Nowick, James S. - University of California, Irvine

个人简介

•American Association for the Advancement of Science (AAAS) Fellow •NOGLSTP Scientist of the Year Award •UCI School of Physical Sciences Award for Outstanding Contributions to Undergraduate Education •American Chemical Society Arthur C. Cope Scholar Award •UCI Chancellor's Award for Excellence in Undergraduate Research •Alfred P. Sloan Research Fellowship •Camille Dreyfus Teacher-Scholar Award •Presidential Faculty Fellow •UCI Award for Outstanding Faculty Contribution to Undergraduate Research •Arnold and Mabel Beckman Foundation Young Investigator •National Science Foundation Young Investigator •American Cancer Society Junior Faculty Research Award •Camille and Henry Dreyfus Foundation Distinguished New Faculty Award •National Science Foundation Postdoctoral Fellow •American Chemical Society Division of Organic Chemistry Graduate Fellow •National Science Foundation Graduate Fellow

研究领域

Chemical Biology/Organic and Synthetic/Polymer/Materials/Nanoscience

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

"A Fibril-like Assembly of Oligomers of a Peptide Derived from β-Amyloid" Pham, J. D.; Spencer, R.; Chen, K. H.; Nowick, J. S. J. Am. Chem. Soc. 2014, 136, 12682-12690. "X-ray Crystallographic Structures of Trimers and Higher-Order Oligomeric Assemblies of a Peptide Derived from Aß17–36" Spencer, R.; Li, H.; Nowick, J. S. J. Am. Chem. Soc. 2014, 136, 5595-5598. "Polymorphism of Oligomers of a Peptide from β-Amyloid" Pham, J. D.; Demeler, B.; Nowick, J. S. J. Am. Chem. Soc. 2014, 136, 5432-5442. Spotlight in JACS "Finding the Solution: The Structure of Soluble Amyloid Oligomers" "Mechanism of IAPP Amyloid Fibril Formation Involves an Intermediate with a Transient β-Sheet" Buchanan, L. E.; Dunkelberger, E. B.; Tran, H. Q.; Cheng, P.-N.; Chiu, C.-C.; Cao, P.; Raleigh, D. P.; de Pablo, J. J.; Nowick, J. S.; Zanni, M. T. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 19285-19290. "Structures of Oligomers of a Peptide from β-Amyloid" Pham, J. D.; Chim, N.; Goulding, C. W.; Nowick, J. S. J. Am. Chem. Soc. 2013, 135, 12460-12467. "Recipe for ß-Sheets: Foldamers Containing Amyloidogenic Peptide Sequences" Spencer, R.; Chen, K. H.; Manuel, G.; Nowick, J. S. Eur. J. Org. Chem. 2013, 3523-3528. "A Hydrophobic Surface is Essential to Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide" Zheng, J.; Baghkhanian, A. M.; Nowick, J. S. J. Am. Chem. Soc. 2013, 135, 6846-6852. "The Supramolecular Chemistry of β-Sheets" Cheng, P.-N.; Pham, J. D.; Nowick, J. S. J. Am. Chem. Soc. 2013, 135, 5477–5492. "Amyloid β-Sheet Mimics that Antagonize Protein Aggregation and Reduce Amyloid Toxicity" Cheng, P.-N.; Liu, C.; Zhao, M.; Eisenberg, D.; Nowick, J. S. Nature Chemistry 2012, 4, 927-933. "Out-of-Register β-Sheets Suggest a Pathway to Toxic Amyloid Aggregates" Liu, C.; Zhao, M.; Jiang, L.; Cheng, P.-N.; Park, J.; Sawaya,. M. R.; Pensalfini, A.; Gou, D.; Berk, A. J.; Glabe, C. G.; Nowick, J. S.; Eisenberg, D. Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 20913-20918. "Heterodivalent Linked Macrocyclic β-Sheets with Enhanced Activity against Aβ Aggregation: Two Sites are Better than One." Cheng, P.-N.; Spencer, R.; Woods, R. J.; Glabe, C. G.; Nowick, J. S. J. Am. Chem. Soc. 2012, 133, 14179-14184. "Giant Macrolactams Based on β-Sheet Peptides" Cheng, P.-N.; Nowick, J. S. J. Org. Chem. 2011, 76, 3166-3173. "Characteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic β-Sheet Mimics" Liu, C.; Sawaya, M. R.; Cheng, P.-N.; Zheng, J.; Nowick, J. S.; Eisenberg, D. J. Am. Chem. Soc. 2011, 133, 6736-6744. "Macrocyclic β-Sheet Peptides that Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide" Zheng, J.; Liu, C.; Sawaya, M. R.; Vadla, B.; Khan, S.; Woods, R. J.; Eisenberg, D.; Goux, W. J.; Nowick, J. S. J. Am. Chem. Soc. 2011, 133, 3144-3157. "X-ray Crystallographic Structure of an Artificial β-Sheet Dimer" Khakshoor, O.; Lin, A. J.; Korman, T. P.; Sawaya, M. R.; Tsai, S.-C.; Eisenberg, D.; Nowick, J. S. J. Am. Chem. Soc. 2010, 132, 11622-11628. "Nanometer-Scale Water-Soluble Macrocycles from Nanometer-Sized Amino Acids" Gothard, C. M.; Nowick, J. S. J. Org. Chem. 2010, 75 1822-1830. "Use of Disulfide "Staples" To Stabilize β-Sheet Quaternary Structure" Khakshoor, O.; Nowick, J. S. Org. Lett. 2009, 11, 3000-3003. "A New Artificial β-Sheet that Dimerizes through Parallel β-Sheet Interactions" Levin, S.; Nowick, J. S. Org. Lett. 2009, 11, 1003-1006. "Exploring β-Sheet Structure and Interactions with Chemical Model Systems" Nowick, J. S. Acc. Chem. Res. 2008, 41, 1319-1330. "Functionalized Analogues of an Unnatural Amino Acid that Mimics a Tripeptide β-Strand" Khasanova, T. V.; Khakshoor, O.; Nowick, J. S. Org. Lett. 2008, 10, 5293-5296. "An Artificial β-Sheet That Dimerizes through Parallel β-Sheet Interactions" Levin, S.; Nowick, J. S. J. Am. Chem. Soc. 2007, 129, 13043-13048. "Nanometer-Sized Amino Acids for the Synthesis of Nanometer-Scale Water-Soluble Molecular Rods of Precise Length" Gothard, C. M.; Rao, N. A.; Nowick, J. S. J. Am. Chem. Soc. 2007, 129, 7272-7273. "Macrocyclic β-Sheet Peptides that Mimic Protein Quaternary Structure through Intermolecular β-Sheet Interactions" Khakshoor, O.; Demeler, B.; Nowick, J. S. J. Am. Chem. Soc. 2007, 129, 5558-5569. "Cyclic Modular β-Sheets" Woods, R. J.; Brower, J. O.; Castellanos, E.; Hashemzadeh, M.; Khakshoor, O.; Russu, W. A.; Nowick, J. S. J. Am. Chem. Soc. 2007, 129, 2548-2558. "A New Class of Macrocyclic Receptors from iota-Peptides" Kang, S.-W. Gothard, C. M.; Maitra, S.; Atia-tul-Wahab; Nowick, J. S. J. Am. Chem. Soc. 2007, 129, 1486-1487. "What I Have Learned by Using Chemical Model Systems to Study Biomolecular Structure and Interactions" Nowick, J. S. Org. Biomol. Chem. 2006, 4, 3869-3885. "The Absence of Favorable Aromatic Interactions between β-Sheet Peptides" Chung, D. M.; Dou, Y.; Baldi, P.; Nowick, J. S. J. Am. Chem. Soc. 2005, 127, 9998-9999. "Enantioselective Molecular Recognition between β-Sheets" Chung, D. M.; Nowick, J. S. J. Am. Chem. Soc. 2004, 126, 3062-3063. "DSA: A New Internal Standard for NMR Studies in Aqueous Solution", Nowick, J. S.; Khakshoor, O.; Hashemzadeh, M.; Brower, J. O. Org. Lett. 2003, 5, 3511-3513. "Sequence-Selective Molecular Recognition Between β-Sheets", Nowick, J. S.; Chung, D. M. Angew. Chem., Int. Ed. Engl. 2003, 42, 1765-1768. "A Ribozyme with Michaelase Activity: Synthesis of the Substrate Precursors" Eisenführ, A.; Arora, P. S.; Sengle, G.; Takaoka, L. R.; Nowick J. S.; Famulok, M. Bioorg. Med. Chem. 2003, 11, 235-249. "A New Turn Structure for the Formation of β-Hairpins in Peptides", Nowick, J. S.; Brower, J. O. J. Am. Chem. Soc. 2003, 125, 876-877. "Methylglyoxal Synthetase, enol-Pyruvaldehde, Glutathione, and the Glyoxalase System" Rose, I. A.; Nowick, J. S. J. Am. Chem. Soc. 2002, 124, 13047-13052.