个人简介

B.S. Chemistry, University of Science and Technology of China, 1994 Ph.D., Chemistry, Massachusetts Institute of Technology, 2000 Postdoctoral Fellow, Chemical Biology, Harvard University, 2000-2002

研究领域

Inorganic Chemistry/Chemical Biology

Our research program spans a broad range of chemical biology, nucleic acid chemistry and biology, epigenetics, cell biology, bioinorganic chemistry, structural biology, microbiology, and genomics. We probe the pathways and mechanisms of nucleic acids modification and demodification. We study virulence and antibiotic resistance regulation in human pathogens. We also study selective metal ion recognition and sensing by naturally occurring and engineered proteins, and live-cell imaging of metal ions and other small molecules such as H2S, heme, and CO.

近期论文

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Nacthergaele, S.; He, C. Chemical Modifications in the Life of an mRNA transcript. Ann. Rev. Genet 2018, In Press. [pdf] Shi, H.; Zhang, X.; Weng, Y. L.; Lu, Z.; Liu, Y.; Lu, Z.; Li, J.; Hao, P.; Zhang, Y.; Zhang, F.; Wu, Y.; Delgado, J. Y.; Su, Y.; Patel, M. J.; Cao, X.; Shen, B.; Huang, X.; Ming, G. L.; Zhuang, X.; Song, H.*; He, C.*; Zhou, T.* m6A facilitates hippocampus-dependent learning and memory through Ythdf1. Nature 2018, In Press. [pdf] Wei, J. B.; Liu, F. G.; Lu, Z. K.; Fei, Q. L.; Ai, Y. X.; He, P. D.; Shi, H. L.; Cui, X. L.; Su, R.; Klungland, A.; Jia, G. F.; Chen, J. J.; He, C. Differential m6A, m6Am, and m1A demethylation mediated by FTO in the cell nucleus and cytoplasm. Mol. Cell 2018, 71, 973-985.[pdf] Li, Z.; Qian, P.; Shao, W.; Shi, H.; He, X. C.; Gogol, M.; Yu, Z.; Wang, Y.; Qi, M.; Zhu, Y.; Perry, J. M.; Zhang, K.; Tao, F.; Zhou, K.; Hu, D.; Han, Y.; Zhao, C.; Alexander, R.; Xu, H.; Chen, S.; Peak, A.; Hall, K.; Peterson, M.; Perera, A.; Haug, J. S.; Parmely, T.; Li, H.; Shen, B.; Zeitlinger, J.; He, C.; Li, L. Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 2018, 28, 904-917.[pdf] Koranda, J. L.; Dore, L.; Shi, H.; Patel, M. J.; Vaasjo, L. O.; Rao, M. N.; Chen, K.; Lu, Z.; Yi, Y.; Chi, W.; He, C.*; Zhuang, X.*. Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning. Neuron 2018, 99, 283-292. [pdf] Lu, W.; Tirumuru, N.; St Gelais, C.; Koneru, P. C.; Liu, C.; Kvaratskhelia, M.; He, C.; Wu, L. N6-methyladenosine-binding proteins suppress HIV-1 infectivity and viral production. J. Biol. Chem. 2018, In Press. [pdf] Li, M.; Zhao, X.; Wang, W.; Shi, H.; Pan, Q.; Lu, Z.; Perez, S. P.; Suganthan, R.; He, C.; Bjørås, M.; Klungland, A. Ythdf2-mediated m6A mRNA clearance modulates neural development in mice. Genome Biol. 2018, 19, 69. [pdf] Zhao, Y. T.; Kwon, D. Y.; Johnson, B. S.; Fasolino, M.; Lamonica, J. M.; Kim, Y., J.; Zhao, B. S.; He, C.; Vahedi, G.; Kim, T. H.; Zhou, Z. Long genes linked to autism spectrum disorders harbor broad enhancer-like chromatin domains. Genome Res. 2018, 28, 933-942. [pdf] Zhu, S.; Beaulaurier, J.; Deikus, G.; Wu, T. P.; Strahl, M.; Hao, Z.; Luo, G.; Gregory, J. A.; Chess, A.; He, C.; Xiao, A.; Sebra, R.; Schadt, E. E.; Fang, G. Mapping and characterizing N6-methyladenine in eukaryotic genomes using single-molecule real-time sequencing. Genome Res. 2018, 28, 1067-1078. [pdf] Hesser, C. R.; Karijolich, J.; Dominissini, D.; He, C.; Glaunsinger, B. A. N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection. PLoS Pathog. 2018, 14, e1006995 [pdf] Cheng, J. X.; Chen, L.; Li, Y.; Cloe, A.; Yue, M.; Wei, J.; Watanabe, K. A.; Shammo, J. M.; Anastasi, J.; Shen, Q. J.; Larson, R. A.; He, C.; Le Beau, M. M.; Vardiman, J. W. RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia. Nat. Commun. 2018, 9, 1163. [pdf] Wen, J.; Lv, R.; Ma, H.; Shen, H.; He, C.; Wang, J.; Jiao, F.; Liu, H.; Yang, P.; Tan, L.; Lan, F.; Shi, Y. G.*; He, C.*; Shi, Y.*; Diao, J.*. Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal. Mol. Cell 2018, 69, 1028-1038. [pdf] Huang, H.; Weng, H.; Sun, W.; Qin, X.; Shi, H.; Wu, H.; Zhao, B. S.; Mesquita, A.; Liu, C.; Yuan, C. L.; Hu, Y. C.; Hüttelmaier, S.; Skibbe, J. R.; Su, R.; Deng, X.; Dong, L.; Sun, M.; Li, C.; Nachtergaele, S.; Wang, Y.; Hu, C.; Ferchen, K.; Greis, K. D.; Jiang, X.; Wei, M.; Qu, L.; Guan, J. L.; He, C.*; Yang, J.*; Chen, J.*. Recognition of RNA N6-methyladenosine by IGBP2 proteins enhances mRNA stability and translation. Nat. Cell Biol. 2018, 20, 285-295. [pdf] Ji, L.; Jordan, W. T.; Shi, X.; Hu, L.; He, C. Schmitz, R. J. TET-mediated epimutagenesis of the Arabidopsis thaliana methylome. Nat. Commun. 2018, 9, 895. [pdf] Choi, J.; Indrisiunaite, G.; DeMirci, H.; Ieong, K. W.; Wang, J.; Petrov, A.; Prabhakar, A.; Rechavi, G.; Dominissini, D.; He, C.; Ehrenberg, M.; Puglisi, J. D. 2'-O-Methylation in mRNA disrupts tRNA decoding during translation elongation. Nat. Struct. Mol. Biol. 2018, 25, 208-216. [pdf] Zhao, B. S.; Nachtergaele, S.; Roundtree, I. A.; He, C. Our views of dynamic N6-methyladenosine RNA methylation. RNA 2018, 24, 268-272. [pdf] Yue, Y.; Liu, J.; Cui, X.; Cao, J.; Luo, G.; Zhang, Z.; Gao, M.; Shu, X.; Ma, H.; Wang, F.; Shen, B.; Wang, Y.; Feng, X.; He, C.*; Liu, J.*. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018, 4, 10. [pdf] Tian, X.; Sun, B.; Chen, C.; Gao, C.; Zhang, J.; Lu, X.; Wang, L.; Li, X.; Xing, Y.; Liu, R.; Han, X.; Qi, Z.; Zhang, X.; He, C.; Han, D.; Yang, Y. G.; Kan, Q. Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer. Cell Res. 2018, 25, 597-600. [pdf] Shi, H.; He, C. Phasing Gene Expression: mRNA N6-Methyladenosine Regulates Temporal Progression of Mammalian Cortical Neurogenesis. Biochemistry 2018, 57, 1055-56. [pdf] Weng, Y. L.; Wang, X.; An, R.; Cassin, J.; Vissers, C.; Liu, Y.; Liu, Y.; Xu, T.; Wang, X.; Wong, S. Z. H.; Joseph, J.; Dore, L. C.; Dong, Q.; Zheng, W.; Jin, P.; Wu, H.; Shen, B.; Zhuang, X.; He, C.; Liu, K.; Song, H.; Ming, G. L. Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System. Neuron 2018, 97, 313-325. [pdf]