Chmielewski, Jean A. - Purdue University

个人简介

•ALICE WATSON KRAMER DISTINGUISHED PROFESSOR OF CHEMISTRY - Purdue University, 2006 •PROFESSOR OF BIOMEDICAL ENGINEERING - Purdue University, 2009 •PROFESSOR OF CHEMISTRY - Purdue University, 2000 •ASSOCIATE PROFESSOR OF CHEMISTRY - Purdue University, 1996 •ASSISTANT PROFESSOR OF CHEMISTRY - Purdue University, 1990 •NIH POSTDOCTORAL FELLOW - University of California, Berkeley, 1988-1990 (with Prof. Peter Schultz) •NIH POSTDOCTORAL FELLOW - Rockefeller University, 1988 (with Dr. E. T. Kaiser) •PhD - Columbia University, 1988 (with Prof. Ronald Breslow) •BS - Saint Joseph's University, 1983 (with Dr. George Nelson)

近期论文

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Lee, S.-G.; Lee, J.; Chmielewski, J. “Investigation of pH-Dependent Collagen Triple Helix Formation” Angewandte Chemie 2008, 47, 8429-8432. Pires, M.; Chmielewski, J. “Fluoresence Imaging of Cellular Glutathione Using a Latent Fluorophore” Org. Lett. 2008, 10, 837-840. Gaddis, B.; Rubert, C.; Chmielewski, J. “Inhibitors of Anthrax Lethal Factor Based on N-oleoyldopamine” Bioorg. Med. Chem. Lett. 2008, 18, 2467-2470. Zhu, H.; Coleman, D.; Dehen, C.; Geisler, I.; Chmielewski, J.; Simpson, G.; Wei, A. “Assembly of Dithiocarbamate-Anchored Monolayers on Gold Surfaces in Aqueous Solutions” Langmuir 2008, 24, 8660-8666. Pires, M. M.; Chmielewski, J. “Self Assembly of Collagen Peptides into Microflorettes via Metal Coordination” J. Am. Chem. Soc. 2009, 131, 2706-2712. Pires, M.; Hrycyna, C.; Chmielewski, J. “Inhibition of P-Glycoprotein-Mediated Taxol Resistance by Reversibly-Linked Quinine Homodimers” Molecular Pharmacology, 2009, 75, 92-100. Geisler, I, Chmielewski, J. “Cationic Amphiphilic Polyproline Helices (CAPHs): Side Chain Variations and Cell Specific Internalization” Chem. Biol. Drug Des. 2009, 73, 39-45. Bowman, M.; Chmielewski, J. “Sidechain Crosslinked Inhibitors of HIV Protease Dimerization and Activity” Bioorg. Med. Chem. 2009, 17, 967-976. Davis, D. A., Reynolds, I., Daniels, S., Stahl, S., Kaufman, J., Wingfield, P., Bowman, M., Chmielewski, J., Yarchoan, R. “Characterizing Dimerization Inhibition of a Multi-Drug Resistant HIV-1 Protease Using a Novel Size Exclusion Chromatographic Assay” Biochem. J. 2009, 419, 497-506. Pires, M. M.; Przybyla, D.; Chmielewski, J. “A Metal-Collagen Peptide Framework for 3-Dimernsional Cell Culture” Angewandte Chemie 2009, in press. Namanja, H.; Emmert. D.; Pires, M. M.; Hrycyna, C.; Chmielewski, J. “Inhibition of Human P-glycoprotein Transport and Substrate Binding Using a Galantamine Dimer” Biochem. Biophys. Res. Comm. 2009, in press. Chmielewski, J. “Protease Dimer Formation Disrupted” Nature Chem. Bio. 2009, in press. Pires, M. M.; Emmert, D.; Chmielewski, J.; Hrycyna, C. A. “ABCB1 and ABCG2: Deciphering the Role of Human Efflux Proteins in Cellular and Tissue Permeability” ABC Transporters In Human Health and Disease, World Scientific Press, eds. Linton K.; Holland B., 2009, in press. Przybyla, D., Chmielewski, J. “Collagen Peptide Fiber Formation Triggered by Metal Ions” Breaking Away: Proc. of the 21st American Peptide Symp. 2009, in press. Ernenwein, D., Chmielewski, J. “Manipulating Solvent Exposed Residues for the Formation of a pH-Dependent Coiled Coil Peptide” Breaking Away: Proc. of the 21st American Peptide Symp. 2009, in press. Lee, J., Chmielewski, J. “Strand exchange of charged collagen-based peptides” Breaking Away: Proc. of the 21st American Peptide Symp. 2009, in press. Li, L.; Chen, H.; Geisler, I.; Chmielewski, J.; Cheng, J.-X. “Mitochondrial Targeting of Cationic Amphiphilic Polyproline Helices” 2009, submitted. Ernenwein, D., Ghosh, P., Rotello, V., Chmielewski, J. “Gold Nanoparticle Self-Assembly Promoted by a Non-Covalent, Charge-Complemented Coiled-Coil Peptide” 2009, manuscript in preparation. Lee, J.; Chmielewski, J. “Nucleation Studies of pH-Dependent Collagen Peptides” 2009, manuscript in preparation. Przybyla, D.; Chmielewski, J. “Metal-Triggered Self Assembling Collagen Peptide Disks” 2009, manuscript in preparation.