Wilson, Lon J. - Rice University - Department of Chemistry

个人简介

B.S. (1966) Iowa State University Ph.D. (1971) University of Washington

研究领域

Professor Wilson's research program involves bringing carbon nanotechnology to the fields of biology and medicine. The nanoparticle "building blocks" of this program are fullerenes (C60), endohedral metallofullerenes (M@C60), and ultra-short (20 nm long) single-walled carbon nanotube capsules (US-tubes). Externally, these carbon nanostructures are being chemically derivatized to make them biocompatible and cell-specific through peptide and antibody targeting. Internally, the nanostructures are being loaded with materials of medical interest for diagnostic and therapeutic medicine. Materials of interest include Fe2O3 and Gd3+ ions for magnetic resonance imaging (MRI), I2 molecules for X-ray computed tomography (CT) imaging and alpha-particle radionuclides (Ac3+-225 and At-211) for alpha-radioimmunotherapy of single-cell cancers. Cancer therapies are also being developed that take advantage of superparamagnetic nanostructures, such as Gd3+@US-tubes, that are simultaneously diagnostic (MRI-guided) and therapeutic (magnetic hyperthermia) agents in a single package. All these carbon nanostructures, with their medical cargos, are designed to be among the first intracellular agents, since the future of medicine will involve the early detection of disease at the cellular level when it is most treatable. Nanoengineered materials promise great advances in medicine, and, working with colleagues at various medical centers, our goal is to bring key, high-performance materials to the clinic as soon as possible.

近期论文

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Q. Ma, M. Jebb, M. F. Tweedle, L. J. Wilson, "The Gadonanotubes: Structural Origin of Their High-Performance MRI Contrast Agent Behavior," J. Mater. Chem. B. 2013, 1, 5791-5797. A. M. Dimiev, A. Gizzatov, L. J. Wilson, and J. M. Tour, "Stable aqueous colloidal solutions of intact surfactant-free graphene nanoribbons and related graphitic nanostructures," Chem. Commun. 2013, 49, 2613-2615. M. Raoof, B. T. Cisneros, A. Guven, S. Phounsvath, S. J. Corr, L. J. Wilson, S. A. Curley, "Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields," Biomaterials 2013, 34, 1862-1869. Q. Ma, M. Jebb, M. F. Tweedle and L. J. Wilson, "X-ray absorption spectroscopy study of Gd3+-loaded ultra-short carbon nanotubes," J. Phys. Conf. Ser. 2013, 430, 012085:1-012085:6. F. Huang, Y. Mackeyev, E. Watson, M. A. Cheney, L. J. Wilson and J. Suh, "Evidence for nuclear internalization of biocompatible [60]fullerene," Eur. J. Nanomed. 2013, 5, 51-55. P. J. J. Alvarez, J. Lee, L. J. Wilson, Y. Mackeyev, J. Kim, "Fullerene Compositions and Methods for Photochemical Purification," U. S. Patent Application Publication No. US 2012/0189492 A1, Published July 26, 2012. L. J. Wilson, K. R. Kissell, K. B. Hartman, "Carbon Nanotube Based Imaging Agents," patent application 13/473,120 filed May 23, 2013. S. J. Corr, O. Kuznetsov, M. Raoof, B. T. Cisneros, M. A. Cheney, W. E. Billups, L. J. Wilson and S. A. Curley, "Fabrication and Bio-Characterization of Highly Water-Soluble Sulphonated Graphene Sheets for Cancer Therapy," Q. Ma, M. Jebb, M. F. Tweedle, L. J. Wilson, "The Gadonanotubes: Structural Origin of Their High-Performance MRI Contrast Agent Behavior," J. Mater. Chem. B 2013, 1, 5791-5797. M. L. Matson, C. H. Villa, J. S. Ananta, D. A. Scheinberg, L. J. Wilson, "Encapsulation of Alpha-particle Emitting Actinium,-225 Ions within Carbon Nanotubes," in preparation 2013. J. Brame, Y. Mackeyev, L. J. Wilson, Q. Li, P. Alvarez, "Trading power for efficiency: differential inhibition of photocatalytically generated hydroxyl radicals versus singlet oxygen," in preparation (2013). (Water Research) Y. Mackeyev, M. Raoof, B. Cisneros, N. Koshkina, C. S. Berger, L. J. Wilson, and S. A. Curley, "Toward Paclitaxel-[60]Fullerene Immunoconjugates as Targeted Prodrug against Cancer," Nanosystems: Physics, Chemistry, Mathematics 2014, 1, 1-6. A. Gizzatov, V. Keshishian, A. Guven, A. M. Dimiev, F. Qu, R. Muthupillai, P. Decuzzi, R. G. Bryant, J. M. Tour and L. J. Wilson, "Enhanced MRI Relaxivity of Aquated Gd3+ Ions by Carboxyphenylated Water-dispersed Graphene Nanoribbons," Nanoscale 2014, 6, 3059-3063. DOI: 10.1039C3NR06026H. A. Gizzatov, J. Key, S. Aryal, J. Ananta, A. Cervadoro, A. Palange, M. Fasano, C. Stigliano, M. Zhong, D. Di Mascolo, A. Guven, E. Chiavazzo, P. Asinari, X. Liu, M. Ferrari, L. J. Wilson, P. Decuzzi, "Hierarchically-Structured Magnetic Nanoconstructs with Enhanced Relaxivity and Cooperative Tumor Accumulation," Adv. Funct. Mater. 2014, 24 (29), 4584-4594. B. T. Cisneros, J. J. Law, M. L. Matson, A. Azhdarinia, E. M. Sevick-Muraca and L. J. Wilson, "Stable Confinement of Positron Emission Tomography and Magnetic Resonance Agents within Carbon Nanotube Capsules for Biomodal Imaging," Nanomedicine 2014, 9 (16) 2499-2509. S. J. Corr, M. Raoof, C. Zhu, S. Phounsavath, B. T. Cisneros, W. D. Kaluarachchi, L. J. Wilson, and S. A. Curley, "Gold Nanoparticles and Radiofrequency in Experimental Models for Hepatocellular Carcinoma," Nanomed. Nanotechnol. Biol. Med. 2014, 10 (6) 1121-1130. J. J. Law, A. Guven and L. J. Wilson, "Relaxivity enhancement of aquated Tris (β-diketonate)gadolinium (III) chelates by confinement within ultrashort single-walled carbon nanotubes" Contrast Media Mol. Imaging 2014, 9 (6) 409-412. Y. Choi, Y. Ye, Y. Mackeyev, M. Cho, S. Lee, L. J. Wilson, J. Lee, P. J. J. Alvarez, W. Choi, L. Lee, "C60 Aminofullerene-magnetite Nanocomposite Designed for Efficient Visible Light Photocatalysis and Magnetic Recovery," Carbon, 2014, 69, 92-100. S. J. Corr, S. Shamsudeen, K. Yoko, D. J. Savage, I. M. Meraz, W. Kaluarachchi, D. Kirui, B. T. Cisneros, M. Raoof, J. Rhudy, J. H. Sakamoto, M. Ferrari, L. J. Wilson, H. Summers, P. Rees, S. A. Curley, and R. E. Serda, "A New Imaging Platform for Visualizing Enhanced Macromolecule Perfusion into Tumors using Non-Invasive Radiofrequency Cancer Therapy," 2014, Proc. Nat. Acad. Sci. USA, submitted. A. Gizzatov, C. Stigliano, J. S. Ananta, R. Sethi, R. Xu, A. Guven, M. Ramirez, H. Shen, A. Sood, M. Ferrari, L. J. Wilson, X. Liu, and P. Decuzzi, "Geometrical confinement of Gd(DOTA) molecules within mesoporous sililcon nanoconstructs for MR imaging of cancer," Cancer Letters 2014, 352, 97-101. L. A. Tran, M. Hernandez-Rivera, A. N. Berlin, Y. Zheng, L. Sampaio, C. Bove, M. G. Cabreira-Hansen. J. T. Willerson, E. C. Perin, and L. J. Wilson, "The use of gadolinium-carbon nanostructures to magnetically enhance stem cell retention for cellular cardiomyoplasty," Biomaterials 2014, 35, 720-726.