Mikos, Antonios G. - Rice University - Department of Chemistry

个人简介

Dipl.Ch.E. (1983) Aristotle University of Thessaloniki M.S.Ch.E. (1985) Purdue University Ph.D. (1988) Purdue University

研究领域

Our laboratory emphasizes the use of synthetic biodegradable polymers as supportive scaffolds for cells, as conduits for guided tissue growth, as specific substrates for targeted cell adhesion, or as stimulants for a desired cellular response. We are investigating bone regeneration and repair using a biodegradable polymer scaffold either by inducing bone tissue growth post-implantation or by seeding the scaffold with bone cells prior to implantation. We are developing new processing methods for manufacturing three-dimensional polymer scaffolds including combinations of solvent-casting or extrusion-molding with particulate-leaching techniques. We are further fabricating injectable, in situ polymerizable, biodegradable composite scaffolds for bone replacement also serving as carriers for bone cells and growth factors to induce a bone regeneration cascade. We are examining the effects of mechanical forces and flow on three-dimensional cultures of bone cells on the gene expression and the production of molecular mediators of mineralization and bone formation including extracellular matrix components and growth factors. We are also developing new CAD/CAM and polymer chemistry fabrication technologies for the production of synthetic biomimetic materials that exhibit the mechanical responsiveness and biochemical processing capabilities of living cells and tissues. We are synthesizing new injectable, in situ crosslinkable, biodegradable poly(ethylene glycol) copolyesters with covalently bound cell adhesion molecules for modulating cellular function to the hydrogel. We are designing new proactive hydrogels conducive to bone ingrowth but preclusive to fibrous infiltration for treating dental defects with guided tissue regeneration. Moreover, we are proposing the use of injectable biodegradable hydrogels after interventional cardiovascular procedures to repave and heal injured arteries and prevent arterial restenosis. We are fabricating thin films of biodegradable polymers with patterned surface chemistries and morphologies in an attempt to modulate the function of cultured cells with the ultimate goal of regenerating retinal pigment epithelium. We are manufacturing porous biodegradable polymer conduits for peripheral nerve regeneration to serve not only as guidance scaffolds but also as carriers for nerve growth factors and cells. Finally, we are developing non-viral gene delivery systems using synthetic polymers with targeting moieties for gene therapy.

近期论文

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K.M. Hubka, R.L. Dahlin, V.V. Meretoja, F.K. Kasper, and A.G. Mikos, "Enhancing Chondrogenic Phenotype for Cartilage Tissue Engineering: Monoculture and Coculture of Articular Chondrocytes and Mesenchymal Stem Cells," Tissue Eng. Part B: Reviews, 20, 641-654 (2014). S.-E. Lamhamedi-Cherradi, M. Santoro, V. Ramammoorthy, B.A. Menegaz, G. Bartholomeusz, L.R. Iles, H.M. Amin, A.J. Livingston, A.G. Mikos, and J.A. Ludwig, "3D Tissue-Engineered Model of Ewing’s Sarcoma," Adv. Drug Deliv. Rev., 79-80, 155-171 (2014). A.M. Tatara, M.E. Wong, and A.G. Mikos, "In Vivo Bioreactors for Mandibular Reconstruction," J. Dent. Res., 93, 1196-1202 (2014). R.L. Dahlin, V.V. Meretoja, M. Ni, F.K. Kasper, and A.G. Mikos, "Chondrogenic Phenotype of Articular Chondrocytes in Monoculture and Co-Culture with Mesenchymal Stem Cells in Flow Perfusion," Tissue Eng. Part A, 20, 2883-2891 (2014). S.R. Shah, A.M. Henslee, P.P. Spicer, S. Yokota, S. Petrichenko, S. Allahabadi, G.N. Bennett, M.E. Wong, F.K. Kasper, and A.G. Mikos, "Effects of Antibiotic Physicochemical Properties on their Release Kinetics from Biodegradable Polymer Microparticles," Pharm. Res., 31, 3379-3389 (2014). A.W.G. Nijhuis, S. Takemoto, M.R. Nejadnik, Y. Li, X. Yang, D.A. Ossipov, J. Hilborn, A.G. Mikos, M. Yoshinari, J.A. Jansen, and S.C.G. Leeuwenburgh, "Rapid Screening of Mineralization Capacity of Biomaterials by Means of Quantification of Enzymatically Deposited Calcium Phosphate," Tissue Eng. Part C: Methods, 20, 838-850 (2014). J.E. Trachtenberg, P.M. Mountziaris, J.S. Miller, M. Wettergreen, F.K. Kasper, and A.G. Mikos, "Open-Source Three-Dimensional Printing of Biodegradable Polymer Scaffolds for Tissue Engineering," J. Biomed. Mater. Res. Part A, 102A, 4326-4335 (2014). L.A. Kinard, R.L. Dahlin, J. Lam, S. Lu, E.J. Lee, F.K. Kasper, and A.G. Mikos, "Synthetic Biodegradable Hydrogel Delivery of Demineralized Bone Matrix for Bone Augmentation in a Rat Model," Acta Biomaterialia, 10, 4574-4582 (2014). C.J. Needham, S.R. Shah, R.L. Dahlin, L.A. Kinard, J. Lam, B.M. Watson, S. Lu, F.K. Kasper, and A.G. Mikos, "Osteochondral Tissue Regeneration Through Polymeric Delivery of DNA Encoding for the SOX Trio and RUNX2," Acta Biomaterialia, 10, 4103-4112 (2014). S. Lu, J. Lam, J.E. Trachtenberg, E.J. Lee, H. Seyednejad, J.J.J.P. van den Beucken, Y. Tabata, M.E. Wong, J.A. Jansen, A.G. Mikos, and F.K. Kasper, "Dual Growth Factor Delivery from Bilayered, Biodegradable Hydrogel Composites for Spatially-Guided Osteochondral Tissue Repair," Biomaterials, 35, 8829-8839 (2014). J. Lam, S. Lu, E.J. Lee, J.E. Trachtenberg, V.V. Meretoja, R.L. Dahlin, J.J.J.P. van den Beucken, Y. Tabata, M.E. Wong, J.A. Jansen, A.G. Mikos, and F.K. Kasper, "Osteochondral Defect Repair Using Bilayered Hydrogels Encapsulating Both Chondrogenically and Osteogenically Pre-Differentiated Mesenchymal Stem Cells in a Rabbit Model," Osteoarthritis Cartilage, 22, 1291-1300 (2014). J. Lam, K. Kim, S. Lu, Y. Tabata, D.W. Scott, A.G. Mikos, and F.K. Kasper, "A Factorial Analysis of the Combined Effects of Hydrogel Fabrication Parameters on the In Vitro Swelling and Degradation of Oligo(Poly(Ethylene Glycol) Fumarate) Hydrogels," J. Biomed. Mater. Res. Part A, 102A, 3477-3487 (2014). M. Santoro, A.M. Tatara, and A.G. Mikos, "Gelatin Carriers for Drug and Cell Delivery in Tissue Engineering," J. Controlled Release, 190, 210-218 (2014). E.L.S. Fong, M. Martinez, J. Yang, A.G. Mikos, N.M. Navone, D.A. Harrington, and M.C. Farach-Carson, "Hydrogel-Based 3D Model of Patient-Derived Prostate Xenograft Tumors Suitable for Drug Screening," Mol. Pharm., 11, 2040-2050 (2014). R.L. Dahlin, J.G. Gershovich, F.K. Kasper, and A.G. Mikos, "Flow Perfusion Co-Culture of Human Mesenchymal Stem Cells and Endothelial Cells on Biodegradable Polymer Scaffolds," Ann. Biomed. Eng., 42, 1381-1390 (2014). R.L. Dahlin, L.A. Kinard, J. Lam, C.J. Needham, S. Lu, F.K. Kasper, and A.G. Mikos, "Articular Chondrocytes and Mesenchymal Stem Cells Seeded on Biodegradable Scaffolds for the Repair of Cartilage in a Rat Osteochondral Defect Model," Biomaterials, 35, 7460-7469 (2014). B.M. Watson, F.K. Kasper, P.S. Engel, and A.G. Mikos, "Synthesis and Characterization of Injectable, Biodegradable, Phosphate-Containing, Chemically Cross-Linkable, Thermoresponsive Macromers for Bone Tissue Engineering," Biomacromolecules, 15, 1788-1796 (2014).