田沺 - 武汉大学 - 化学与分子科学学院

个人简介

教育背景： 2000.09 - 2004.06，武汉大学化学与分子科学学院，大学本科，导师：万婕教授 2004.09 - 2009.06，武汉大学化学与分子科学学院，博士研究生，导师：周翔教授 2010.05 - 2012.05，武汉大学生命科学学院，博士后，合作导师：吴建国教授工作经历： 2012.11 - 2015.10，武汉大学化学与分子科学学院，副教授 2015.11 - 至今，武汉大学化学与分子科学学院，教授获奖荣誉：国家优青获得者、武汉大学珞珈青年学者

研究领域

围绕核酸化学生物学开展工作，主要针对特殊二级结构核酸（G - 四链核酸、左手螺旋核酸 Z-DNA）以及修饰核酸，进行结构与功能研究；发展小分子探针策略，对核酸的结构和功能进行调控；拓展以特殊二级结构核酸为靶标的创新药物设计和调控工具系统；解决传统方向以外的新功能揭示以及创新应用拓展

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Shaoru Wang#, Lingyu Wu#, Haiyan Huang#, Wei Xiong, Jian Liu, Lai Wei, Ping Yin, Tian Tian*, Xiang Zhou*. Conditional control of RNA-guided nucleic acid cleavage and gene editing. Nature Communications, 2020, 11, 91. 2. Shaoru Wang#, Haiyan Huang#, Jian Liu, Lai Wei, Lingyu Wu, Wei Xiong, Ping Yin, Tian Tian*, Xiang Zhou*. The manipulation of RNA-guided nucleic acid cleavage with ninhydrin chemistry. Advanced Science, 2020, 11, 1903770. 3.Wang, S. R.#; Min, Y. Q.#; Wang, J. Q.; Liu, C. X.; Fu, B. S.; Wu, F.; Wu, L. Y.; Qiao, Z. X.; Song, Y. Y.; Xu, G. H.; Wu, Z. G.; Huang, G.; Peng, N. F.; Huang, R.; Mao, W. X.; Peng, S.; Chen, Y. Q.; Zhu, Y.;Tian, T.*; Zhang, X. L. *; Zhou, X. *, A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti-hepatitis C target.Science Advances2016,2(4), e1501535. (Science子刊) 4.Tian, T.#; Chen, Y.#; Wang, S.*; Zhou, X.*, G-Quadruplex: A Regulator of Gene Expression and Its Chemical Targeting.Chem 2018,4, 1314-1344. (Cell子刊) 5. Wang, S. R.#; Zhang, Q. Y.#; Wang, J. Q.#; Ge, X. Y.; Song, Y. Y.; Wang, Y. F.; Li, X. D.; Fu, B. S.; Xu, G. H.; Shu, B.; Gong, P.; Zhang, B. *;Tian, T.*; Zhou, X. *, Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene.Cell Chemical Biology2016,23(9), 1113-22. (Cell子刊) 6. Wang, S.#; Song, Y.#; Wei, L.; Liu, C.; Fu, B.; Wang, J.; Yang, X.; Liu, Y.; Liu, S.;Tian, T.*; Zhou, X.*, Cucurbit[7]uril-Driven Host-Guest Chemistry for Reversible Intervention of 5-Formylcytosine-Targeted Biochemical Reactions.Journal of the American Chemical Society2017,139(46), 16903-12. 7.Tian, T.#; Song, Y.#; Wang, J.; Fu, B.; He, Z.; Xu, X.; Li, A.; Zhou, X.; Wang, S. *; Zhou, X. *, Small-Molecule-Triggered and Light-Controlled Reversible Regulation of Enzymatic Activity.Journal of the American Chemical Society2016,138(3), 955-61. 8. Wang, S.; Long, Y.; Wang, J.; Ge, Y.; Guo, P.; Liu, Y.;Tian, T.*; Zhou, X. *, Systematic investigations of different cytosine modifications on CpG dinucleotide sequences: the effects on the B-Z transition.Journal of the American Chemical Society2014,136(1), 56-9. 9.Tian, T.#; Song, Y.#; Wei, L.#; Wang, J.; Fu, B.; He, Z.; Yang, X. R.; Wu, F.; Xu, G.; Liu, S. M.; Li, C.; Wang, S. *; Zhou, X. *, Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host-guest interactions.Nucleic Acids Research2017,45(5), 2283-2293. 10. Wang, S.#; Song, Y.#; Wang, Y.; Li, X.; Fu, B.; Liu, Y.; Wang, J.; Wei, L.;Tian, T.*; Zhou, X. *, The m6A methylation perturbs the Hoogsteen pairing-guided incorporation of an oxidized nucleotide.Chemical Science2017,8(9), 6380-6388.