 9, 5463-5468. Energy-Transfer-Enabled Dearomative Cycloaddition Reactions of Indoles/Pyrroles via Excited-State Aromatics Zhu, M.; Zhang, X.; Zheng, C.; You, S.-L. Acc. Chem. Res. 2022, 55, 2510-2525. Ag2O/squaramide cocatalyzed asymmetric interrupted Barton-Zard reaction of 8-nitroimidazo[1,2-a]pyridines Wan, Q.; Zheng, C.; Yuan, Y.-F.; You, S.-L.* Sci. Bull. 2022, 67, 16, 1688-1695. Iridium-Catalyzed Intermolecular Asymmetric Allylic Amination with Pyridones Tu, H.-F.; Nie, Y.-H.; Zheng, C.; You, S.-L.* Adv. Synth. Catal. 2022, 364, 1-7. SCpRh(III)-catalyzed Enantioselective Synthesis of Atropisomers by C2-Arylation of Indoles with 1-Diazonaphthoquinones. Yin, S.-Y.; Pan, C.; Zhang, W.-W.; Liu, C.-X.; Zhao, F.; Gu, Q.; You, S.-L.* Org. Lett. 2022, 24, 3620-3625. Chiral Bronsted Acid Catalyzed Intramolecular Asymmetric Allylic Alkylation of Indoles with Primary Alcohols. Zou, L.-M.; Huang, X.-Y.; Zheng, C.; Cheng, Y.-Z.*; You, S.-L.* Org. Lett. 2022, 24, 3544-3548. Enantioselective Synthesis of Medium-sized-ring Lactones via Iridium-catalyzed Z-Retentive Asymmetric Allylic Substitution Reaction. Ding, L.; Song, H.; Zheng, C.; You, S.-L.* J. Am. Chem. Soc. 2022, 144, 4770-4775. Hyper-crosslinked Porous Chiral Phosphoric Acids: Robust Solid Organocatalysts for Asymmetric Dearomatization Reactions. Huang, X.-Y.; Zheng, Q.; Zou, L.-M.; Gu, Q.*; Tu, T.*; You, S.-L.* ACS Catal. 2022, 12, 4545-4553. Pd-Catalyzed Asymmetric Dearomative Arylation of Indoles via a Desymmetrization Strategy Nie, Y.-H.; Komatsuda, M.; Yang, P.; Zheng, C.; Yamaguchi, J.*; You, S.-L.* Org. Lett. 2022, 24, 1481-1485. Palladium-Catalyzed Dearomative Alkoxyallylation of 3-Nitroindoles with Allyl Carbonates. Liu, X.-J.; Zhang, W.-Y.; Zheng, C.; You, S.-L.* Angew. Chem. Int. Ed. 2022, 61, e2022001. Rhodium(III)-Catalyzed Enantioselective C–H Activation/Annulation of Ferrocenecarboxamides with Internal Alkynes. Wang, Q.; Nie, Y.-H.; Liu, C.-X.; Zhang, W.-W.; Wu, Z.-J.; Gu, Q.; Zheng, C.*; You, S.-L.* ACS Catal. 2022, 12, 3083-3093. Multicomponent Reactions and Photo/Electrochemistry Join Forces: Atom Economy Meets Energy Efficiency. Coppola, G. A.; Pillitteri, S.; Van der Eycken, E. V.*; You, S.-L.*; Sharma, U. K.* Chem. Soc. Rev. 2022, 51, 2313-2382. SmI2-mediated enantioselective reductive dearomatization of non-activated arenes. Wang, Y.; Zhang, W.-Y.; Yu, Z.-L.; Zheng, C.; You, S.-L.* Nature Synthesis 2022, 1, 401-406. Visible-Light Induced Dearomatization Reactions. Cheng, Y.-Z.; Feng, Z.; Zhang, X.*; You, S.-L.* Chem. Soc. Rev. 2022, 51, 2145-2170. Rhodium-Catalyzed Atroposelective C-H/C-H Cross-Coupling Reaction between 1-Aryl Isoquinoline Derivatives and Indolizines. Zhang, W.-W.; Liu, C.-X.; Yang, P.; Zhang, S.-Z.; Gu, Q.; You, S.-L.* Org. Lett. 2022, 24, 564-569. Enantioselective Dearomative Mizoroki–Heck Reaction of Naphthalenes. Han, X.-Q.; Wang, L.; Yang, P.; Liu, J.-Y.; Xu, W.-Y.; Zheng, C.; Liang, R.-X.; You, S.-L.*; Zhang, J.*; Jia, Y.-X.* ACS Catal. 2022, 12, 655-661. Enantioselective construction of a congested quaternary stereogenic center in isoindolinones bearing three aryl groups via an organocatalytic formal Betti reaction. Berisa, A.; Glavac, D.; Zheng, C.; You, S.-L.*; Gredicak, M.* Org. Chem. Front. 2022, 9, 428-435. Cascade Asymmetric Dearomative Cyclization Reactions via Transition-metal-catalysis. Liu, Y.-Z.; Song, H.; Zheng, C.*; You, S.-L.* Nature Synthesis 2022, 1, 203-216. (Invited review) Pd-catalyzed Asymmetric Oxidative C-H/C-H Cross-Coupling Reaction between Dialkylaminomethylferrocenesand Indolizines. Liu, C.-X.; Zhang, W.-W.; Yang, P.; Zhao, F.; Feng, Z.; Wang, Q.; Zhang, S.-Z.; Gu, Q.; You, S.-L.* Chem Catal. 2022, 2, 102-113. Electrochemical Rhodium-Catalyzed Enantioselective C-H Annulation with Alkynes. Huang, Y.-Q.; Wu, Z.-J.; Zhu, L.; Gu, Q.; Lu, X.*; You, S.-L.*; Mei, T.-S.* CCS Chem. 2021, 3, 3501-3509. Dearomatization Reaction of β-Naphthols with Disulfurating Reagents. Zhang, S.-S.; Xue, J.; Gu, Q.; Jiang, X.*; You, S.-L.* Org. Biomol. Chem. 2021, 19, 8761-8771. Synthesis of Atropisomers by Transition-Metal-Catalyzed Asymmetric C-H Functionalization Reactions. Liu, C.-X.; Zhang, W.-W.; Yin, S.-Y.; Gu, Q.; You, S.-L.* J. Am. Chem. Soc. 2021, 143, 14025-14040. Ir-catalyzed Sequential Asymmetric Allylic Substitution/Olefin Isomerization for the Synthesis of Axially Chiral Compounds. Zhao, Q.-R.; Jiang, R.; You, S.-L.* Acta Chim. Sinica 2021, 79, 1107-1112. Visible-Light-Induced Dearomatization of Indoles/Pyrroles with Vinylcyclopropanes: Expedient Synthesis of Structurally Diverse Polycyclic Indolines/Pyrrolines. Zhu, M.; Huang, X.-L.; Sun, S.; Zheng, C.*; You, S.-L.* J. Am. Chem. Soc. 2021, 143, 13441-13449. CpxM(III)-Catalyzed Enantioselective C–H Functionalization through Migratory Insertion of Metal-Carbenes/Nitrenes. Pan, C.; Yin, S.-Y.; Gu, Q.; You, S.-L.* Org. Biomol. Chem. 2021, 19, 7264-7275. Palladium-Catalyzed Dearomative Alkoxyallylation of 3-Nitroindoles with Allyl Carbonates. Xie, J.-H.; Zheng, C.; You, S.-L.* Angew. Chem. Int. Ed. 2021, 60, 22184-22188. Ag-Catalyzed Asymmetric Dearomatization of Electron-Deficient Heteroarenes via Interrupted Barton-Zard Reaction. Wan, Q.; Xie, J.-H.; Zheng, C.; Yuan, Y.-F.*; You, S.-L.*Angew. Chem. Int. Ed. 2021, 60, 19730-19734. Ir-Catalyzed Enantioselective Friedel-Crafts Type Allylic Substitution of Indolizines. Yang, P.; Liu, C.-X.; Zhang, W.-W.; You, S.-L.*Acta Chim. Sinica 2021, 79, 742-746. SCpRh(III)-Catalyzed Enantioselective Aryl C-H Addition to Nitroalkenes. Wu, Z.-J.; Zhang, R.; Gu, Q.*; You, S.-L.* Asian J. Org. Chem. 2021, 10, 1722-1725. Enantioselective Synthesis of Polycyclic Pyrrole Derivatives by Iridium-Catalyzed Asymmetric Allylic Dearomatization and Ring-Expansive Migration Reactions. Huang, L.; Xie, J.-H.; Cai, Y.; Zheng, C.*; Hou, X.-L.; Dai, L.-X.; You, S.-L.*Chem. Commun. 2021, 57, 5390-5393. Oxygen-Linked Cyclopentadienyl Rhodium(III) Complexes-Catalyzed Asymmetric C-H Arylation of Benzo[h]quinolines with 1-Diazonaphthoquinones. Pan, C.; Yin, S.-Y.; Wang, S.-B.; Gu, Q.; You, S.-L.* Angew. Chem. Int. Ed. 2021, 60, 15510-15516. Advances in Catalytic Asymmetric Dearomatization. Zheng, C.; You, S.-L.* ACS Cent. Sci. 2021, 7, 432-444. Oxidative Indole Dearomatization for Asymmetric Furoindoline Synthesis by a Flavin-Dependent Monooxygenase Involved in the Biosynthesis of Bicyclic Thiopeptide Thiostrepton Lin, Z.; Xue, Y.; Liang, X.; Wang, J.; Lin, S.; Tao, J.; You, S.-L.*; Liu, W.* Angew. Chem. Int. Ed. 2021, 60, 8401-8405. Iridium-Catalyzed Z-Retentive Asymmetric Allylic Substitution Reactions. Jiang, R.; Ding, L.; Zheng, C.; You, S.-L.* Science 2021, 371, 380-386. Visible-Light-Induced Intramolecular Double Dearomative Cycloaddition of Arenes Zhu, M.; Xu, H.; Zhang, X.*; Zheng, C.*; You, S.-L.* Angew. Chem. Int. Ed. 2021, 60, 7036-7040. Chiral CpxRh Complexes for C–H Functionalization Reactions. Wang, Q.; Liu, C.-X.; Gu, Q.; You, S.-L.* Sci. Bull. 2021, 66, 210-213. Enantioselective Synthesis of Azoniahelicenes by Rh-Catalyzed C-H Annulation with Alkynes. Wang, Q.; Zhang, W.-W.; Zheng, C.; Gu, Q.; You, S.-L.* J. Am. Chem. Soc. 2021, 143, 114-120. Silica Gel-Promoted Synthesis of Multisubstituted Spiroindolenines from Tryptamines and γ-Chloro-α,β-unsaturated Ketones. Liu, Q.-Q.; Zheng, C.*; You, S.-L.* Tetrahedron. 2021, 77, 131765. Recent Advances on Enantioselective Direct C-H Addition to Carbonyls and Michael Acceptors. Gu, Q.*; Wu, Z.-J.; You, S.-L.*Bull. Chem. Soc. Jpn. 2021, 94, 641-647. Enantioselective Synthesis of 4-Silyl-1,2,3,4-tetrahydroquinolines via Copper(I) Hydride Catalyzed Asymmetric Hydrosilylation of 1,2-dihydroquinolines. Xu-Xu, Q.-F.; Yang, P.; Zhang, X.; You, S.-L.*Synlett. 2021, 32, 505-510. (Invited submission to a Special Issue dedicated to Prof. Barry M. Trost)

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