蒋序林 - 武汉大学 - 化学与分子科学学院

研究领域

高分子化学与物理、生物医用高分子、高分子分离与表征 1. 可控高分子的合成、改性及共轭技术的研究 2. 基因药物用新型可降解高分子载体的研究 3. 热敏性可降解高分子药物靶向载体的研究（抗肿瘤药物、多肽蛋白质药物） 4. HPLC分离与表征功能高分子

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J. Liu, Y.-L. Xu, Q.-Z. Yang, C. Li, W. E. Hennink, R.-X. Zhuo,X.-L. Jiang*, Reduction Biodegradable Brushed PDMAEMA Derivatives Synthesized by ATRP and Click Chemistry for Gene Delivery, Acta Biomater, 2013, 9, 7758-7766. Y.-Y. Ma, X.-L. Jiang*, R.-X. Zhuo, Biodegradable and Thermosensitive Micelles of Amphiphilic Polyaspartamide Derivatives Containing Aromatic Groups for Drug Delivery, J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 3917-3924. X.-G. Huang, X.-L. Jiang*, Q.-Z. Yang, Y.-F. Chu, G.-Y. Zhang, B. Yang, R.-X. Zhuo, Triple-Stimuli (pH/Thermo/Reduction) Sensitive Copolymers for Intracellular Drug Delivery, J. Mater. Chem. B, 2013,1, 1860-1868. G.-Y. Zhang, J. Liu, Q.-Z. Yang, R.-X. Zhuo, X.-L. Jiang*, Disulfide-Containing Brushed Polyethylenimine Derivative Synthesized by Click Chemistry for Nonviral Gene Delivery, Bioconjugate Chem. 2012, 23, 1290-1299. X.-L. Jiang*, L.-H. Li, J. Liu, W. E. Hennink, R.-X. Zhuo，Facile Fabrication of Thermo-Responsive and Reduction-Sensitive Polymeric Micelles for Anticancer Drug Delivery, Macromol. Biosci. 2012, 12, 703-711. X.-G. Huang, X.-L. Jiang*, R.-X. Zhuo, Microwave-assisted solid-phase synthesis of pH-responsive polyaspartamide derivatives, Carbohydrate Polymers, 2012, 89,788-794 X.-L. Jiang*, J. Liu, L. Xu, R.-X. Zhuo，Disulfide-Containing Hyperbranched Polyethylenimine Derivative via Click Chemistry for Nonviral Gene Delivery，Macromol. Chem.Phys., 2011, 212, 64-71. X.-L. Jiang*, Y.-F. Chu, J. Liu, G.-Y. Zhang and R.-X. Zhuo，Aqueous SEC Analysis of Cationic Polymers ass Gene Carriers，Chinese Journal of Polymer Science 2011, 29(4), 421-426 蒋序林, 刘佳, 张光彦, 杨奇志, 卓仁禧, 可还原降解的梳型高分子基因载体及其制备方法, 中国发明专利, ZL201110020684.8 X.-L. Jiang*, L.-H. Li, J. Liu, R.-X. Zhuo, Reduction-responsive polymeric micelles for anticancer drug delivery, J. Control. Release, 2011, 152 S1, e36-e37. J. Liu, L. Xu,X.-L. Jiang*, W. E. Hennink, X.-M. Wang, R.-X. Zhuo, Disulfide-containing cross-linked PEI derivative synthesized by click chemistry for non-viral gene delivery, J. Control. Release, 2011, 152, S1, e157-e159 Y. Chen, L.-Z. Zhou, Y. Pang, W. Huang, F. Qiu, X.-L. Jiang, X.-Y. Zhu,D.-Y. Yan, and Q. Chen, Photoluminescent Hyperbranched Poly(amido amine) Containing β-Cyclodextrin as a Nonviral Gene Delivery, Bioconjugate Chem. 2011, 22, 1162-1170. J. Liu, X.-L. Jiang*, L. Xu, X.-M. Wang, W. E. Hennink, R.-X. Zhuo，Novel Reductive Crosslinked Polyethylenimine Derivative by Click Chemistry for Nonviral Gene Delivery, Bioconjugate Chem. 2010, 21(10), 1827-1835. 蒋序林, 刘佳, 徐丽, 卓仁禧, 还原敏感性聚乙烯亚胺衍生物及其制备方法和应用，中国发明专利， ZL201010154628.9 L.-H. Li,X.-L. Jiang*, R.-X. Zhuo, Synthesis and Characterization of Thermoresponsive Polymers Containing Reduction-Sensitive Disulfide Linkage, J Polym Sci Part A: Polym Chem 2009, 47: 5989-5997. 蒋序林, 李丽花, 卓仁禧, 还原敏感性的两亲性嵌段共聚物及其胶束 , 中国发明专利, ZL200910273157.0 X.-L. Jiang, M. C. Lok, C. F. van Nostrum, W. E. Hennink, Degradable-Brushed pHEMA-pDMAEMA Synthesized via ATRP and Click Chemistry for Gene Delivery, Bioconjugate Chem., 2007, 18(6), 2077-2084. D. F. Vlugt-Wensink, X.-L. Jiang, G. Schotman, G. Kruijtzer, A. Vredenberg, J.T. Chung, Z. Zhang, C. Versluis, D. Ramos, R. Verrijk, W. Jiskoot, D. J. A. Crommelin, W. E. Hennink, “In Vitro Degradation Behavior of Microspheres Based on Cross-Linked Dextran”, Biomacromolecules,2006,7(11), 2983-2990. X.-L. Jiang, A. van der Horst, M.J. van Steenbergen, N. Akeroyd, C.F. van Nostrum, P.J. Schoenmakers and W.E. Hennink, “Aqueous size-exclusion chromatography of cationic polymers for gene delivery”,J. Controlled Release, 2006, 116(2), e69-e71. C. Hiemstra, Z.Y. Zhong, X.-L. Jiang, W.E. Hennink, P.J. Dijkstra and J. Feijen, “PEG–PLLA and PEG–PDLA multiblock copolymers: Synthesis and in situ hydrogel formation by stereocomplexation”,J. Controlled Release, 2006, 116(2), e17-e19. C. Lin, Z.-Y. Zhong, M. C. Lok, X.-L. Jiang, W. E. Hennink, J. F. and Johan F.J. Engbersen，“Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: Synthesis and in vitro gene transfer properties”,J. Controlled Release, 2006, 116(2), 130-137.