梁高林 - 东南大学 - 生物电子学国家重点实验室

个人简介

Dr. Gaolin Liang received his B.S. from Nanjing University in 1993. He got his Ph.D. from Fudan University in 2005. From Sept. 2005 to Jan. 2008, he conducted his postdoctoral fellow in the Chemistry Department of The Hong Kong University of Science and Technology under the supervision of Prof. Bing Xu. From Jan. 2008 to May 2010, he was postdoctoral fellow of School of Medicine Stanford University under the supervision of Prof. Jianghong Rao. He joined USTC as a full professor in the March of 2010. Then he joined SEU as a full professor in the August of 2018.

研究领域

1, Nanochemistry. We actively explore new methodologies (reactions) for synthesizing nanomaterials, including dendrimers, supramolecular hydrogelators, and inorganic nanoparticles for bioengineering applications. Currently, we are using CBT chemistry to synthesize dendrimers for biological applications. 2, Molecular and Cellular Imaging. We develop novel molecular probes for imaging or manipulating targeted biomolecules in normal and diseased states, usually for cancer early detection. Currently, we are developing MRI probes for cellular imaging and small animal imaging (mouse). The "smart" probes can self-assemble to form nanoparticles inside cells after being uptaken. Thus, the T1-weighted signals will be greatly enhanced at the targetting site (always tumors). 3, Imaging modality. We combine different imaging modalities for disease dignosis, therapy evaluation, et al. We are developing "smart" probes for OPT/CT, SPECT/CT, PET/CT, MR/CT imaging. Our endeavor aims to detect cancer development at an early stage. Thus, we have the opportunity of developing new anti-cancer drugs to inhibit the growth and metastasis of tumor.

近期论文

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Hai-Dong Xu,# Xiaotong Cheng,# Xianbao Sun, Peiyao Chen, Wenjun Zhan, Xiaoyang Liu, Xinliang Wang, Bing Hu, and Gaolin Liang*. Caspase-3-Triggered Intracellular Gadolinium Nanoparticle Formation for T1-Weighted Magnetic Resonance Imaging of Apoptosis In Vivo. Nano Lett. 2023. (DOI: 10.1021/acs.nanolett.3c01787). Qiaochu Jiang,# Wenjun Zhan,# Xiaoyang Liu, Lin Bai, Manli Wang, Ying Xu, and Gaolin Liang*. Assembly drives regioselective azide-alkyne cycloaddition reaction. Nat. Commun. 2023, 14, 3935. (DOI:10.1038/s41467-023-39658-0). Wenjun Zhan,# Lingling Xu,# Zhiyu Liu,# Xiaoyang Liu, Ge Gao, Tiantian Xia, Xiaotong Cheng, Xianbao Sun, Fu-Gen Wu, Qian Yu, and Gaolin Liang*. Tandem Guest-Host-Receptor Recognitions Precisely Guide Ciprofloxacin to Eliminate Intracellular Staphylococcus aureus. Angew. Chem., Int. Ed. 2023. (DOI:10.1002/anie.202306427). Yu Deng,# Xiang Shi,# Xinyi Hu,# Lingling Xu, Xiaoyang Liu, Ge Gao, Rui Wang*, and Gaolin Liang*. A Chemiluminescent Probe for Imaging Peroxynitrite in Inflammatory Cells and Tissues.Anal. Chem. 2023, 95(16), 6490-6500. (DOI:10.1021/acs.analchem.3c01124). Xiaoyang Liu, Wenjun Zhan, Ge Gao, Qiaochu Jiang, Xinping Zhang, Hongbo Zhang, Xianbao Sun, Wei Han, Fu-Gen Wu, and Gaolin Liang*. Apoptosis-Amplified Assembly of Porphyrin Nanofiber Enhances Photodynamic Therapy of Oral Tumor. J. Am. Chem. Soc. 2023.(DOI:10.1021/jacs.2c13189). Xianbao Sun, Tiantian Xia, Lingling Xu, Wenjun Zhan, and Gaolin Liang*. Facile Label-Free Three-Input Molecular Keypad Lock. Anal. Chem. 2023. (DOI: 10.1021/acs.analchem.3c00412). Xinyi Hu,# Runqun Tang,# Lin Bai, Songqin Liu, and Gaolin Liang* and Xiaobao Sun*. CBT-Cys click reaction for optical bioimaging in vivo. VIEW 2023, 20220065. (DOI: 10.1002/VIW.20220065). Wenjun Zhan, Ge Gao, Zhiyu Liu, Xiaoyang Liu, Lingling Xu, Manli Wang, Hai-Dong Xu, Runqun Tang, Jingyuan Cao, Xianbao Sun, and Gaolin Liang*. Self-Assembly of Adamantane-Peptide Conjugate for Combating Staphylococcus aureus Infection. Adv. Healthcare Mater. 2023, 202203283. (DOI: 10.1002/adhm.202203283). Haidong Xu, Rui Wang*, and Gaolin Liang*. Applications of Self-assembled Peptide Probes in Magnetic Resonance Imaging. Chem. J. Chinese Universities 2022, 43(12), 20220440. (DOI:10.7503/cjcu20220440). Lingling Xu,# Nanhui Liu,# Wenjun Zhan,# Yu Deng, Zhaoxia Chen, Xiaoyang Liu, Ge Gao, Qian Chen, Zhuang Liu, and Gaolin Liang*. Granzyme B Turns Nanoparticle Fluorescence “On” for Imaging Cytotoxic T Lymphocyte Activity in Vivo. ACS Nano 2022, 16(11), 19328–19334. (DOI:10.1021/acsnano.2c08896). Yaguang Wang, Di Wang, Chao Wu, Bin Wang, Shufang He, Hua Wang, Gaolin Liang*, and Ye Zhang*. MMP 9-instructed assembly of bFGF nanofibers in ischemic myocardium to promote heart repair. Theranostics 2022, 12(17), 7237–7249. (DOI:10.7150/thno.77345). Xiaotong Cheng, Tiantian Xia, Wenjun Zhan, Hai-Dong Xu, Jiaoming Jiang, Xiaoyang Liu, Xianbao Sun, Fu-Gen Wu, and Gaolin Liang*. Enzymatic Nanosphere-to-Nanofiber Transition and Autophagy Inducer Release Promote Tumor Chemotherapy. Adv. Healthcare Mater. 2022,11, 2201916. (DOI: 10.1002/adhm.202201916). Tiantian Xia, Xiaotong Cheng, Xianbao Sun*, and Gaolin Liang*. Photoswitchable Nanofiber–Nanoparticle Transformation in a Cosolvent Gel–Sol System. ACS Materials Lett. 2022, 4(10), 1962–1966. (DOI: 10.1021/acsmaterialslett.2c00670). Ge Gao, Xianbao Sun, Xiaoyang Liu, Runqun Tang, Manli Wang, Wenjun Zhan, Junnian Zheng*, and Gaolin Liang*. FAP-α-Instructed Coumarin Excimer Formation for High Contrast Fluorescence Imaging of Tumor. Nano Lett. 2022, 22(16), 6782–6786. (DOI: 10.1021/acs.nanolett.2c02540). Ge Gao, Yao-Wen Jiang, Wenjun Zhan, Xiaoyang Liu, Runqun Tang, Xianbao Sun, Yu Deng, Lingling Xu, and Gaolin Liang*. A Trident Molecule with Nanobrush-Nanoparticle-Nanofiber Transition Property Spatially Suppresses Tumor Metastasis. J. Am. Chem. Soc. 2022, 144(26), 11897–11910. (DOI: 10.1021/jacs.2c05743). Sicheng Liang, Zhuang Wang, Zhixin Zhou, Gaolin Liang*, Yuanjian Zhang*. Polymeric carbon nitride-based materials: Rising stars in bioimaging. Biosens. Bioelectron. 2022, 211, 114370. (DOI: 10.1016/j.bios.2022.114370). Xiang Shi, Ge Gao, Xiaoyang Liu, Lingling Xu, Yu Deng, Rui Wang*, Gaolin Liang*. Highly lipophilic coumarin fluorophore with excimer-monomer transition property for lipid droplet imaging. Chin. Chem. Lett. 2023, 34, 107613. (DOI: 10.1016/j.cclet.2022.06.036). Yue Hua, Han Yin, Xiaoyang Liu, Jinbing Xie, Wenjun Zhan*, Gaolin Liang* and Yang Shen. Salt-inducible Kinase 2-Triggered Release of Its Inhibitor from Hydrogel to Suppress Ovarian Cancer Metastasis. Adv. Sci. 2022, 2202260. (DOI: 10.1002/advs.202202260). Lingling Xu, Wenjun Zhan, Yu Deng, Xiaoyang Liu, Ge Gao, Xianbao Sun, and Gaolin Liang*. ROS Turn Nanoparticle Fluorescence on for Imaging Staphylococcus aureus Infection in Vivo. Adv. Healthcare Mater. 2022, 208, 2200453. (DOI: 10.1002/adhm.202200453). Xiang Shi, Yu Deng, Xiaoyang Liu, Ge Gao, Rui Wang, and Gaolin Liang*. An aminopeptidase N-activatable chemiluminescence probe for image-guided surgery and metastasis tracking of tumor. Biosens. Bioelectron. 2022, 208, 114-212. (DOI: 10.1016/j.bios.2022.114212). Bin Wang, # Chengfan Wu, # Shufang He, # Yaguang Wang, Di Wang, Hui Tao, Chenchen Wang, Xiaoxi Pang, Fei Li, Yue Yuan, Eric R. Gross, Gaolin Liang,* and Ye Zhang*. V1-Cal hydrogelation enhances its effects on ventricular remodeling reduction and cardiac function improvement post myocardial infarction. Chem. Eng. J. 2022, 433, 134450. (DOI: 10.1016/j.cej.2021.134450). Rui Luo, Chunqing Ou, Xinchao Li, Yanfang Wang, Wei Du, Gaolin Liang,* and Changyang Gong*. An Acidity-Initiated Self-Assembly/Disassembly Nanoprobe to Switch on Fluorescence for Tumor Targeted Near-Infrared Imaging. Nano Lett. 2022, 22, 151156. (DOI: 10.1021/acs.nanolett.1c03534). Chenchen Wang, Wei Du, Chengfan Wu, Shan Dan, Miao Sun, Tong Zhang, Bin Wang, Yue Yuan,* and Gaolin Liang*. Cathespin B-Initiated Cypate Nanoparticle Formation for Tumor Photoacoustic Imaging. Angew. Chem., Int. Ed. 2022, 61, e202114766. (DOI: 10.1002/anie.202114766). Huan Li,# Zijuan Hai,# Liwei Zou, Lele Zhang, Lulu Wang, Longsheng Wang,* and Gaolin Liang*. Simultaneous enhancement of T1 and T2 magnetic resonance imaging of liver tumor at respective low and high magnetic fields. Theranostics 2022, 12(1), 410-417. (DOI: 10.7150/thno.67155). Chengfan Wu, Chenchen Wang, Tong Zhang, Mengxing Wei, Yinglu Chen, Xiaoyan Li, Fuqiang Wang,* and Gaolin Liang*. Lysosome-Targeted and Fluorescence-Turned “On” Cytotoxicity Induced by Alkaline Phosphatase-Triggered Self-Assembly. Adv. Healthcare Mater. 2021, 11, 2101346. (DOI: 10.1002/adhm.202101346). Xiaodong Zhang, Xiaokai Chen,Yuxin Guo,Ge Gao, Dongdong Wang, Yinglong Wu, Jiawei Liu, Gaolin Liang, Yanli Zhao,* Fu-Gen Wu*. Dual Gate-Controlled Therapeutics for Overcoming Bacterium-Induced Drug Resistance and Potentiating Cancer Immunotherapy. Angew. Chem., Int. Ed. 2021, 60, 14013-14021. (DOI: 10.1002/anie.202102059). Tiantian Xia,Xiaotong Cheng, Wenjun Zhan,* Gaolin Liang*. Luciferase-Luciferin Bioluminescence System for Bioimaging Applications. Analysis & Sensing. 2021, 1, 138-147. (DOI: 10.1002/anse.202100035). Qiaochu Jiang, Xiaoyang Liu, Gaolin Liang,* and Xianbao Sun*. Self-assembly of peptide nanofibers for imaging applications. Nanoscale 2021, 13, 15142-15150.(DOI: 10.1039/D1NR04992E). Zhiyu Liu, Wenjun Zhan,* and Gaolin Liang*. In Situ Activatable Peptide-based Nanoprobes for Tumor Imaging. Chem. Res. Chinese Universities 2021, 37(4), 889-899. (DOI: 10.1007/s40242-021-1181-8). Yinglu Chen, Chengfan Wu, Chenchen Wang, Tong Zhang, Yue Hua, Yang Shen,* and Gaolin Liang*. Bioluminescence Imaging of Urokinase-Type Plasminogen Activator Activity in Vitro and in Tumors. Anal. Chem. 2021, 93(29), 9970-9973. (DOI: 10.1021/acs.analchem.1c02499). Ge Gao, Xianbao Sun, Xiaoyang Liu, Yao-Wen Jiang, Cheng, Runqun Tang, Yuxin Guo, Fu-Gen Wu* and Gaolin Liang*. Intracellular Nanoparticle Formation and Hydroxychloroquine Release for Autophagy-Inhibited Mild-Temperature Photothermal Therapy for Tumors. Adv. Funct. Mater. 2021, 2102832. (DOI: 10.1002/adfm.202100738). Xiaotong Cheng, Hai-Dong Xu, Huan-Huan Ran, Fu-Gen Wu,* and Gaolin liang*. Glutathione-Depleting Nanomedicines for Synergistic Cancer Therapy. ACS Nano 2021, 15(5), 8039–8068. (DOI:10.1021/acsnano.1c00498). Ge Gao, Xianbao Sun,* and Gaolin liang*. Nanoagent-Promoted Mild-T emperature Photothermal Therapy for Cancer Treatment. Adv. Funct. Mater., 2021, 2100738. (DOI: 10.1002/adfm.202100738). Peiyao Chen, Hongyong Wang, Hao Wu, Pei Zou, Chenchen Wang, Xiaoyang Liu, Yue Pan, Yaling Liu, and Gaolin liang*. Intracellular Synthesis of Hybrid Gallium-68 Nanoparticle Enhances MicroPET Tumor Imaging. Anal. Chem. 2021, 6329-6334. (DOI: 10.1021/acs.analchem.1c00747). Miaomiao Zhang, Chenchen Wang, Chen Yang, Haisi Wu, Huae Xu*, and Gaolin liang*. Using Fluorescence On/Off to Trace Tandem Nanofiber Assembly/Disassembly in Living Cells. Anal. Chem. 2021, 93, 14, 5665-5669. (DOI: 10.1021/acs.analchem.1c00220). Renuka Khatik, Zhengyun Wang, Fenfen Li, Debo Zhi,Sonia Kiran, Pankaj Dwivedi, Ronald X. Xu, Gaolin Liang*, Bensheng Qiu*, Qing Yang*. Magnus nano-bullets” as T1/T2 based dual-modal for in vitro and in vivo MRI visualization. Nanomedicine 2019, 15, 264-273 (DOI: 10.1016/j.nano.2018.10.005). Xiao Hu, Zijuan Hai, Chengfan Wu, Wenjun Zhan, and Gaolin Liang*. A Golgi-Targeting and Dual-Color “Turn-On” Probe for Spatially Precise Imaging of Furin. Anal. Chem. 2021, 93, 3, 1636-1642 (DOI: 10.1021/acs.analchem.0c04186). Zhonghua Shi*, Xiaoyan Li, Mengxing Wei, Peiyao Chen, Ting Zhang, Xiufeng Ling, Junqiang Zhang, Chun Zhao*, Fuqiang Wang*, and Gaolin Liang*. Receptor tyrosine kinases-instructed release of its inhibitor from hydrogel to delay ovarian aging. Biomaterials 2020, 120536. (DOI: 10.1016/j.biomaterials.2020.120536). Chenchen Wang, Wei Du, Tong Zhang, and Gaolin Liang*.A Bioluminescent Probe for Simultaneously Imaging Esterase and Histone Deacetylase Activity in a Tumor. Anal. Chem. 2020, 15275-15279. (DOI: 10.1021/acs.analchem.0c04227). Miaomiao Zhang, Yong Guan, Zheng Dang, Pinggen Zhang, Zhen Zheng, Liang Chen, Wen Kuang, Chenchen Wang, Gaolin Liang*.Directly observing intracellular nanoparticle formation with nanocomputed tomography. Sci. Adv. 2020, 6, eaba3190 (DOI: 10.1126/sciadv.aba3190). Jihua Chen, Yinchu Ma, Wei Du, Tianyue Dai, Yanfang Wang, Wei Jiang, Yifei Wan, Yucai Wang, Gaolin Liang* and Guangfeng Wang*. Furin-Instructed Intracellular Gold Nanoparticle Aggregation for Tumor Photothermal Therapy. Adv. Funct. Mater. 2020, 2001566 (DOI: 10.1002/adfm.202001566). Meihui Zhuang, Zhuanghao Hou, Peiyao Chen, Gaolin Liang* and Guangming Huang*. Introducing charge tag via click reaction in living cells for single cell mass spectrometry. Chem.Sci. 2020, 11, 7308 (DOI: 10.1039/d0sc00259c). Mengya Lv, Yanhao Zhang, Jiayi Fan, Yanyun Yang, Sheng Chen*, Gaolin Liang*, and Shusheng Zhang*. A near-infrared fluorescent probe for ratiometric sensing of SO2 in cells and zebrafish. Analyst 2020, Advance Article (DOI: 10.1039/d0an01468k). Yaguang Wang, Xiaohu Li, Peiyao Chen, Yu Dong, Gaolin Liang* and Yongqiang Yu*. Enzyme-instructed self-aggregation of Fe3O4 nanoparticles for enhanced MRI T2 imaging and photothermal therapy of tumors. Nanoscale 2020, 12, 1886 (DOI: 10.1039/c9nr09235h). Xiaoyang Liu, Xianbao Sun* and Gaolin liang*. Peptide-based supramolecular hydrogels for bioimaging applications. Biomater. Sci. 2020 (DOI: 10.1039/d0bm01020k). Yu Deng, Wenjun Zhan* and Gaolin liang*. Intracellular Self-Assembly of Peptide Conjugates for Tumor Imaging and Therapy. Adv. Healthcare Mater. 2020, 2001211 (DOI: 10.1002/adhm.202001211). Yanfang Wang, Wei Du, Tong Zhang, Yu Zhu, Yanhan Ni, Chenchen Wang, Fatima Maria Sierra Raya, Liwei Zou, Longsheng Wang,* and Gaolin Liang*. A Self-Evaluating Photothermal Therapeutictic Nanoparticle. ACS Nano 2020, 14, 9585-9593 (DOI: 10.1021/acsnano.9b10144). Ge Gao, Yaowen Jiang, Yuxin Guo, Haoran Jia, Xiaotong Cheng, Yu Deng, Xinwang Yu, Yaxuan Zhu, Haoyue Guo, Wei Sun, Xiaoyang Liu, Jing Zhao, Shihe Yang, Zhiwu Yu, Fatima Maria Sierra Raya, Gaolin Liang* and Fugen Wu*. Enzyme-Mediated T umor Starvation and Phototherapy Enhance Mild-T emperature Photothermal Therapy. Adv. Funct. Mater. 2020, 30, 1909391 (DOI: 10.1002/adfm.201909391) Xiaotong Cheng, Jiaoming Jiang and Gaolin Liang*. Covalently Conjugated Hydrogelators for Imaging and Therapeutic Applications.Bioconjugate Chem. 2020, 30, 1909391 (DOI: 10.1002/adfm.201909391) Yanhan Ni, Zijuan Hai, Tong Zhang, Yanfang Wang, Yanyun Yang, Shusheng Zhang*, and Gaolin Liang*. Cathepsin B Turning Bioluminescence “On” for Tumor Imaging. Anal. Chem. 2019, 91, 23, 14834-14837 (DOI: 10.1021/acs.analchem.9b04254). Hongyong Wang, Peiyao Chen, Hao Wu, Pei Zou, Jun Wu, Yaling Liu*, and Gaolin Liang*. Furin-Guided Intracellular 68Ga Nanoparticle Formation Enhancing Tumor MicroPET Imaging. Anal. Chem. 2019, 91, 23, 14842-14845 (DOI: 10.1021/acs.analchem.9b04788). Wei Du, Yuanyuan Chong, Xiaomu Hu, Yanfang Wang, Yu Zhu, Jihua Chen, Xiaoxia Li, Qun Zhang, Guangfeng Wang,* Jun Jiang,* and Gaolin Liang*. Increasing Photothermal Efficacy by Simultaneous Intra- and Intermolecular Fluorescence Quenching. Adv. Funct. Mater. 2020, 30, 1908073 (DOI: 10.1002/adfm.201908073). Peiyao Chen, Wen Kuang, Zhen Zheng, Shuye Yang, Yaling Liu, Lanhong Su, Kui Zhao,* and Gaolin Liang*.Carboxylesterase-Cleavable Biotinylated Nanoparticle for Tumor-Dual Targeted Imaging.Theranostics 2019, 9(24), 7359-7369 (DOI: 10.7150/thno.37625). Zhanling Ding, Hongbin Sun, Shuchao Ge, Yuan Cai, Yue Yuan, Zijuan Hai, Tongxiang Tao, Jinming Hu,* Bing Hu,* Junfeng Wang,* and Gaolin Liang*. Furin-Controlled Fe3O4 Nanoparticle Aggregation and 19F Signal “Turn-On” for Precise MR Imaging of Tumor. Adv. Funct. Mater. 2019,1903860 (DOI: 10.1002/adfm.201903860). Jiali Tan,* Mei Zhang, Zijuan Hai, Chengfan Wu, Jiong Lin, Wen Kuang, Hang Tang, Yulei Huang, Xiaodan Chen, and Gaolin Liang*. Sustained Release of Two Bioactive Factors from Supramolecular Hydrogel Promotes Periodontal Bone Regeneration. ACS Nano 2019, 13(5), 5616-5622(DOI: 10.1021/acsnano.9b00788). Zijuan Hai, Yanhan Ni, Dilizhatai Saimi, Hongyi Yang, Haiyang Tong, Kai Zhong,* and Gaolin Liang*. γ-Glutamyltranspeptidase-Triggered Intracellular Gadolinium Nanoparticle Formation Enhances the T2-Weighted MR Contrast of Tumor. Nano Lett. 2019, 19(4), 2428-2433, (DOI: 10.1021/acs.nanolett.8b05154). Peiyao Chen,# Yinchu Ma,# Zhen Zheng,# Chengfan Wu, Yucai Wang,* and Gaolin Liang*. Facile syntheses of conjugated polymers for photothermal tumour therapy. Nat. Commun. 2019, 2019, 10, 1192 (DOI: 10.1038/s41467-019-09226-6). Chengfan Wu, Rui Zhang, Wei Du, Liang Cheng,* and Gaolin Liang*. Alkaline Phosphatase-Triggered Self-Assembly of Near-Infrared Nanoparticles for the Enhanced Photoacoustic Imaging of Tumors. Nano Lett. 2018, 18(12), 7749-7754(DOI: 10.1021/acs.nanolett.8b03482). Wei Tang, Zhibin Zhao, Yuanyuan Chong, Chengfan Wu, Qingzhi Liu, Jingbo Yang, Rongbin Zhou, Zhe-Xiong Lian,* and Gaolin Liang*. Tandem Enzymatic Self-Assembly and Slow Release of Dexamethasone Enhances Its Antihepatic Fibrosis Effect. ACS Nano 2018, 12(10), 9966-9973(DOI: 10.1021/acsnano.8b04143). Jindao Wu,* Zhen Zheng, Yuanyuan Chong, Xiangcheng Li, Liyong Pu, Qiyun Tang, Liu Yang, Xuehao Wang,* Fuqiang Wang,*, and Gaolin Liang*. Immune Responsive Release of Tacrolimus to Overcome Organ Transplant Rejection. Adv. Mater. 2018, 30(45), 1805018 (DOI: 10.1002/adma.201805018).Video Abstract: https://v.qq.com/x/page/l0788apvupo.html. Yue Zhao, Zijuan Hai, Hongyong Wang, Lanhong Su, and Gaolin Liang*. Legumain-Specific Near-Infrared Fluorescence “Turn On” for Tumor-Targeted Imaging. Anal. Chem. 2018, 90(15), 8732-8735 (DOI: 10.1021/acs.analchem.8b02704). Hongbin He, Hua Jiang, Yun Chen, Jin Ye, Aoli Wang, Chao Wang, Qingsong Liu, Gaolin Liang, Xianming Deng*, Wei Jiang*, and Rongbin Zhou*. Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat. Commun. 2018, 9, 2550 (DOI: 10.1038/s41467-018-04947-6). Yi Huang, Hua Jiang, Yun Chen, Xiaqiong Wang, Yanqing Yang, Jinhui Tao, Xianming Deng, Gaolin Liang, Huafeng Zhang, Wei Jiang,* and Rongbin Zhou*. Tranilast directly targets NLRP3 to treat inflammasome-driven diseases. EMBO Mol. Med. 2018, 10: e8689 (DOI: 10.15252/emmm.201708689). Miaomiao Zhang and Gaolin Liang*. Applications of CBT-Cys click reaction: past, present, and future. Sci. China Chem. 2018, 61(9), 1088-1098 (DOI: 10.1007/s11426-018-9277-6). Zijuan Hai and Gaolin Liang*. Intracellular Self-Assembly of Nanoprobes for Molecular Imaging. Adv. Biosys. 2018, 2(8), 1800108 (DOI: 10.1002/adbi.201800108). Miaomiao Zhang, Lin Wang, Yangyang Zhao, Fuqiang Wang, Jindao Wu*, and Gaolin Liang*. Using Bioluminescence Turn-On to Detect Cysteine in Vitro and in Vivo. Anal. Chem. 2018, 90(8), 4951-4954 (DOI: 10.1021/acs.analchem.8b00682). Jindan Li, Zijuan Hai, Huiqiong Xiao, Xiaoyi Yi*, and Gaolin Liang*. Intracellular self-assembly of Ru(bpy)32+ nanoparticles enables persistent phosphorescence imaging of tumor. Chem. Commun. 2018, 54, 3460-3463 (DOI: 10.1039/C8CC01759J) Sonia Kiran, Zijuan Hai, Zhanling Ding, Lin Wang, Yaling Liu, Huafeng Zhang, and Gaolin Liang*. Alkaline phosphatase-triggered assembly of etoposide enhances its anticancer effect. Chem. Commun. 2018, 54, 1853-1856 (DOI: 10.1039/C7CC09365A). Zijuan Hai, Jingjing Wu, Dilizhatai Saimi, Yanhan Ni, Rongbin Zhou, and Gaolin Liang*. Smart Dual Quenching Strategy Enhances the Detection Sensitivity of Intracellular Furin. Anal. Chem. 2018, 90(3), 1520-1524 (DOI: 10.1021/ acs.analchem.7b05251). Wei Du, Xiaomu Hu, Weichen Wei, and Gaolin Liang*. Intracellular Peptide Self-Assembly: A Biomimetic Approach for in Situ Nano-drug Preparation. Bioconjugate Chem. 2018, 29(4), 826-837 (DOI: 10.1021/ acs.bioconjchem.7b00798). Wei Tang,# Zhibin Zhao,# Zhexiong Lian, and Gaolin Liang*. Fluorogenic Disassembly of Self-Quenched NIR Nanoparticles Enables Matrix Metalloproteinase Detection. J. Biomed. Nanotechnol. 2018, 14, 304-311 (DOI: 10.1166/ jbn.2017.2473).