Gilbertson, Scott - Rice University - Department of Chemistry

个人简介

Ph.D., University of Chicago, 1988 M.S., University of Michigan, 1982 B.S., University of Wisconsin-LaCrosse, 1979

研究领域

Our research is centered on the development of new synthetic methods and the utilization of synthetic chemistry for the study of important biological and medical problems. The projects in our laboratory range from the development of new methods in organic synthesis and the total synthesis of biologically important natural products to medicinal chemistry around leads compounds.

近期论文

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"Synthesis and evaluation of dimeric derivatives of 5-HT2A receptor (5-HT2AR) antagonist M-100907," Matthew J. Shashack, Kathryn A. Cunningham, Patricia K. Seitz, Andrew McGinnis, Thressa D. Smith, Cheryl S. Watson and Scott R. Gilbertson,* ACS Chemical Neuroscience, 2, 0000, (2011). "Design, synthesis and diversification of 3,5-substituted enone library," Juhienah Khalaf, Maria E. Estrella-Jimenez, Matthew J. Shashack, Sharangdhar S. Phatak, Shuxing Zhang, and Scott R. Gilbertson* ACS Combinatorial Science, 13, 351, (2011). "Selective serotonin 5-HT2C receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues," Kathryn A. Cunningham*, Robert G. Fox, Noelle C. Anastasio, Marcy J. Bubar, Sonja J. Stutz, F. Gerard Moeller, Scott R. Gilbertson, Sharon Rosenzweig-Lipson, Neuropharmacology, 513, (2011). "Pd-NHC Catalyzed Cyclopentannulation of Diazabicyclic Alkenes with ortho-aryl halides," B. A. Bhanu Prasad, Alexander E. Buechele and Scott R. Gilbertson,* Organic Letters, 12, 5422, (2010). "Design, synthesis and diversification of 5,5-dimethyl cyclohexen-1,4-dione library," Eric A. Tanifu and Scott R. Gilbertson,* J. Combi. Chem. 12, 318, (2010). "Testing efficacy and toxicity of adenylyl cyclase inhibitors against enteric pathogens during in vitro and in vivo models of infection," Scott T. Moen, Carla A. Blumentritt, Terry M. Slater, Shilp D. Patel, Christopher B. Tutt, Maria E. Estrella-Jimenez, Jennifer Pawlik, Laurie Sower, Vsevolod L. Popov, Catherine H. Schein, Scott R. Gilbertson, Johnny W. Petersona, Alfredo G. Torres,* Infection and Immunity, 78, 1740, (2010). "The One-Pot Synthesis of Unsymmetrical N-heterocyclic Carbene Ligands From N-(2-iodoethyl)arylamine salts," B. A. Bhanu Prasad and Scott R. Gilbertson,* Organic Lett. 11, 3710, (2009). "Novel Pyridopyrimidine Derivatives as Inhibitors of Stable Toxin a Induced cGMP Synthesis," Eric A. Tanifum, Alexander Y. Kots, Byung-Kwon Choi, Ferid Murad, and Scott R. Gilbertson,* Bioorg. Med. Chem. Lett. 23, 3067, (2009). "Chemical genetic screening of KRAS-based synthetic lethal inhibitors for pancreatic cancer," Zhenyu Ji, Fang C. Mei, Pedro L. Lory, Scott R. Gilbertson, Yijun Chen and Xiaodong Cheng,* Frontiers in Bioscience, 14, 2904-2910, (2009). "Preparation of a library of unsymmetrical ureas based on 8-azabicyclo[3.2.1]octane scaffold," Anton Agarkov and Scott R. Gilbertson,* J. Combi. Chem. 655, (2008). "Novel inhibitors of cyclic nucleotide synthesis: application for treatment of diarrhea," Alexander Y. Kots, Byung-Kwon Choi, Maria E. Estrella-Jimenez, Cirle A. Warren, Scott R. Gilbertson, Richard L. Guerrant and Ferid Murad,* PNAS 105, 8440, (2008). "Synthesis and Screening of Small Molecule Inhibitors of Anthrax Edema Factor," Maria Estrella Jimenez, Kathryn Bush, Jennifer Pawlik, Laurie Sower, Johnny W. Peterson, and Scott R. Gilbertson,* Bioorg. Med. Chem. Lett. 22, 4215, (2008). A review of "Small-Molecule Inhibitors of Protein Geranylgeranyltransferase Type I," Subhasis De and Scott R. Gilbertson,* ChemTracts, 20, 210, (2008). "Plasmodium Food Vacuole Plasmepsins are Activated by Falcipains," Mark E. Drew, Ritu Banerjee, Eric W. Uffman, Scott R. Gilbertson, Philip J. Rosenthal, Daniel E. Goldberg,* J. Biol. Chem. 12870, (2008). "Substrate specificity and screening of the integral membrane protease Pla," Anton Agarkov, Sadhana Chauhan, Pedro J. Lory, Scott R. Gilbertson* and Vladimir L. Motin, Bioorg. Med. Chem. Lett., 427, (2008). "Synthesis and screening of 3-substituted thioxanthen-9-one-10,10 dioxides," Pedro M. J. Lory, Maria E. Estrella-Jimenez, Matthew J. Shashack, Ganesh L. Lokesh, Amarnath Natarajan and Scott R. Gilbertson,* Bioorg. Med. Chem. Lett. 21, 5940, (2007). "Rhodium Catalyzed Synthesis of Eight-Membered Rings," Brenton DeBoef Richard Counts and Scott R. Gilbertson,* J. Org. Chem. 72, 799, (2007). "An expedient route to 3-chlorothioxanthen-9-one-10,10-dioxide and derivation by palladium catalyzed coupling," Pedro M. J. Lory, Anton Agarkov and Scott. R. Gilbertson,* Synlett, 18, 3045, (2006). A review of "The Liebeskind-Srogl cross-coupling reaction and its synthetic application," Pedro Lory and Scott G. Gilbertson,* ChemTracts, 18, 569, (2006).